The Carpenters were an American vocal and instrumental duo of Karen and Richard Carpenter. They produced a distinct soft musical style, combining Karen's contralto vocals with Richard's arranging and composition skills. During their 14-year career, the Carpenters recorded ten albums, along with numerous singles and several television specials.

The siblings were born in New Haven, Connecticut, and moved to Downey, California, in 1963. Richard took piano lessons as a child, progressing to California State University, Long Beach, while Karen learned the drums. They first performed together as a duo in 1965 and formed the jazz-oriented Richard Carpenter Trio followed by the middle-of-the-road group Spectrum. Signing as Carpenters to A&M Records in 1969, they achieved major success the following year with the hit singles " Close to You" and "We've Only Just Begun". Subsequently, the duo's brand of melodic pop produced a record-breaking run of hit recordings on the American Top 40 and Adult Contemporary charts, and they became leading sellers in the soft rock, easy listening and Adult contemporary music genres. The Carpenters had three No. 1 singles and five No. 2 singles on the Billboard Hot 100 and fifteen No. 1 hits on the Adult Contemporary chart, in addition to twelve top 10 singles. They have sold more than 90 million records worldwide, making them one of the best-selling music artists of all time. The duo toured continually during the 1970s, which put them under increased strain; Richard took a year off in 1979 after he had become addicted to Quaaludes, while Karen suffered from anorexia nervosa.

Their career together ended in 1983 following Karen's death from heart failure brought on by complications of anorexia. Extensive news coverage surrounding these circumstances increased public awareness of eating disorders. Though the Carpenters were criticized for their clean-cut and wholesome conservative image in the 1970s, their music has since been re-evaluated, attracting critical acclaim and continued commercial success.

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The Carpenters were an American vocal and instrumental duo of Karen and Richard Carpenter. They produced a distinct soft musical style, combining Karen's contralto vocals with Richard's arranging and composition skills. During their 14-year career, the Carpenters recorded ten albums, along with numerous singles and several television specials.

The siblings were born in New Haven, Connecticut, and moved to Downey, California, in 1963. Richard took piano lessons as a child, progressing to California State University, Long Beach, while Karen learned the drums. They first performed together as a duo in 1965 and formed the jazz-oriented Richard Carpenter Trio followed by the middle-of-the-road group Spectrum. Signing as Carpenters to A&M Records in 1969, they achieved major success the following year with the hit singles " Close to You" and "We've Only Just Begun". Subsequently, the duo's brand of melodic pop produced a record-breaking run of hit recordings on the American Top 40 and Adult Contemporary charts, and they became leading sellers in the soft rock, easy listening and Adult contemporary music genres. The Carpenters had three No. 1 singles and five No. 2 singles on the Billboard Hot 100 and fifteen No. 1 hits on the Adult Contemporary chart, in addition to twelve top 10 singles. They have sold more than 90 million records worldwide, making them one of the best-selling music artists of all time. The duo toured continually during the 1970s, which put them under increased strain; Richard took a year off in 1979 after he had become addicted to Quaaludes, while Karen suffered from anorexia nervosa.

Their career together ended in 1983 following Karen's death from heart failure brought on by complications of anorexia. Extensive news coverage surrounding these circumstances increased public awareness of eating disorders. Though the Carpenters were criticized for their clean-cut and wholesome conservative image in the 1970s, their music has since been re-evaluated, attracting critical acclaim and continued commercial success.

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The Carpenters were an American vocal and instrumental duo of Karen and Richard Carpenter. They produced a distinct soft musical style, combining Karen's contralto vocals with Richard's arranging and composition skills. During their 14-year career, the Carpenters recorded ten albums, along with numerous singles and several television specials.

The siblings were born in New Haven, Connecticut, and moved to Downey, California, in 1963. Richard took piano lessons as a child, progressing to California State University, Long Beach, while Karen learned the drums. They first performed together as a duo in 1965 and formed the jazz-oriented Richard Carpenter Trio followed by the middle-of-the-road group Spectrum. Signing as Carpenters to A&M Records in 1969, they achieved major success the following year with the hit singles " Close to You" and "We've Only Just Begun". Subsequently, the duo's brand of melodic pop produced a record-breaking run of hit recordings on the American Top 40 and Adult Contemporary charts, and they became leading sellers in the soft rock, easy listening and Adult contemporary music genres. The Carpenters had three No. 1 singles and five No. 2 singles on the Billboard Hot 100 and fifteen No. 1 hits on the Adult Contemporary chart, in addition to twelve top 10 singles. They have sold more than 90 million records worldwide, making them one of the best-selling music artists of all time. The duo toured continually during the 1970s, which put them under increased strain; Richard took a year off in 1979 after he had become addicted to Quaaludes, while Karen suffered from anorexia nervosa.

Their career together ended in 1983 following Karen's death from heart failure brought on by complications of anorexia. Extensive news coverage surrounding these circumstances increased public awareness of eating disorders. Though the Carpenters were criticized for their clean-cut and wholesome conservative image in the 1970s, their music has since been re-evaluated, attracting critical acclaim and continued commercial success.

