Audio interview with Dr. David Hogan, geriatric medicine specialist at the University of Calgary. Quinine sulfate is widely used off label to treat nocturnal leg cramps in Canada. Although modestly effective for this indication, the drug has many potential moderate and severe adverse effects. Full article: http://www.cmaj.ca/content/early/2015/01/26/cmaj.150044. First published January 26, 2015, doi: 10.1503/cmaj.150044