Proactive - Interviews for investors

Connected Minerals makes uranium breakthrough in Namibia

Race Oncology Ltd (ASX:RAC, OTC:RAONF) CEO Daniel Tillett joins Proactive’s Tylah Tully to discuss the FTO drug discovery program the company has concluded at Monash University’s Fragment Platform (MFP).

The program successfully identified 39 molecular candidates (‘hits’) that bind specifically to the m6A RNA demethylase protein, FTO.

These findings were validated using NMR spectroscopy and surface plasmon resonance.

The program leverages NMR fragment screening to discover drug-like molecules that can regulate protein activity outside the enzyme's active site, offering an alternative to traditional high-throughput screening.

The identified FTO-binding chemical scaffolds create opportunities for the development of patentable, first-in-class drugs targeting the m6A RNA epigenetic pathway.

RNA epigenetics dysregulation, involving proteins like FTO, is linked to various cancers and metabolic diseases. However, selective inhibition of FTO is challenging due to structural similarities with related proteins in the ALKBH family.

Race’s use of Monash’s curated chemical fragment library enabled the identification of unique FTO-binding structures.

Race plans a ‘hit-to-lead’ campaign to refine these fragments into lead drug candidates, focusing on improving potency, selectivity, toxicity profiles, and metabolic properties. The company is currently evaluating whether to proceed with this resource-intensive phase.

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Aclara Resources CFO Francois Motte joined Steve Darling from Proactive to announced the company has received a US$730,000 research, development, and innovation grant from the Chilean Economic Development Agency’s Innovation Management Division. Combined with Aclara’s own investment, the initiative will be funded with approximately $1 million to revolutionize rare earth element (REE) exploration using artificial intelligence (AI) models.

The project employs advanced machine learning to analyze complex datasets in real time, focusing on the identification of REE mineralization within ionic clay deposits. By integrating field data gathered by Aclara’s Exploration Team, the AI system combines data processing power with geological interpretation to evaluate extensive land areas efficiently.

This innovative approach is expected to optimize operational efficiency, reduce exploration costs, and minimize environmental impact, while also accelerating the identification of high-potential exploration targets.

“This grant validates our commitment to technological innovation and sustainable exploration practices,” Motte said. “By deploying cutting-edge AI tools, we aim to enhance our ability to uncover rare earth resources critical to the energy transition.”

Aclara Resources’ initiative represents a significant step forward in the exploration of ionic clay-hosted REE deposits, particularly in Chile, and positions the company as a leader in integrating technology and sustainability in mineral exploration.

#proactiveinvestors #aclararesourcesinc #tsx #ara #mining #rareearths#AclaraResources #CarinaProject #GoiásMoU #MiningInvestment #RenewableEnergy #EnvironmentalSustainability #JobCreation #InfrastructureDevelopment #BrazilMining #SustainableMining #ProactiveInvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

Hive Digital Technologies Chief Financial Officer Darcy Daubaras joined Steve Darling from Proactive to announced significant fleet enhancements with the purchase of 5,000 Avalon A15-194T ASIC miners, following an earlier acquisition of 6,500 Avalon miners this month. This brings the November total to 11,500 new miners, underscoring the company's commitment to cutting-edge operational upgrades.

The new equipment will replace older miners, improving efficiency from 22.3 J/TH to an industry-leading 19.5 J/TH and boosting Hive's operational capacity from 5.6 EH/s to 6.4 EH/s by the end of 2025. The upgrades align with Hive's ROI-driven capital allocation strategy and commitment to maintaining its leadership in mining efficiency.

Daubaras also shared progress on Hive’s 100 MW expansion in Paraguay, which will achieve 30 MW of mining capacity (approximately 2 EH/s) by early Q2 2025. This expansion will raise Hive’s total hashrate to 8.3 EH/s by the end of Q2 2025, complementing internal fleet upgrades slated for completion by March 2025.

"Our investments in advanced ASIC miners and Paraguay’s infrastructure reflect our focus on operational excellence and sustainable growth," Daubaras stated. "With these upgrades, Hive continues to set benchmarks for efficiency and capacity in the digital asset mining sector."

Hive remains at the forefront of digital asset mining, enhancing efficiency and scalability to meet growing global demand.

