Pushing The Limits

Your blood tests come back "normal", but you don't feel normal.

You wake at 3am with your mind racing, your hands and feet are always cold, the fog won't lift and your energy has gone. In this solo episode I unpack methylation, one of the most important systems in your body and one almost nobody is testing for. In this episode: - What methylation actually does, and why SAMe and homocysteine matter so much -

The gene team behind it: MTHFR, MTR, MTRR, TCN2, FUT2, DHFR, COMT, PEMT, HNMT, CYP1B1, NOS3, CBS and BHMT - Who is most at risk, including medications and lifestyle factors that quietly drain B12 and folate - What high homocysteine means for your bones, heart and blood vessels, brain, mood, hormones and histamine -

Why I don't use folic acid, and what I use instead: methylfolate, folinic acid and the right forms of B12 - The methyl trap, and why folate and B12 always need fixing together -

Why taking SAMe on its own isn't the fix - The supporting cast: riboflavin, B6, choline, TMG and omega-3 -

How to test properly: homocysteine, active B12, folate, MMA and MCV If you're pregnant or planning a pregnancy, don't change your folate on your own.

Get properly assessed first.

Want to know what your own methylation genes are doing?

My DNA Blueprint Package covers methylation, COMT, PEMT, your oestrogen genes and much more, with a personalised plan and a one-on-one consult with me. https://lisatamati.com/dna

Watch the full video on YouTube: search "Lisa Tamati methylation" More episodes: https://www.lisatamati.com/ptl-podcast/

Shop: https://shop.lisatamati.com

This episode is for education only and isn't individual medical advice.

heir average age was 22 and 77% had artery disease. What are your genes doing to your heart?

That's what doctors found in 1953 when they examined the hearts of young US soldiers killed in the Korean War. Heart disease doesn't start at 60. It starts decades earlier, quietly.

In this episode I go gene by gene through the heart, artery and blood pressure genes on a DNA test: APOE, LPA, PON1, F5 (factor V Leiden), ACE, FADS1 and FADS2, 9p21, ABCG2 and NOS1. For each one: what the research actually shows, what your result can and can't tell you, and the practical steps that follow. I also cover the blood pressure toolkit, omega-3s and plasmalogens (the work of Dr Dayan Goodenowe), inflammation and immune ageing (Dr Elizabeth Yurth), and why women's heart risk changes at menopause.

Find out what your own genes say with my DNA Blueprint Package: https://lisatamati.com/dna Available in New Zealand, Australia and the USA.

Chapters 0:00 Heart disease at 22 0:43 Heart disease starts decades early 5:57 What a gene test can and can't tell you about your heart 9:20 APOE: the cholesterol transporter 12:24 LPA: the cholesterol particle you can't diet away 17:04 PON1: your HDL's bodyguard 19:18 F5: your clotting gene 22:19 ACE: blood pressure and saturated fat 25:53 Your blood pressure toolkit 28:37 FADS1 and FADS2: making your own omega-3s 35:43 9p21: the heart disease hotspot 38:47 ABCG2: uric acid 41:54 NOS1: nitric oxide 44:07 Inflammation: the fire in the artery wall 48:28 Women's hearts 50:09 Putting it all together 52:54 The long game 54:00 Your next step

