Comedian Brett Erickson (@iBrettmypants) joins Matt and Andy on location at the Jim Jefferies Show offices to talk about meeting Slayer's guitarist Kerry King, Oliver Sacks' book An Anthropologist on Mars, Temple Grandin and her hug machine,  aphantasia, penis transplant updates, New York water updates, DNA findings leading to the Golden State Killer, caterpillar danger, Globetrotters facts, an instrument to help reveal faint exoplanets, the Retro Encabulator, The Freeze, and large spleens.

Comedian/actor/writer Emily Fleming (@FlemilyEming) joins Matt and Andy to discuss bad AI, gastro doctoring, constidar, Andy’s phone getting stolen mid-show, the smell of Uranus, New York water, penis transplants, David Reimer, ravens ruining science, why privacy on the internet isn't privacy and kids bouncing back from bouncing.

Comedian/neuroscientist Dr. Jono Zalay (@JonoZalay) joins Matt and Andy to discuss coke rats, accidental rat ejaculation, ibogaine for opiates, ketamine for depression, rodent cocktail, animal popularity, a daring baboon escape, pronouncing science words, endangered charismatic animals, chili head, the Scoville scale and Jono's licenses.

Comedian and podcaster David Smalley (@davidcsmalley) joins Matt and Andy to talk about bullying bullies, different names, Texan science, why meth is bad, paints for self-driving cars, herpes, 3D printing with space poop, what we should have printed, and women who lost their hair after eating bitter squash.

Comedian and Guy Fieri apologist Shane Torres (@shanetorres) makes his first appearance on the show, joining Andy and Matt to talk about horse herpes and rodeo adaptation, the #DickTracyChallenge, super gonorrhea, acupuncture studies, cocaine and Parkinson's, spray-on skin update and HVAC and Legionnaires' disease.

Comedian Ian Abramson (@ianabramson) joins Andy and Matt to talk about the death of Jim Jefferies, the Inland Empire, Roger Bannister, how fast the average person can run, Dick Tracy, a rocket man and the flat earth conspiracy conspiracy, Andy's connection to a waterslide tragedy, Grantland's article about said waterslide, magic skin spray, dirty rubber duckies, the forensic mystery behind Legionnaires' disease, essential oils for boy boobs, California’s silly Prop 65 cancer warning, Uber still sucking, Ian's Conan appearance and the #DickTracyChallenge.

Actor and TOFOP co-host Charlie Clausen (@CXClausen) joins Matt and Andy to discuss Aussie soaps, dental nightmares, Mask vs. The Mask, Eric Stoltz, Daylight Saving Time and koalas, smell-the-fart acting, political reasons for slow clocks, pizza innovation and The Noid, space twins and DNA, Dolph Lundgren gym run-ins and self-driving car risks.

Comedian/writer/producer/host of Adult Swim's Soft Focus Jena Friedman (@JenaFreidman) joins Matt and Andy for an on-location recording talking about Cannibal Cop, Jena's cold fusion-seeking grandfather, acupuncture and opioids, how the Sackler family are murderers, Hitler's art, new battery technology, Tesla's megabattery, Dinorwig, the political economy of Chicago’s improv scene and Jena’s thesis, the  ethnographic method, the Comedy Cellar podcast and rape statistics, female emotional labor and millions of penguins.

This episode is brought to you by Hello Fresh. For $30 off of your first week, visit hellofresh.com and use the code "probably30"

Comedian James Fritz (@fritzisdead) joins Andy and Matt to discuss Kentucky science, Oscars theories, magic mushrooms, neanderthal art, turkey history and Ben Franklin on birds, airplane air, soldier terminology, the early universe, scientists running for office and Matt's recent Star Talk appearance with Stephen Hawking, Janna Levin and Michio Kaku.

Writer and friend of the show Sarah Morgan (@sarahlmorgan) returns to talk with Matt and Andy about the prey defines the chase, vampire bats, memory wire, bismuth, robo-bees, playing HQ Trivia (and using the referral codes "andytwood" or "Mattbk"), Uber scams, plants and anesthesia, motherland vs. fatherland, curing Alzheimers in mice, pervy Koko the gorilla and reading too much into animal communication.