Daniel Davis explains how the distribution of an inhibitory receptor on the surface of natural killer cells changes when an activating receptor is engaged.

Paul DiCorleto explains how nonmuscle myosin limits proinflammatory signaling by tumor necrosis factor receptor 2.

Keqiang Ye discusses a small molecule inhibitor of the kinase JAK2 that blocks proliferation of glioblastoma cells.

Kari Alitalo discusses experiments that reveal how two related VEGF ligands trigger distinct biological outcomes by binding to the same receptor.

Brian Button discusses a feedback mechanism for insuring the proper hydration of airway mucus.

The tyrosine kinase BMX may act as a global promoter of maximal receptor tyrosine kinase activity.

A deubiquitinase helps control the inflammatory response.

Calcium signaling is required for long-term memory in fruit flies.

The chemokine scavenging activity of an atypical chemokine receptor requires signaling through β-arrestin.

Analysis of VEGF signaling identifies potential therapeutic strategies for treating pathological angiogenesis.