Key research mentioned Enos et al., JAMA, 1953 (Korean War autopsies) McGill et al., PDAY, American Journal of Clinical Nutrition, 2000 Fernández-Friera et al., PESA study, Circulation, 2015 Cohen, Hobbs et al., PCSK9, New England Journal of Medicine, 2006 Yusuf et al., INTERHEART, The Lancet, 2004 Khera et al., genetic risk and healthy lifestyle, New England Journal of Medicine, 2016 Bennet et al., APOE and coronary risk, JAMA, 2007 Kamstrup et al., Lp(a), JAMA, 2009; Clarke et al., New England Journal of Medicine, 2009 Bhattacharyya et al., PON1, JAMA, 2008 Bertina et al., factor V Leiden, Nature, 1994; ESTHER study, Circulation, 2007 Schüler et al., ACE rs4343 and saturated fat, Journal of the American Heart Association, 2017 Neal et al., Salt Substitute and Stroke Study, New England Journal of Medicine, 2021 Edwards et al., exercise and blood pressure, British Journal of Sports Medicine, 2023 Lemaitre et al., FADS and omega-3s (CHARGE), PLoS Genetics, 2011 Helgadottir et al. and McPherson et al., 9p21, Science, 2007; Do et al., PLoS Medicine, 2011 Woodward et al., ABCG2 and uric acid, PNAS, 2009 Kapil et al., dietary nitrate and blood pressure, Hypertension, 2015 Ridker et al., CANTOS, New England Journal of Medicine, 2017

Disclosure: I'm a certified Prodrome practitioner and stock Dr Goodenowe's products in my store. I'm also co-founder of Aevum Labs, which makes Re:juvenate Pro (scientific advisor Dr Elizabeth Yurth).

More from me Watch the full video on YouTube: https://www.youtube.com/watch?v=BrlVQhShH24 Shop: https://shop.lisatamati.com Instagram: https://www.instagram.com/lisatamati/

Educational content only. Genetics shows tendencies and priorities, not diagnoses.

Why can one person drink a flat white at 3pm and sleep soundly, while another lies awake until midnight? Why does one glass of wine turn some people bright red? A lot of it comes down to your genes.

In this solo episode, I break down the caffeine and alcohol genes I look at in my clients' myDNA reports, what your results can and can't tell you, and the simple changes that follow.

In this episode: - How CYP1A2 shapes how long caffeine hangs around, and why your cut-off time matters - What the research shows about caffeine, genetics and athletic performance - ADORA2A, and why some people feel caffeine far more strongly than others - The ALDH2 variant behind the alcohol flush, and why it matters for more than a red face - The ripple effects: vitamin B1, REM sleep, APOE, and the unfiltered coffee and cholesterol link - Why genetics loads the gun, and environment pulls the trigger

Find out what your genes say with my DNA Blueprint Package, available in New Zealand, Australia and the USA: genetics, DNA test, nutrigenomics, myDNA, caffeine, coffee, alcohol, alcohol flush, red face after drinking, ALDH2, CYP1A2, ADORA2A, APOE, caffeine metabolism, sleep, REM sleep, thiamine, vitamin B1, cholesterol, longevity, personalised health, functional medicine, Lisa Tamati, Pushing the Limits

More on thiamine: my full interview with Elliot Overton https://www.youtube.com/watch?v=8qwb_XmDqqk

Chapters: 0:00 Same coffee, different genes 0:18 Why blanket health advice fails 1:00 Your caffeine gene: CYP1A2 2:48 Caffeine, sleep and the cut-off 3:27 Caffeine and athletic performance 4:34 ADORA2A: how strongly you feel caffeine 5:35 Alcohol and the ALDH2 gene 7:45 Ripple effects: B1, sleep, APOE and coffee 10:25 Genes load the gun 11:14 Your next step

Educational content only. Genetics shows tendencies and priorities, not diagnoses.

I ran 70,000km across the world's toughest deserts to lose weight, and I got heavier, more inflamed and sicker every year. I assumed the problem was discipline. It took one genetic test to show me it never was.

In this solo episode I make the case that your DNA is the single most valuable test you will ever do. Not because it tells you the most, but because it is the only test whose result is still true in fifty years. Your bloods reflect the last few weeks. Your microbiome shifts with every trip and every course of antibiotics. Your hormones move across the month and the decade. Your DNA does not move at all.

I go through all eight areas a comprehensive genetic panel covers, what you actually learn from each one, and why a variant is a tendency rather than a verdict.