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#BitcoinMining #Cryptocurrency #GreenMining #ParaguayExpansion #BitcoinRewards #AvalonMiners #CryptoEfficiency #TechInnovation

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Reconnaissance Energy Africa CEO Brian Reinsborough joined Steve Darling from Proactive to share key updates on the company’s exploration activities in Namibia. ReconAfrica is currently drilling the Naingopo exploration well at a depth of approximately 4,000 meters. Upon completion, the company will execute a comprehensive logging and coring program, along with a vertical seismic profile, to assess potential oil or natural gas discoveries. Results will be analyzed and shared once the extensive logging and sample testing are complete.

Preparations for the Kambundu exploration well are also advancing, with road and well site construction nearly finalized. Drilling on the Kambundu site will commence after analyzing the Naingopo well results. Additionally, ReconAfrica is planning Namibia's first-ever onshore 3D seismic program, aiming to unlock further exploration opportunities in the region.

Significant cost-efficiency measures have also been implemented, reducing general and administrative expenses by $1 million compared to the same period last year. The company further strengthened its financial position through a partnership with BW Energy Limited, which acquired a 20% working interest in Petroleum Exploration Licence 073. This agreement includes a $22 million equity investment to fund a multi-well exploration program.

ReconAfrica’s strategic initiatives reinforce its commitment to efficient operations and expanded exploration in Namibia.

#proactiveinvestors #reconnaissanceenergyafricaltd #tsxv #reco #otcqx #recaf

#OilAndGasExploration #EnergyInvestments #BrianReinsborough #NamibiaDrilling #3DSeismicSurvey #OilIndustryUpdates #CorporateEfficiency #EnergyDevelopment

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Hyliion Holdings CEO Thomas Healy joined Steve Darling from Proactive announced the successful demonstration of the company’s KARNO generator, showcasing its groundbreaking fuel-agnostic capabilities during live tests. The KARNO generator seamlessly transitioned between natural gas, nitrogen-rich syngas, and various hydrogen-natural gas mixtures without requiring recalibration or shutdown. This innovative design offers robust adaptability to over 20 fuels, including natural gas, hydrogen, propane, diesel, ammonia, and methane, positioning the generator as a flexible and sustainable power solution.

Designed for ultra-low NOx and CO emissions and capable of achieving zero carbon emissions with specific fuels, the KARNO generator represents a significant leap in sustainable energy technology. Its ability to accommodate real-world fuel variability makes it an ideal solution for sectors like EV charging, data centers, waste gas utilization, and marine power.

Hyliion expects initial deliveries to early adopters by the end of the year. While not all compatible fuels will be commercially available at launch, the KARNO generator is positioned to future-proof energy systems, offering customers the flexibility to transition between traditional and alternative fuels.

Additionally, Hyliion secured a $17.2 million contract with the Office of Naval Research, adding to its ongoing R&D work on KARNO generator applications for the U.S. Navy. This includes the procurement of up to seven KARNO units. The company reaffirmed its 2025 revenue guidance in the low double-digit millions, driven by adoption across multiple sectors and ongoing innovation.

“The KARNO generator is a breakthrough in fuel flexibility and sustainable power,” Healy stated. “We’re excited to bring this revolutionary technology to market, enabling customers to navigate the energy transition seamlessly.”

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Silo Pharma CEO Eric Weisblum joined Steve Darling from Proactive to discuss the company’s positive findings from a preclinical study on its novel dual-target formulation designed to address major depressive disorder and severe stress-related conditions. Weisblum highlighted the promising potential of the treatment to deliver enhanced outcomes by combining two therapeutic approaches.

The study revealed that this formulation, which simultaneously targets two key pathways linked to mood and stress regulation, demonstrated superior effectiveness in reducing stress-induced behaviors compared to treatments focusing on a single pathway. Animal models showed notable improvements in behavioral outcomes, suggesting the approach could be particularly effective in managing severe psychiatric challenges.

Weisblum shared that the formulation is being explored as a potential intranasal preventative treatment for post-traumatic stress disorder (PTSD). The company is now preparing for an Investigational New Drug (IND) submission to progress to human clinical trials.

“This study validates our innovative dual-target approach,” Weisblum stated. “By addressing two critical mechanisms simultaneously, we aim to set a new benchmark in care for patients struggling with debilitating stress-related conditions.”

