Matthew Stafford and the Rams' high-powered offense overpowered a 49ers defense reeling from injuries on Sunday, handing San Francisco its first divisional loss with a 42-26 defeat. The 49ers remain locked in the NFC West's third-place spot, fighting for health and positioning as the playoff picture starts to crystallize in the season's second half. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan break down San Francisco's performance against the Rams in Week 10, from an inexperienced defense decimated by injuries to an offense expected to protect such deficiencies despite its own missing pieces. Matt and Jennifer help make sense of how San Francisco can contend moving forward in a highly competitive divisional and conference environment.

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(1:00) Matt Stafford and the Rams' offense seemed unstoppable
(6:00) Adjustment period continues for in-flux 49ers
(12:00) 49ers' inconsistencies a key sign of young team
(27:00) Will Brock Purdy return to the starting lineup in Week 11?
(37:00) What was the 49ers' mindset coming out of this loss?

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