IN THIS EPISODE

My own results, and the cascade that explains twenty-five years of getting it wrong Why genetics is different from every other test you will ever do Genetics loads the gun, environment pulls the trigger: what that actually means in practice The single-gene trap, and why the MTHFR obsession has it upside down Digestion, energy, hormones, stress and cognition, inflammation, athletic performance, DNA repair and detoxification, one at a time The difference between nutritional dosing and nutrigenomic dosing, and why more vitamin D was not working for me Why genetics alone is not enough, and what has to sit alongside it Why it is almost never discipline

THE DNA BLUEPRINT PACKAGE

Practitioner-only genetic testing, ninety-two genes and a hundred and thirteen variants across a report of roughly a hundred and twenty-one pages, read by me alongside a full Cell Blueprint assessment and turned into a complete personal health programme in a ninety-minute one-on-one.

Available throughout New Zealand. Australia coming soon. https://www.lisatamati.com/dna/

GO DEEPER

Dr Sam Shay on methylation, inflammation and exercise-induced obesity: https://www.lisatamati.com/podcast--dr-sam-shay_1/

Dr Mansoor Mohammed on how your variants change what you eat and how you train: https://www.lisatamati.com/podcast-mansoor-mohammed/

Read the long-form article: https://www.lisatamati.com/blog/

ALSO FROM LISA

Re:juvenate Pro, the foundational immune ageing formula from Aevum Labs: https://shop.lisatamati.com/pages/rejuvenate

Re:NRG, our next-generation NAD support, is coming. Join the waitlist for first access: https://shop.lisatamati.com/pages/nad-next-gen-waitlist

Weekly longevity insights, free: https://www.lisatamati.com/lisa

Questions or feedback: [email protected]

Pushing the Limits is hosted by Lisa Tamati, genetics practitioner, co-founder and Chief Science Officer of Aevum Labs, and former professional ultra-endurance athlete. Author of three books and one audiobook.

Your Immune Age Is Lying To You. Here's How To Read Your Blood And Fix It.

How old is your immune system, really?

It's probably not the same age as you are — and that gap may be the single biggest hidden driver of how well you age, how fast you recover, and how long you stay healthy. In this episode I break down what actually happens to your immune system as the years tick over — immunosenescence (the immune system getting weaker) and inflammaging (the silent, smouldering inflammation that never switches off) — and why almost every disease of ageing sits somewhere on that spectrum.

Then I get practical. I'll show you how to measure your immune age from a standard blood test you can get anywhere in the world, using seven scientifically validated ratios (NLR, PLR, MLR, LMR, SII, PIV and ELR) synthesised into a single Immune Resilience Index. We cover the cutting-edge science from Dr David Furman's 1000 Immunomes Project and the iAge inflammatory clock, the TRIIM and TRIIM-X thymus-regeneration trials, the gut-immune connection (70% of your immune cells live in your gut), the cytokines of ageing (IL-6, TNF-alpha, IL-1 beta, NF-kB and IL-10), and how our Re:juvenate Pro formulation was built to target exactly these pathways. If you want to stop guessing and start tracking the system that runs your healthspan, this one's for you

RELATED EPISODES — WATCH THESE NEXT

Dr David Furman | The 1000 Immunomes Project and the inflammatory clock of aging: https://www.youtube.com/watch?v=HFOSqEY7CNY

Dr Rod Claycomb | Colostrum, immune proteins and immune resilience: https://www.youtube.com/watch?v=VyOfcx9gvbE

Aevum Labs panel | Peter Lehrke, medical herbalist Mike Eyres and Dr Rod Claycomb: https://www.youtube.com/watch?v=EstwHB3p3nI

Dr Elizabeth Yurth | Immune aging and how to slow it: https://www.youtube.com/watch?v=h_-_rFXcBIA

THE SCIENCE + RE:JUVENATE PRO Re:juvenate Pro at Aevum Labs: https://aevumlabs.co.nz/products/re-juvenate Aevum Labs: https://www.aevumlabs.co.nz

