Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we have three new and interesting research papers to look at. 

First, hitting the headlines this week, weight regain after cessation of GLP1 receptor agonists. Not a surprise, perhaps, but how fast does the weight come back, can anything be done to prevent it, and what are the implications for patients and the NHS?

Second, orforglipron - the new GLP1ra on the block and an oral treatment. Can it help weight loss and improvement in cardiometabolic markers in patients with obesity and type 2 diabetes? 

Finally, which is better for treating scabies - permethrin or oral ivermectin? Would a tablet be an easier option, or is it just not as good? 

References

BMJ Weight regain after cessation of weight loss medications

BMJ Editorial

BMJ Opinion 

BMJ Side Effects of GLP1ras

NEJM Orforglipron RCT in obesity

Lancet Orforglipron RCT in obesity and T2DM

BMJ Scabies treatment - ivermectin or permethrin?

PCDS Scabies guideline

BAD Scabies guideline

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