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Today’s dog breeders are getting a boost from the burgeoning field of genetic testing. Doberman Diversity Project co-founder Sophie Liu talks about her work using advanced tools to improve genetic health issues in Doberman Pinschers.
Liu was a vet student researching her next dog when she became aware of the multitude of health challenges facing Dobermans.
According to the DDP website:
OUR MISSION is to reduce the incidence of heritable diseases in the Doberman by studying and addressing the depression in the overall genetic diversity of the Doberman breed and studying and researching widespread disease-associated mutations, through comprehensive genetic testing and analysis, development and sharing of evidence-based breeding findings, development of online breeder decision-making tools, and long-term tracking of results to measure the effectiveness of varied approaches to breeding -- in terms of genetic health and longevity.Combatting DCMLiu said that a major focus of their research is geared toward reducing the incidence of Dilated Cardiomyopathy in the breed, which currently is plagued by the devastating disease, with nearly half of the breed being affected.
A great deal of DDP’s research and studies are directed at developing a tool which establishes a genetic value for the risk of passing on DCM. Building on the work done by Guide Dogs for the Blind, DDP hopes to enable breeders to determine an “estimated breeding value” for DCM on a pedigree and genetic basis.
“This is a super powerful tool,” Liu said. “This is how guide dogs have systematically improved their breeding program.”
The two genes identified to date that are associated with DCM in Dobermans are autosomal dominant, Liu said. Because the disease shows up late in a dog’s life, it can be hard to stay ahead of, she noted.
Genetic testing offered through Embark at cost enables DDP to track genetic data. Study participants also update all clinical health data for the research project.
Need more dogs testedLiu said that in just about two years DDP has tested more than 2,500 dogs, but they need many more.
“We need more dogs tested. Affected and unaffected dogs. We need raw data and clinical updates and medical records,” Liu said. The guide dog programs’ success relies on having the advantage of huge breeding colonies that are all tested in house, she added.
DDP’s relationship with Embark enables breeders to find the right balance between the inbreeding percentages needed to fix type and maintain health. Embark’s breeder tool enables people to make that decision for themselves, Liu noted, “just like Tinder for your Doberman.”
“We’re finding out that the genetic bottlenecks are worse than we thought,” Liu noted. “Over 99% of Dobermans share a single paternal haplotype, in other words, one stud dog is behind nearly every Doberman tested.”The research is also turning up valuable information about the heritability of various traits – in other words, how much variation of the trait is genetic. For example, studies indicate 40 percent of fear behavior is genetic. For more on the topic of how genetics impact fear behavior, listen to Pure Dog Talk Episode 221.
“People go to breeders for consistency,” Liu said. “The better we get at it, the better it is for everyone.”Pure Dog Talk is sponsored by:
Emmy award-winning investigative journalist Elena Mannes shares her story of the journey on which she embarked with her first dog, a Standard Poodle.
Soul Dog – A Journey into the Spiritual Life of Animals chronicles Mannes’ determined quest to harness her inner dog whisperer by learning to decipher the unspoken language present in every animal-human relationship.
“I brought Brio home… and it wasn’t really going according to plan. I really just thought I would get trainers and support and it wouldn’t really change my life to have a puppy,” Mannes said with a rueful chuckle.
“One time, I had him in Central Park. I had started to have him off leash… he would take off and not come back when I called. I was walking backward, screaming at him to come. All of the sudden, there was no ground under me… I stepped off the edge of the boat pond and fell in…. Brio eventually came back and just stared at me.”
Skeptic to believer“I felt sort of desperate. I didn’t talk dog. I heard about animal communicators, but I was a real skeptic. I’m a TV journalist, I don’t like woowoo things.
“(Brio) changed me in so many ways as the years went by and the connection became so deep and really life changing for me,” Mannes said.
Mannes also addressed her decision to choose a purebred dog.
“I respect people who rescue, but in my situation at the time I really didn’t know enough. I had a sense of Standard Poodles that they were so smart. I was scared to death (of adding a dog to my life),” Mannes said, adding that the predictability of a purebred dog helped provide some comfort in this decision.***
Elena Mannes is a multi-award-winning independent documentary director/writer/producer as well as an author. Her first book, The Power of Music: Pioneering Discoveries in the New Science of Song, is published by Walker Books/Bloomsbury USA (May 31, 2011).
Her work has appeared on both public and commercial television. Her honors include six national Emmys, a George Foster Peabody Award, two Directors Guild of America Awards, and nine Cine Golden Eagles.
Mannes developed and created a primetime PBS special, The Music Instinct: Science and Song,a co-production with WNET/Thirteen.
Mannes productions include the feature documentary film Amazing Grace with Bill Moyers (PBS) which won the Directors Guild Award as well as an Emmy for directing. For ABC, Mannes has produced a special with Diane Sawyer The Amazing Animal Mind, exploring the intelligence and emotions of dogs and other animals, as well as other ABC hours including Ground Zero with Peter Jennings which won an Emmy for best Historical Program.
Mannes has also produced and directed documentaries for CBS REPORTS and segments for 60 MINUTES and PRIME TIME LIVE (ABC).She worked with George Lucas to develop a television project incorporating documentary and dramatic sequences.
Mannes is a member of one of the first families of American music. Her grandparents founded the Mannes College of Music in New York City; and her great uncle, Walter Damrosch conducted the Metropolitan Opera and instigated the building of Carnegie Hall.
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