🌐 Website: https://www.lisatamati.com

🛒 Supplements: https://shop.lisatamati.com

🎙️ Podcast: https://www.lisatamati.com/podcast

📧 Contact: [email protected]

The link between micronutrients and mental health is one of the most overlooked stories in modern medicine, and Professor Julia Rucklidge has spent more than two decades proving it matters. In this episode of Pushing the Limits, she shares the research on micronutrients and mental health that has challenged psychiatry's drug-first model, showing that broad-spectrum vitamins and minerals can treat ADHD, depression and anxiety, often as effectively as medication and without the side effects. If you have ever wondered how deeply micronutrients and mental health are connected, this conversation will change how you think about your brain, your mood and the food you eat every day.

Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. She is co-author, with Bonnie Kaplan, of The Better Brain, and her work has been published in leading psychiatry journals and viewed by millions through her TEDx talk. She came into this field as a sceptic, trained to believe that nutrition was irrelevant to the brain, and changed her mind only when the evidence became impossible to ignore.

In this conversation, Julia explains what her clinical trials actually found, and why 60 to 80 percent of people respond to a broad-spectrum approach once you move past the noise of a blinded study. We talk about why feeding the whole system beats chasing a single nutrient, what the biomarkers reveal about inflammation, methylation and the microbiome, and why the RDAs were never designed to support an optimally functioning brain. She makes the case that the recommended daily allowances we rely on were built to prevent deficiency diseases, not to help the brain thrive, and that this gap matters enormously for anyone struggling with their mental health.

We also explore the bigger forces at play: depleted soils and what modern agriculture has done to the nutrient density of our food, the rise of ultra-processed food and why Julia calls it the cigarette of the twenty-first century, and the antidepressant withdrawal that so many people are never warned about. She shares her frustration with New Zealand's outdated supplement regulations, where a product can be effectively banned for containing a fraction too much of a nutrient, and a distributor can be threatened with serious penalties for selling something that genuinely works.

Most of all, this is a hopeful conversation. It is about taking back control of your health through the food on your plate, understanding the real connection between what you eat and how you feel, and recognising that small, consistent changes can have a profound effect on the brain. Whether you are a parent navigating a child's behaviour, someone managing your own mental health, or simply curious about the science of nutrition and the brain, this episode will give you a new lens on what is possible.

If you have ever been told that nutrition is irrelevant to your brain, this episode is for you.

Resources and mentions: The Better Brain by Bonnie Kaplan and Julia Rucklidge What Your Food Ate by David Montgomery and Anne Biklé Te Puna Toiora, Mental Health and Nutrition Research Lab, University of Canterbury

Biography:

09:26   Claude responded: Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research L… div]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 standard-markdown">

Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. One of the world's leading researchers in nutritional psychiatry, she has spent more than two decades running placebo-controlled trials showing that broad-spectrum micronutrients can treat ADHD, depression, anxiety and stress, often as effectively as medication and without the side effects. She is co-author, with Bonnie Kaplan, of The Better Brain, and her TEDx talk on nutrition and mental health has been viewed millions of times. Based in Christchurch, New Zealand, she is on a mission to put nutrition where she argues it belongs: as a serious, evidence-based part of how we treat and prevent mental illness.

What if there was an exogenous ketone that didn't go through the liver, didn't cause the GI distress of other ketones, and delivered bioidentical BHB directly to your cells?

In this episode, Lisa sits down with Mike Chesne, founder of Tecton and retired US Army Special Forces combat medic, who spent 25 years in special operations before developing R3HBG — a patented ketone molecule that's categorically different from everything else on the market.

Mike's journey from battlefield medicine to biotech is extraordinary. After suffering multiple traumatic brain injuries from IED blasts during nearly three years of combat, he went through brain injury rehabilitation and discovered the neuroprotective potential of ketones. He asked one question that changed everything: "If I had been in ketosis when I got blown up, how much better would my outcome have been?"

