Dean Lloyd Minor welcomes Meena Seshamani, MD, PhD, director of the federal Center for Medicare at the Centers for Medicare & Medicaid Services, for a conversation about supporting holistic health care through the country’s government insurance program for seniors. They discuss Medicare’s role in advancing prescription drug affordability and the importance of family caregivers and community workers in helping seniors attain their optimal health. They also explore practical approaches Medicare has deployed to advance health equity, and discuss what needs to be done to ensure the program’s financial strength and viability for generations to come.