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Popular examples of OTC drugs include pain relievers such as acetaminophen (Tylenol) and ibuprofen (Motrin, Advil), cough suppressants like dextromethorphan (Robitussin) and antihistamines such as loratadine (Claritin 24H). 

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Nonsteroidal anti-inflammatory drugs (NSAIDs), such as high-dose aspirin, Ibuprofen (Advil, Motrin, Midol) and Naproxen (Aleve, Naprosyn) are the best OTC drugs for reducing inflammation. 

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OTC stands for over-the-counter drugs. They are medications you can purchase without a prescription from a doctor.

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In order to obtain the FDA's approval to change the classification of a prescription drug to OTC, the manufacturer of the product must demonstrate its safety and efficacy. Generally, drugs can become OTC if they can be used safely and effectively without instructions from a health care provider.

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A standard dose of Nyquil wouldn't do anything other than make you sleepy. However, DXM is a dissociative drug at higher doses and will definitely keep you awake and high. 

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Although the average dose of Nyquil lasts for around 4 to 6 hours, doxylamine may have a significantly larger range of effects. Depending on the person, its effects can last anywhere between 3 to 8 hours. 

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If you just consumed a drink, you should not take NyQuil for at least an hour. On the other hand, since NyQuil lasts about 4 to 6 hours per dose, you should wait for that period to pass before having a drink.

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NyQuil and alcohol should never be combined. Doing so can bring about unpleasant short-term side effects and, in some cases, lead to more serious long-term effects. 

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Technically, NyQuil can be taken during the day, but it can cause the user to feel tired and drowsy. Hence, it's best to take it at night, or if you have planned to stay home for the rest of the day.

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The primary component of NyQuil is Doxylamine Succinate, which is an antihistamine that causes drowsiness by obstructing histamine from binding to the brain receptors.

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