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Richard was a quiet child who spent most of his time at home listening to Rachmaninoff, Tchaikovsky, Red Nichols and Spike Jones, and playing the piano. Karen was friendly and outgoing; she liked to play sports, including softball with the neighborhood kids, but still spent a lot of time listening to music. She enjoyed dancing and began ballet and tap classes aged four. Karen and Richard were close, and shared a common interest in music. In particular, they became fans of Les Paul and Mary Ford, whose music featured multiple overdubbed voices and instruments. Richard began piano lessons aged eight, but quickly grew frustrated with the formal direction of the lessons and quit after a year. He had begun to teach himself how to play by ear by 11, and resumed studying with a different teacher. He took a greater interest in playing this time, and would frequently practice at home. By age 14, he was interested in performing professionally, and started lessons at Yale School of Music.

By 1965, Karen had been practicing the drums for a year, and Richard was refining his piano techniques under Pooler's tuition. Late that year, Richard teamed up with Jacobs, who played tuba and stand-up bass. With Karen drumming, the three formed the jazz-oriented Richard Carpenter Trio.

Richard and Karen then teamed up with student musicians from Long Beach State to form the band Spectrum. The group sent demos to various record labels around Los Angeles, with little success. Part of the problem was the group's middle-of-the-road sound, which was different to the psychedelic rock popular in clubs. Spectrum performed regularly at the Whisky a Go Go nightclub in Los Angeles, including opening for Steppenwolf early in that group's career.

By 1968, Spectrum had disbanded, finding it difficult to get gigs as their music was not considered "danceable" Having enjoyed their multi-layer sound experiments at Osborn's studio, Richard and Karen decided to formally become a duo, calling themselves Carpenters.

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Percy Lavon Julian (April 11, 1899 – April 19, 1975) was an African American research chemist and a pioneer in the chemical synthesis of medicinal drugs from plants. He was the first to synthesize the natural product physostigmine, and a pioneer in the industrial large-scale chemical synthesis of the human hormones progesterone and testosterone from plant sterols such as stigmasterol and sitosterol. His work laid the foundation for the steroid drug industry's production of cortisone, other corticosteroids, and birth control pills.

He later started his own company to synthesize steroid intermediates from the wild Mexican yam. His work helped greatly reduce the cost of steroid intermediates to large multinational pharmaceutical companies, helping to significantly expand the use of several important drugs.

Julian received more than 130 chemical patents. He was one of the first African Americans to receive a doctorate in chemistry. He was the first African-American chemist inducted into the National Academy of Sciences, and the second African-American scientist inducted (behind David Blackwell) from any field.

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After two years, Glidden abandoned production of cortisone to concentrate on Substance S. Julian developed a multistep process for conversion of pregnenolone, available in abundance from soybean oil sterols, to cortexolone. In 1952, Glidden, which had been producing progesterone and other steroids from soybean oil, shut down its own production and began importing them from Mexico through an arrangement with Diosynth (a small Mexican company founded in 1947 by Russell Marker after leaving Syntex). Glidden's cost of production of cortexolone was relatively high, so Upjohn decided to use progesterone, available in large quantity at low cost from Syntex, to produce cortisone and hydrocortisone.

In 1953, Julian founded his own research firm, Julian Laboratories, Inc. He brought many of his best chemists, including African-Americans and women, from Glidden to his own company. Julian won a contract to provide Upjohn with $2 million worth of progesterone To compete against Syntex, he would have to use the same Mexican yam Mexican barbasco trade as his starting material. Julian used his own money and borrowed from friends to build a processing plant in Mexico, but he could not get a permit from the government to harvest the yams. Abraham Zlotnik, a former Jewish University of Vienna classmate whom Julian had helped escape from the Holocaust, led a search to find a new source of the yam in Guatemala for the company.

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Circa 1950, Julian moved his family to the Chicago suburb of Oak Park, becoming the first African-American family to reside there. Although some residents welcomed them into the community, there was also opposition. Before they even moved in, on Thanksgiving Day, 1950, their home was fire-bombed. Later, after they moved in, the house was attacked with dynamite on June 12, 1951. The attacks galvanized the community, and a community group was formed to support the Julians. Julian's son later recounted that during these times, he and his father often kept watch over the family's property by sitting in a tree with a shotgun

Julian's research at Glidden changed direction in 1940 when he began work on synthesizing progesterone, estrogen, and testosterone from the plant sterols stigmasterol and sitosterol, isolated from soybean oil by a foam technique he invented and patented. At that time clinicians were discovering many uses for the newly discovered hormones. However, only minute quantities could be extracted from hundreds of pounds of the spinal cords of animals.

On April 13, 1949, rheumatologist Philip Hench at the Mayo Clinic announced the dramatic effectiveness of cortisone in treating rheumatoid arthritis. The cortisone was produced by Merck at great expense using a complex 36-step synthesis developed by chemist Lewis Sarett, starting with deoxycholic acid from cattle bile acids. On September 30, 1949, Julian announced an improvement in the process of producing cortisone. This eliminated the need to use osmium tetroxide, which was a rare and expensive chemical. By 1950, Glidden could begin producing closely related compounds which might have partial cortisone activity. Julian also announced the synthesis, starting with the cheap and readily available pregnenolone (synthesized from the soybean oil sterol stigmasterol) of the steroid cortexolone (also known as Reichstein's Substance S), a molecule that differed from cortisone by a single missing oxygen atom; and possibly 17α-hydroxyprogesterone and pregnenetriolone, which he hoped might also be effective in treating rheumatoid arthritis but unfortunately they were not.