That question led him to Oxford University, to Dr Kieran Clarke's lab, and eventually to designing his own molecule — drawing it on a napkin and spending over a decade turning it into a manufactured, FDA-reviewed product.

In this deep-dive episode we cover:

• Mike's military career and the brain injuries that changed his path
• The DARPA project that spent $10 million searching for a supplement to boost performance and cognition by 30%
• Why the brain in Alzheimer's and TBI can't access glucose but can still take up ketones
• R3HBG explained: how lipase (not alcohol dehydrogenase) breaks it down, and why that matters
• The differences between BHB salts, R-1,3-butanediol, the original ketone ester, and R3HBG
• The NLRP3 inflammasome and how BHB blocks the inflammatory cascade driving neurodegeneration
• HDAC inhibition and how BHB switches on your body's own antioxidant and longevity genes
• NDI #1354 and what FDA New Dietary Ingredient acceptance means
• The GLP-1 agonist connection for weight management and metabolic health
• Therapeutic dosing for cognition, endurance, and recovery
• Mike's vision to license R3HBG to every ketone company willing to use it
• Lisa's experience using ketones with her mother's brain injury and cancer recovery

This is the most comprehensive ketone science episode we've ever produced.

TECTON KETONES: Use this link for a discount https://tectonketones.com/discount/TAMATI

While you're optimising your brain and metabolic health, give your body foundational support with Re:juvenate Pro, my advanced cellular health and longevity formula (https://shop.lisatamati.com/pages/rejuvenate), and explore my full curated range of anti-aging and longevity supplements at shop.lisatamati.com.

CONNECT WITH LISA Website: lisatamati.com Shop: shop.lisatamati.com

Newsletter: www.lisatamati.com/lisa

Podcast: https://www.lisatamati.com/ptl-podcast/

Books: https://shop.lisatamati.com/collections/books

Pushing the Limits is brought to you by Lisa Tamati and the team at lisatamati.com.

What if the reason you're not getting better isn't about what you're putting in — but what you can't get out?

In this episode I sit down with Tash Simons from INUSpheresis Perth — the first clinic in Australia and the Southern Hemisphere to offer this advanced blood filtration therapy. We go deep into how double filtration plasmapheresis works, the two specialised filters (TKM58 and INUS 30), and the science behind removing autoantibodies, inflammatory cytokines, heavy metals, microplastics, PCBs, and oxidised LDL directly from your blood — without involving your kidneys or liver.

We cover the clinical research across long COVID, ME/CFS, autoimmune conditions, Lyme disease, Alzheimer's, and cardiovascular risk including Lp(a) — one of the hardest lipid markers to shift. Tash shares the personal story of how a family member's chronic fatigue led her and Dr Robbie Simons to discover this therapy in Vienna, and the journey to bring it to Perth — from TGA registration and insurance approvals to Swiss certification and over 100 treatments completed.

If you're dealing with a chronic condition that won't budge, carrying a toxic load, or thinking about longevity from a subtractive medicine perspective — this one's for you.

Book a consult or submit a new patient form at inuspheresisperth.com.au

Check out my supplement store at shop.lisatamati.com Rejuvenate Pro at shop.lisatamati.com/pages/rejuvenate My books at shop.lisatamati.com/collections/books Sign up for my newsletter at www.lisatamati.com/lisa Listen to more episodes at www.lisatamati.com/ptl-podcast/

div]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 standard-markdown">

This episode is also brought to you by Rejuvenate Pro from Aevum Labs. If INUSpheresis is about taking the bad stuff out, Rejuvenate Pro is about protecting what stays behind. Featuring kawakawa, carnosic acid, Immunel colostrum extract and IDP (Immune Defense Protein), it targets the chronic systemic inflammation that silently drives aging. It's the first supplement in every protocol I build for my clients — and it should be in yours. Shop now at shop.lisatamati.com/pages/rejuvenate

━━━━━━━━━━━━━━━━━━━

🌐 Website: https://www.lisatamati.com

🛒 Supplements: https://shop.lisatamati.com

📧 Contact: [email protected]

━━━━━━━━━━━━━━━━━━━━

Could a simple mineral deficiency be driving mitochondrial dysfunction in autism? In this episode I sit down with Melissa Atchley from MitoSynergy to hear her personal story of using BioCopper1 with her son on the autism spectrum — and the changes she saw that no one expected.

