The National Institutes of Health recently launched their "All of Us" Initiative, with the goal of compiling detailed health profiles of 1 million Americans. Gathering so much sensitive information raises important ethical questions about consent, privacy, and inclusivity. This month on Ethics Talk, we discussed strategies for protecting participants and ensuring that diverse communities are represented. Our guests were Dr. Katie Johansen-Taber, an expert on precision health issues, and Ysabel Duron, a community representative on the All of Us Institutional Review Board.