In this episode David Leverenz, Aki Udupa, Didem Saygin, and Guy Katz introduce the first half of the RheumMadness bracket.  The second half will be covered in the next episode (Bracketology Part 2).  You can learn more about RheumMadness here: https://sites.duke.edu/rheummadness/

References for topics discussed in this episode
Belimumab for Lupus Nephritis: Furie et al. NEJM.2020;383(12):1117-28 (pubmed link)
Anifrolumab for SLE: TULIP-1 and TULIP-2 trials (click for links)
PEXIVAS in ANCA Vasculitis: Walsh et al. NEJM.2020;382(7):622-31 (pubmed link)
Avacopan in ANCA Vasculitis: Jayne et al. NEJM.2021;384:599-609 (NEJM link)
IgG4-RD Classification Criteria: Wallace et al. A&R.2020;72(1):7-19 (pubmed link)
Relapsing Polychondritis (RP) Subtypes: Ferrada et al. A&R.2020;72(8):1396-1402 (pubmed link)
Anti-CD38 in Refractory SLE: Ostendorf et al. NEJM.2020;383(12):1149-55 (pubmed link)
VEXAS: Beck et al, NEJM.2020;383:2628-38 (pubmed link)

Intro and Outro music:
Cheery Monday by Kevin MacLeod
Link: https://incompetech.filmmusic.io/song/3495-cheery-monday
License: http://creativecommons.org/licenses/by/4.0/

In this episode we welcome Dr. Didem Saygin, a rheumatology fellow from the University of Chicago, to the podcast.  We are also joined by Dr. Guy Katz, a rheumatology fellow from MGH.  We discuss three more topics that would be excellent teams in the upcoming RheumMadness tournament: the newly discovered VEXAS autoinflammatory syndrome, the FAST trial on cardiovascular safety of urate-lowering therapies, and the PEXIVAS trial in ANCA vasculitis.

New RheumMadness website!
https://sites.duke.edu/rheummadness/

References:
VEXAS: https://www.nejm.org/doi/full/10.1056/NEJMoa2026834
FAST: https://www.thelancet.com/article/S0140-6736(20)32234-0/fulltext
PEXIVAS: https://www.nejm.org/doi/full/10.1056/NEJMoa1803537

RheumMadness Music Attribution: Cheery Monday by Kevin MacLeod
Link: https://incompetech.filmmusic.io/song/3495-cheery-monday
License: http://creativecommons.org/licenses/by/4.0/

In this episode we welcome guests Dr. Akrithi Udupa and Dr. Allen Witt from Duke, and Dr. Guy Katz from MGH to discuss four topics from the 2020 ACR Convergence conference that could be teams in the upcoming RheumMadness tournament.  The topics we discuss are:
1. Draft 2020 RA Guidelines
2. Belimumab for Lupus Nephritis
3. Pregnancy with ILD in Rheumatic Disease
4. IL-16 as a Biomarker of Lupus Nephritis

RheumMadness Music Attribution: Cheery Monday by Kevin MacLeod
Link: https://incompetech.filmmusic.io/song/3495-cheery-monday
License: http://creativecommons.org/licenses/by/4.0/

Dr. Aki Udupa and Dr. Allen Witt are back to discuss:
-Rheuminders from the previous episode on relapsing polychondritis subtypes
-Primer on RA pathophysiology
-A new study (see below) using longitudinal genomics to provide new insights into the pathogenesis of RA flares and describing a new type of cell: PRIME cells.

Reference: Orange DE, Yao V, Sawicka K, Fak J, Frank MO, Parveen S, Blachere NE, Hale C, Zhang F, Raychaudhuri S, Troyanskaya OG, Darnell RB. RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares. N Engl J Med. 2020 Jul 16;383(3):218-228. doi: 10.1056/NEJMoa2004114. PMID: 32668112; PMCID: PMC7546156.

Intro and Outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

This episode includes:
-Rheuminders from the previous episode on IgG4-RD classification criteria
-Primer on relapsing polychondritis
-Discussion of a new paper (see below) describing 3 clinical subtypes of relapsing polychondritis

Reference: Ferrada M, Rimland CA, Quinn K, Sikora K, Kim J, Allen C, Sirajuddin A, Goodspeed W, Chen M, Grayson PC. Defining Clinical Subgroups in Relapsing Polychondritis: A Prospective Observational Cohort Study. Arthritis Rheumatol. 2020 Apr 6. doi: 10.1002/art.41270. Epub ahead of print. PMID: 32249511.

Intro and Outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

Dr. Akrithi Udupa (fellow at Duke) and Dr. Allen Witt (resident at Duke) join the podcast to discuss IgG4-RD and the new classification criteria published by Wallace et al in Arthritis & Rheumatology in January 2020.

Reference: Wallace et al. The 2019 American College of Rheumatology / European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis & Rheumatology. 2020;72(1):7-19.

Intro and Outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

Introduction to the RheumMadness Podcast!

Intro and Outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/