I break down the science behind it: Dr Richard Frye's research showing Complex IV dysfunction in children with ASD, the brand new April 2026 Science Advances paper linking copper deficiency directly to ASD-like behaviours through mitochondrial damage and impaired myelination, and why the type of copper matters — Cu1+ vs Cu2+ — more than most people realise.

We also cover MitoSynergy's new MitoActivator MAX (4x the strength of the standard formula), the hair greying reversal angle, athletic performance benefits, and practical dosing guidance. If you or someone you love is navigating autism, fatigue, grey hair, or just wants to understand why copper might be the most overlooked mineral in health — this one is worth your time.

Get yours in my shop: https://shop.lisatamati.com/products/mitoactivator-max-max-strength-biocopper1-supplement-60-capsmitosynergy-mitoactivator-max?_pos=2&_sid=5c471c21c&_ss=r

Or use code LisaTamati at Mitosynergy.com for your discount

These two doctors are building a clinic where the most advanced longevity therapies have no limits. Dr. Alexander Grinberg (Infinity Epigenetics, San Francisco) and Dr. Dave Jenkins (Bredesen-trained, 40+ years clinical experience) are combining peptide therapy, regenerative medicine, and personalised protocols at a level most people don't know exists. From Klotho protein restoring cognitive function in head injury patients to mitochondrial peptides that can rescue dying cells — this conversation covers the cutting edge of what's actually possible right now.

About the Guests

Dr. Alexander Grinberg MD is a physician, immunologist, and peptide therapy specialist practicing in San Francisco. He holds a fellowship from the Moscow Immunology Institute and consults internationally on advanced customised longevity protocols. He runs Infinity Epigenetics and teaches physicians in high-end integration of peptides, regenerative medicine, and genetic therapies.

Dr. Dave Jenkins is a New Zealand-trained physician with 40+ years of clinical experience specialising in metabolic and neurological health. He is Bredesen Protocol (ReCODE) trained and runs a longevity clinic in Bali. He co-developed a Type 2 Diabetes reversal program now being published and reviewed by NZ's top diabetic specialists.

In this episode

• Why Klotho protein may be one of the most powerful longevity interventions available — and the different delivery forms (protein injection, peptide fragments, gene therapy)
• Dr. Dave's clinical Klotho results: a doctor with chronic head injury returning to practice, and his own memory score jumping from the 66th to the 97th percentile in six weeks
• How mitochondrial peptides (MOTS-c, SS-31, Humanin) work and why dosing wrong can be dangerous — especially in autoimmune and cancer history cases
• The case for micro-dosing peptides and why skin testing should come first
• Personalised medicine taken to its extreme: harvesting a patient's own cells, expanding them in culture, and running accelerated longevity and cancer resilience tests before any intervention
• Why peptide purity and sourcing is a serious safety concern — and what the clinic will do differently
• The vision for a Pacific Island longevity clinic offering therapies unavailable in the US, EU, NZ, or Australia — with a social impact mission to address metabolic disease in local populations
• Off-label repurposed drugs for cancer (metformin, ivermectin, doxycycline, mebendazole) and why the regulatory environment matters
• How custom peptides designed from a patient's own genome could replace pharmaceuticals entirely

Resources mentioned

• Infinity Epigenetics — infinityepigenetics.com
• Dr. Dave Jenkins —
• 🌐 https://youngerbyscience.com/ 🌐 https://theendofalzheimers.com