ME – also known as Chronic Fatigue Syndrome – has long been one of medicine’s most perplexing conditions. With no definitive diagnostic test and a legacy of scepticism in parts of the medical community, patients have often struggled to be believed. But a surge of new research may finally be shifting the landscape.

In this episode, James Gallagher speaks to Dr Chris Ponting about the latest DecodeME results, which point to a strong genetic component to ME. And Professor Rosemary Boyton outlines the ambition behind the new Rosetta Stone study, designed to build a detailed evidence base of shared biomarkers across ME and Long COVID.

Presenter: James Gallagher

Over 1.5million adults in the UK tried weight loss drugs in 2024-25. Many swear by them, but they have been associated with side effects including nausea and, in some cases, extremely painful gallstones. But what does the evidence actually tell us, and what is the wider impact on the way we view our bodies in society?

James Gallagher is joined by Professor of Cardiometabolic Medicine at the University of Glasgow Naveed Sattar, Dr Beverley O’Hara, Lecturer in Public Health Nutrition at Leeds Beckett University, and Dr Margaret McCartney, resident Inside Health GP. They discuss what the evidence tells us about the potential known side effects of these weight loss drugs, and the potential impact their use has on our view of obesity as a society. We also hear from Sarah Le Brocq, who has struggled with obesity all her adult life and has been on these drugs for the past 2-3 years about her experiences.

Margaret McCartney has no conflicts of interest to declare.

Beverley O’Hara has no conflicts of interest to declare. She has 2 roles with the Association for the Study of Obesity (voluntary academic positions).

Naveed Sattar has consulted for and/or received speaker honoraria from AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Carmot Therapeutics, Eli Lilly, Gan & Lee, GlaxoSmithKline, Hanmi Pharmaceuticals, Kailera, Mass Medicines, Menarini-Ricerche, Metsera, Novo Nordisk, Pfizer, Regeneron, Roche, UCB Pharma, and Verdiva Bio; and received grant support paid to his University from AstraZeneca, Boehringer Ingelheim, Novartis, and Roche.

Presenter: James Gallagher

Dentistry is high on the public and political agenda. There have been dozens of headlines about access to NHS dentistry, with some people having to travel huge distances to find a dentist, or being put onto long waiting lists to get an NHS appointment.

In this episode of Inside Health, James Gallagher is joined by chairman of the British Dental Association Eddie Crouch, the Oral Health Foundation's Dr Rachael England, and consultant oral surgeon Tom Thayer. Together, they drill into the issues surrounding NHS dentistry. Along the way, they discuss possible solutions, whether contract reforms will help, and the potential future of dentistry in the UK.

Presenter: James Gallagher

Most of us have Epstein-Barr Virus (EBV) hiding in our bodies.

You may know it as the cause of glandular fever or “kissing disease”.

But more research is suggesting that it can turn our immune systems against us to cause autoimmune disease, such as multiple sclerosis or lupus.

James is joined by Dr Claire Shannon-Lowe, a virologist at the University of Birmingham, and Dr Patrick Kearns from the University of Edinburgh, a neurologist and epidemiologist.

And we delve into the world of echolocation.

Bats hunt at night by making pulses of sounds and listening to the echoes so they can build a picture of the world around them in total darkness - and it's a technique some people with visual impairment use to explore the world.

A team at the University of East Anglia has been testing how well humans can pick up these skills, so James pays a visit to have a go...

Presenter: James Gallagher

This week we’re looking at government plans to start sequencing the DNA of every newborn baby in England within the next decade.

Each newborn would undergo whole genome sequencing to assess their risk of hundreds of diseases, under NHS plans.

It promises a revolution in spotting disease early - but are there also risks?

And use of nicotine pouches is rising, especially among young men.

But these little sachets that fit under the top lip aren’t yet regulated – so what do we know about the potential harms?

Finally, as the cold weather continues, James gets a lesson in walking like a penguin to see if it helps avoid trips, slips and falls…

James Gallagher stands by four lanes of traffic and inhales exhaust fumes all to see if he can see air pollution in his body. He looks at an intriguing finding that an mRNA vaccine might benefit people being treated with immunotherapy for some cancers and could we be on the cusp of a holy grail in dentistry? A breakthrough could mean we will soon be able to replace the enamel on our teeth.

Saunas are popping up all over the country, with many people claiming they relax muscles and help ease stress. But what does the science say? This week, James Gallagher travels to Môr A Sawna in Jackson’s Bay, Barry, where he treats himself to a sauna session and undergoes a number of physical tests to find out what benefits the sweaty heat could offer.

Next up, James visits The Advanced Neuropathies Centre in Cardiff to speak with Professor Liam Gray, a surgeon who is leading a pioneering treatment for Huntington’s disease.

Presenter: James Gallagher

This episode was produced in partnership with The Open University.

In 1964, the future for children born with Cystic Fibrosis was grim - most faced a life cut tragically short. Today, the majority of people living with CF in the UK are adults, a testament to extraordinary medical progress.

We meet Annabelle who lives with Cystic Fibrosis, and once believed she might not see her 18th birthday. And we hear from Dr Imogen Felton, a respiratory consultant at Royal Brompton Hospital, with expertise in cystic fibrosis, who tells us about the therapies crucial to this extended prognosis.

The EDITH trial (Early Detection using Information Technology in Health) is testing how AI can help radiologists identify breast cancer at an earlier stage, transforming the future of diagnosis. We speak to Professor Sian Taylor-Philips, Professor of Population Health at the University of Warwick and co-leader of the trial.

In 2024, participation in Run Clubs across the UK surged by 64%. But does running in a group lead to better performance? To find out, James laces up for a jog around Hyde Park with the Monday Mood Booster Run Club and speaks with Arran Davis, a postdoctoral researcher at the University of Oxford, who’s exploring the links between social interaction and physical activity.

Presenter: James Gallagher

Dementia is now the UK’s leading cause of death - but could a vaccine one day help prevent it? New data from Wales suggests the shingles vaccine is linked to a 20% lower risk of developing dementia in later life, adding to evidence that viral infections can influence brain health.

Dr. Pascal Geldsetzer, Assistant Prof of Medicine at Stanford University discusses his findings and the further evidence required to prove this link, along with Prof Tara Spires-Jones, Group Leader in the UK Dementia Research Institute.

The UK has begun using the world’s first gonorrhoea vaccine - though it was originally developed for meningitis. With antibiotic-resistant strains increasing, we speak to Dr Suneeta Soni about why gonorrhoea has been so hard to target with vaccines.

At the Bristol Robotics Lab, engineers are creating devices to support mobility in older age. James meets Jonathan Rossner and tries out “The Right Trousers” - an inflatable exoskeleton designed to help people walk and to strengthen their muscles.

Presenter: James Gallagher

More and more parents are using melatonin to help their children sleep - but there is little research on the long-term effects.

So, what do we know about the risks and is it ok to give it to children as an aid to help sleep?

James chats to Paul Gringras, professor of children’s sleep medicine and neurodisability at Guy’s and St Thomas’ NHS Foundation Trust and Vicki Beevers, chief executive of The Sleep Charity.

Also this week, resident GP Margaret McCartney on the potential promise - and peril - of doctors using AI in the NHS, and should you eat your placenta? We hear from a dietician on whether there’s any evidence it’s good for you.

Presenter: James Gallagher

This episode was produced in partnership with The Open University.