Guest: Sabrina Fabi, MD, FAAD, FAACS

Guest: Neil Sadick, MD

Poly-L lactic acid (PLLA/Sculptra® Aesthetic) is the only injectable in its class. It has unique characteristics that need to be clearly understood and integrated into injection techniques before injectors reach optimal results and avoid adverse events. PLLA is approved by the FDA for a single regimen for the correction of shallow to deep nasolabial fold contour deficiencies and other facial wrinkles in which deep dermal grid pattern (cross-hatch) injection technique is appropriate. However, it is clear from discussions with expert injectors (and peer-reviewed literature) that PLLA is being utilized in a number of areas outside of the approved use. As a result, training is needed throughout the cosmetic injection community to emphasize safe and appropriate injection techniques that will lower adverse effects and improve patient outcomes.

Guest: Matt T. Rosenberg, MD

Thirty-three million people in the United States suffer from overactive bladder but most people will not discuss it. Join Dr. Rosenberg as he discusses OAB, the adverse consequences and burden of this disease, barriers to effective patient-physician communication, and available treatment options. He will also discuss barriers to patient adherence and how such barriers may be effectively addressed. This presentation was recorded live at From Guideline to Practice: Managing Challenging Cases in Primary Care in New York, NY in September 2016.

Host: Barnett Mennen, MD

Guest: Meenhard Herlyn, DVM, DSc

Melanomas are among the most genetically abnormal malignancies with hundreds or even thousands of mutations. In this activity, Dr. Meenhard Herlyn discusses updates on resistance from the 13th International Congress of the Society for Melanoma Research that took place recently in Boston, Massachusetts. Topics include, therapy strategies that benefit from many mutations, how melanomas adapt to growth outside of the human host, and their response to MAPK inhibitors. He will also discuss tumor heterogeneity and drug resistance and why checkpoint inhibitors and kinase inhibitors are ideal for combination therapies.

Host: Barnett Mennen, MD

Guest: Michael Postow, MD

Immunotherapy, notably overcoming checkpoint inhibition, has become an integral part of treatment for melanoma, if not a growing list of other cancers. In this activity, Dr. Michael Postow discusses major updates on the use of immunotherapy in melanoma as presented at the 13th International Congress of the Society for Melanoma Research that took place recently in Boston, Massachusetts. Topics include the general mechanistic principles behind immune checkpoint blockade in the treatment of metastatic melanoma; the current landscape of immune checkpoint inhibitors; and considerations for single agent vs. combination immunotherapy. Additionally, Dr. Postow will address the current value of immunotherapy biomarkers in patient selection and the independent and/or combined roles of immunotherapy and targeted therapy in the treatment of melanoma.

Host: Brian P. McDonough, MD, FAAFP

Guest: Matt T. Rosenberg, MD

Overactive bladder (OAB) is associated with significant morbidity and is recognized as a significant health issue, affecting 16.5% of U.S. adults. Despite a high rate of prevalence, OAB remains under-diagnosed. In this activity, we will discuss communication methods for proper engagement in a discussion about OAB with your patients and recommended treatment options.

Host: Karen E. Taylor, MD, FACOG

Guest: Charles S. Cox Jr., MD

Regenerative medicine is focused on the replacing or "regenerating" of human cells, tissues or organs, so as to restore or establish normal function. Cord blood stem cells are currently being researched for their regenerative utility for issues such as brain injury, hearing loss, autism, diabetes, and congenital heart disease. What are the current and future applications for cord blood in this field?

Host: Patrice L Basanta-Henry, MD, MHSc, FACOG

Reports indicate that there is a national upsurge in the number of women with opioid addiction. The problem is multigenerational, with consumption habits that begin as early as the mid-teenage years and extend well into the elderly population.

Additionally, opioid addiction disproportionately affects women, who are more likely to become dependent and overdose unintentionally on painkillers compared to men.

Host Dr. Patrice Basanta-Henry talks with Dr. Regan Theiler, Director of the Division of General OB/GYN at Dartmouth-Hitchcock Medical Center about treatment approaches for opioid-addicted pregnant women and women of childbearing age.

Host: David L. Bell, MD, MPH

Human Papillomavirus Vaccine Uptake in Adolescent Boys: An Evidence Review Voss DS1, Wofford LG2. Worldviews Evid Based Nurs. 2016 Jul 26. doi: 10.1111/wvn.12172. [Epub ahead of print] Abstract BACKGROUND:Despite evidence-based guidelines recommending routine vaccination against human papillomavirus (HPV) for adolescent boys, ages 11-12 years, vaccine uptake among this population remains low. AIMS:To examine reasons for low HPV quadrivalent vaccine uptake and methods available to increase vaccine uptake among adolescent males, ages 11-12 years. METHODS AND RESULTS:Of 341 identified studies, 30 were included from three databases. The 30 studies were grouped into six categories: population-specific, problem-specific, educational interventions, theory-specific, political implications, and foundational guidelines and Websites. DISCUSSION:Among eight studies, low vaccine uptake was attributed to lack of parental, adolescent, and physician knowledge of HPV4 vaccine availability and recommendations. HPV4 vaccine educational interventions for parents and adolescents were the most effective for promoting vaccine uptake. Theory applications and gain-framed messages were shown to be effective for assessing HPV vaccine attitudes and perceptions. Political implication studies reveal the need for political and financial measures to encourage HPV vaccine acceptability among the population. IMPLICATIONS FOR CLINICIANS:To promote HPV vaccine uptake among adolescent males, providers must remain current with HPV vaccine recommendations and offer parental ...

Host: Brian P. McDonough, MD, FAAFP

Guest: David L. Bell, MD, MPH

There continues to be significant barriers to vaccine adoption among both practitioners and the parents of some children and adolescents. In this activity, we will discuss the barriers for adoption, as well as why it is important to improve immunization rates among teens and adolescents, in particular the HPV vaccine. We will also discuss educational strategies and national policy positions that have improved vaccination uptake.

Host: Barnett Mennen, MD

Guest: Erin McElroy Barker, LCSW

Patients with cystic fibrosis and their families are at a higher risk for mental health issues which have been associated with other complications. In this activity, Ms. McElroy Barker will discuss how the CF community recognized the need for mental health services and the guidelines the CF Foundation recommends for screening patients.