The 2012 Nobel Prize in Chemistry honors research on the function of G protein–coupled receptors.

A lipid signaling enzyme promotes the growth, vascularization, and metastasis of tumors in mice.

Mice lacking an inhibitory receptor have defects in the number, size, and function of platelets.

A growth signal can mediate feedback that reduces cell proliferation and stem cell self-renewal.

The neurotrophic factor BDNF has opposite effects on cocaine- and morphine-induced neuroplasticity.

The activity of a lipid kinase influences the production of invadopodia by cancer cells.

A protease can help protect against neurodegeneration by preventing inflammation in microglia.

Growth of the male rhinoceros beetle’s horn is more sensitive to insulin signaling than are other body parts.

Drugs that reduce microtubule density or prevent the production of reactive oxygen species in skeletal muscle might slow the progression of Duchenne muscular dystrophy.

A scaffolding protein enables clustering of IgG B cell receptors to promote antibody secretion by memory B cells.