Penelope Morel and James Faeder discuss their finding that the duration of T cell receptor signaling determines the fate of regulatory versus helper T cells.

Walter Koch explains how S-nitrosothiols protect heart cells from ischemia-induced cell death.

Ariel Feldstein discusses the identification of microparticles released by fat-laden hepatocytes that stimulate angiogenesis and contribute to the progression of fatty liver disease.

Carlos Gorbea discusses how a subset of proteasomes attenuates TLR3-mediated antiviral signaling.

Martin Miller and Chris Sander discuss combining a drug screen and network modeling to identify a potential combination therapy for lipsarcoma.

Peter Parker, Mark Linch, and Neil McDonald discuss a motif in an atypical protein kinase that mediates interactions with cell polarity substrates and is mutated in some cancers.

Ken Irvine and Gongping Sun explain how JNK signaling leads to nuclear accumulation of the transcription factor Yorkie through phosphorylation of an adaptor protein.

Peixin Yang and Albert Reece discuss the critical role a proapoptotic kinase plays in the development of neural tube defects associated with maternal hyperglycemia.

Diomedes Logothetis and Rahul Mahajan explain how G proteins activate a potassium channel to slow heart rate.

Douglas Lauffenburger discusses how amplification of the receptor tyrosine kinase AXL promotes migration of triple negative breast cancer cells.