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Pharmascope Épisode 47: Votre attention s'il vous plaît, on parle de TDAH! (3 de 3)


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Vous êtes toujours parmi nous? La fin approche! Dans ce 47ème épisode du Pharmascope et dernier de la série sur le TDAH, Nicolas, Isabelle et leur invitée discutent entre autres des options de traitement pharmacologiques autres que les psychostimulants.

Les objectifs pour cet épisode sont :

  • Comprendre les risques et les bénéfices associés à la prise de l'atomoxetine et de la guanfacine
  • Évaluer la place de l'atomoxetine et la guanfacine dans l'algorithme de traitement du TDAH
  • Adapter le traitement pharmacologique du TDAH en fonction du patient

Ressources pertinentes en lien avec l'épisode

Lignes directrices canadiennes CADDRA – Canadian ADHD Ressource Alliance : Lignes directrices canadiennes pour le TDAH, quatrième édition, Toronto (Ontario); CADDRA 2018.

Lignes directrices américaines Wolraich ML et coll. Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. Subcommittee on children and adolescents with attention-deficit / hyperactive disorder. Pediatrics 2019. 144(4). pii:e20192528.

Revues du TDAH Thapar A, Cooper M. Attention deficit hyperactivity disorder. Lancet. 2016;387(10024):1240-50.

Auclair M, Elalami M. Traitement du TDAH chez l'enfant. Québec Pharmacie. Septembre 2018. 28p.

Revue systématique globale Stuhec M, Lukic P, Locatelli I. Efficacy, Acceptability, and Tolerability of Lisdexamfetamine, Mixed Amphetamine Salts, Methylphenidate, and Modafinil in the Treatment of Attention-Deficit Hyperactivity Disorder in Adults: A Systematic Review and Meta-analysis. Ann Pharmacother. 2019; 2:121-133.

Liens utiles pour ressources Canadian ADHD Ressource Alliance (CADDRA). 2020.

Centre for ADHD awareness, Canada (CADDAC). 2017.

Clinique FOCUS. 2020.

Annick Vincent. TDAH, informations, trucs et astuces. 2020.

Méta-analyse comparant l'atomoxétine aux psychostimulants en TDAH Liu Q, Zhang H, Fang Q, et coll. Comparative Efficacy and Safety of Methylphenidate and Atomoxetine for Attention-Deficit Hyperactivity Disorder in Children and Adolescents: Meta-analysis Based on Head-To-Head Trials. J Clin Exp Neuropsychol. 2017; 39(9): 854-65.

Évaluation de la guanfacine en TDAH par l'INESSS Institut national d'excellence en santé et services sociaux. INTUNIV XRMC – Trouble du déficit de l'attention avec ou sans hyperactivité. Février 2014.

Étude portant sur des doses de 1 à 7mg de guanfacine en TDAH chez l'adolescent Wilens TE, Robertson B, Sikirica V, et coll. A Randomized, Placebo-Controlled Trial of Guanfacine Extended Release in Adolescents With Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry 2015;54(11):916–925.

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