Silo Pharma’s advancements reflect its dedication to developing groundbreaking solutions for complex psychiatric disorders. The company is optimistic about transitioning its research into clinical development to meet the urgent need for improved mental health treatments.

#proactiveinvestors #silopharmainc #nasdaq #silo

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Silver47 Exploration Corp CEO Gary Thompson joined Steve Darling from Proactive to announce promising results from its 2024 drill program at the flagship Red Mountain Project in Alaska. CEO Gary Thompson joined Proactive to discuss findings from the first of six holes drilled this year, emphasizing the potential for high-grade infill drilling in the Dry Creek resource area.

A total of 1,039 metres of drilling was completed across the Dry Creek, West Tundra Flats, and Kiwi prospects. Notably, drilling at Dry Creek uncovered several massive sulphide horizons within a 24.5-metre semi-massive mineralized section, yielding the highest gold grade interval ever recorded at the project. The mineralization remains open, signaling potential for further resource expansion.

The Dry Creek Zone mineralization features multiple horizons of semi-massive to massive sulfides within the Totatlanika Schist, a geological formation known for hosting volcanogenic massive sulfide (VMS) deposits. These mineralized horizons, which include the Fosters and Discovery lenses, span a central 1,400 metres of the Dry Creek North Horizon and are rich in silver, zinc, lead, gold, and copper sulfides.

Drilling also revealed geological features such as growth faults near the Fosters lens, suggesting proximity to a VMS feeder zone—a potential source of significant mineralization. With true width intersections reaching up to 40 metres, the findings underscore the project's high-grade potential and its capacity for long-term development.

Silver47 continues to advance exploration at Red Mountain, focusing on defining and expanding its resource base while targeting deeper mineralized zones.

#proactiveinvestors #silver47explorstioncorp #tsxv #aga

#SilverAndGold #AlaskaExploration #RedMountain #PolymetallicMining #ResourceDevelopment #ProactiveInvestors #GaryThompson

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Nextech3D.ai CEO Evan Gappelberg joined Steve Darling from Proactive to unveil the rebranding of its spin-out company, Toggle.ai, to FOTOgpt.ai, signaling a shift towards AI-driven innovations in photography. Nextech3D.ai retains a 45% ownership stake, holding 13 million shares in the newly rebranded company.

FOTOgpt.ai is set to launch an AI-powered photography studio API plugin in December 2024, targeting developers and businesses seeking to integrate advanced photography features. This will be followed by the release of a standalone mobile application for iOS and Android in Q1 2025.

The platform utilizes cutting-edge AI technology to redefine photo capturing, editing, and optimization, catering to both professional photographers and casual users. Features include next-level automation for professionals and intuitive tools for seamless enhancements for everyday users.

"The launch of FOTOgpt.ai will bring transformative photography tools to individuals and businesses alike," said Gappelberg. "With its API integration and user-friendly mobile app, FOTOgpt.ai is poised to revolutionize the photography industry."

This innovation reinforces Nextech3D.ai’s commitment to leveraging AI technologies for creative and practical solutions, opening new possibilities in the photography sector.

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U.S. Gold Corp CEO George Bee speaks with Proactive's Stephen Gunnion about the company’s latest milestone. Bee confirmed that U.S. Gold Corp's Gold King Corp. subsidiary has received final permit approval from Air Quality Division of the Wyoming Department of Environmental Quality for the CK Gold Project. He described this as a major step forward for the shovel-ready project, emphasizing its unique position in a stable jurisdiction.

Bee highlighted the favorable market conditions, with gold prices exceeding $2,600 per ounce, significantly enhancing the project’s economics. "Since we last published numbers in 2021, gold and copper prices have increased, ensuring we preserve a healthy margin," Bee said.

The company is progressing with an updated pre-feasibility study (PFS), which integrates cutting-edge technologies like Glencore’s Jameson Cells and optimized tailings management plans. The PFS is expected to be followed by a final feasibility study in the first half of next year.

Bee expressed optimism about CK Gold becoming Wyoming's first producing copper and gold mine in decades, which he said would diversify the state’s resource portfolio. He emphasized the cooperative nature of Wyoming’s regulatory environment, calling it a great jurisdiction for resource development.

For more updates on U.S. Gold Corp and other industry insights, visit Proactive's YouTube channel. Don’t forget to like the video, subscribe, and enable notifications to stay informed.

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