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Julian's research at Glidden changed direction in 1940 when he began work on synthesizing progesterone, estrogen, and testosterone from the plant sterols stigmasterol and sitosterol, isolated from soybean oil by a foam technique he invented and patented. At that time clinicians were discovering many uses for the newly discovered hormones. However, only minute quantities could be extracted from hundreds of pounds of the spinal cords of animals.

In 1940 Julian was able to produce 100 lb of mixed soy sterols daily, which had a value of $10,000 as sex hormones. Julian was soon ozonizing 100 pounds daily of mixed sterol dibromides. The soy stigmasterol was easily converted into commercial quantities of the female hormone progesterone, and the first pound of progesterone he made, valued at $63,500 was shipped to the buyer, Upjohn, in an armored car. Production of other sex hormones soon followed.

His work made possible the production of these hormones on a larger industrial scale, with the potential of reducing the cost of treating hormonal deficiencies. Julian and his co-workers obtained patents for Glidden on key processes for the preparation of progesterone and testosterone from soybean plant sterols. Product patents held by a former cartel of European pharmaceutical companies had prevented a significant reduction in wholesale and retail prices for clinical use of these hormones in the 1940s. He saved many lives with this discovery.

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At the lowest point in Julian's career, his former mentor, William Blanchard, threw him a much-needed lifeline. Blanchard offered Julian a position to teach organic chemistry at DePauw University in 1932. Julian then helped Josef Pikl, a fellow student at the University of Vienna, to come to the United States to work with him at DePauw. In 1935 Julian and Pikl completed the total synthesis of physostigmine and confirmed the structural formula assigned to it. Robert Robinson of Oxford University in the U.K. had been the first to publish a synthesis of physostigmine, but Julian noticed that the melting point of Robinson's end product was wrong, indicating that he had not created it. When Julian completed his synthesis, the melting point matched the correct one for natural physostigmine from the calabar bean.

Julian also extracted stigmasterol, which took its name from Physostigma venenosum, the west African calabar bean that he hoped could serve as raw material for synthesis of human steroidal hormones. At about this time, in 1934, Butenandt and Fernholz, in Germany had shown that stigmasterol, isolated from soybean oil, could be converted to progesterone by synthetic organic chemistry.

In 1936 Julian was denied a professorship at DePauw for racial reasons. DuPont had offered a job to fellow chemist Josef Pikl but declined to hire Julian, despite his superlative qualifications as an organic chemist, apologizing that they were "unaware he was a Negro". Julian next applied for a job at the Institute of Paper Chemistry (IPC) in Appleton, Wisconsin. However, Appleton was a sundown town, forbidding African Americans from staying overnight, stating directly: "No Negro should be bed or boarded overnight in Appleton."

Meanwhile, Julian had written to the Glidden Company, a supplier of soybean oil products, to request a five-gallon sample of the oil to use as his starting point for the synthesis of human steroidal sex hormones (in part because his wife was suffering from infertility). After receiving the request, W. J. O'Brien, a vice-president at Glidden, made a telephone call to Julian, offering him the position of director of research at Glidden's Soya Products Division in Chicago. He was very likely offered the job by O'Brien because he was fluent in German, and Glidden had just purchased a modern continuous countercurrent solvent extraction plant from Germany for the extraction of vegetable oil from soybeans for paints and other uses

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After returning from Vienna, Julian taught for one year at Howard University. At Howard, in part due to his position as a department head, Julian became caught up in university politics, setting off an embarrassing chain of events. At university president Mordecai Wyatt Johnson's request, he goaded white Professor of chemistry, Jacob Shohan into resigning.In late May 1932, Shohan retaliated by releasing to the local African-American newspaper the letters Julian had written to him from Vienna. The letters described "a variety of subjects from wine, pretty Viennese women, music and dances, to chemical experiments and plans for the new chemical building." In the letters, he spoke with familiarity, and with some derision, of specific members of the Howard University faculty, terming one well-known Dean, an "ass".

Around this same time, Julian also became entangled in an interpersonal conflict with his laboratory assistant, Robert Thompson. Julian had recommended Thompson for dismissal in March 1932. Thompson sued Julian for "alienating the affections of his wife", Anna Roselle Thompson, stating he had seen them together in a sexual tryst. Julian counter-sued him for libel. When Thompson was fired, he too gave the paper intimate and personal letters which Julian had written to him from Vienna. Dr. Julian's letters revealed "how he fooled the [Howard] president into accepting his plans for the chemistry building" and "how he bluffed his good friend into appointing" a professor of Julian's liking. Through the summer of 1932, the Baltimore Afro-American published all of Julian's letters. Eventually, the scandal and accompanying pressure forced Julian to resign. He lost his position and everything he had worked for.

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