Maximizing patient safety and reducing diagnostic errors is rooted in a quality management approach. The manual Quality Management in Anatomic Pathology (https://capatholo.gy/2UNJ9lk) provides pathologists and laboratory directors with the tools necessary to implement a comprehensive quality program, with an emphasis on regulatory compliance and cross-references to the CAP Laboratory Accreditation Program checklists and CLIA. In this CAPcast, one of the book’s co-authors, Dr. Gene Siegal, discusses the challenges related to quality, the common causes of error, and the key elements of a comprehensive quality program.