Let’s talk about a potential new high-tech mine in Minnesota, how scientists have created a synthetic mouse embryo using stem cells, and a major breakthrough in the cause of and treatment for Down Syndrome.  

Remote Mines

• “This Remote Mine Could Foretell the Future of America’s Electric Car Industry” by Ana Swanson
  • https://www.nytimes.com/2022/08/30/business/economy/electric-cars-us-nickel-mine.html
• “Fight over Minnesota nickel mine plan by Talon Metals is local — and global, too” by Mark Reilly
  • https://www.bizjournals.com/twincities/news/2022/08/31/talon-metals-nickel-mine-minnesota.html

Mouse Embryos 

• “Scientists Use Stem Cells To Create Synthetic Mouse Embryos” by Associated Press
  • https://www.nbcnews.com/science/science-news/scientists-use-stem-cells-create-synthetic-mouse-embryos-rcna44881
• “Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs” by Shadi Tarazi, Alejandro Aguilera-Castrejon, Carine Joubran, Nadir Ghanem, Shahd Ashouokhi, Francesco Roncato, Emilie Wildschutz, Montaser Haddad, Bernardo Oldak, Elidet Gomez-Cesar, Nir Livnat, Sergey Viukov, Dmitry Lokshtanov, Segev Naveh-Tassa, Max Rose, Suhair Hanna, Calanit Raanan, Ori Brenner, Merav Kedmi, Hadas Keren-Shaul, Tsvee Lapidot, Itay Maza, Noa Novershtern, and Jacob H. Hanna
  • https://www.cell.com/cell/fulltext/S0092-8674%2822%2900981-3

Down Syndrome Treatment

• “Hormone that could improve cognitive function in Down syndrome identified” By Helen Floersh
  • https://www.fiercebiotech.com/research/scientists-have-identified-hormone-could-restore-cognitive-function-down-syndrome#:~:text=Now%2C%20a%20team%20of%20researchers,it%20could%20improve%20cognitive%20performance.
• “GnRH replacement rescues cognition in Down syndrome” by MARIA MANFREDI-LOZANO et al.
  • https://www.science.org/doi/10.1126/science.abq4515

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Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/remote-mines-mouse-embryos-down-syndrome-treatment

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