A transcription factor protects the heart from radiation-induced damage.

Structural analysis reveals how a Wnt binds to its receptor.

An inhibitory receptor blocks proliferation of autoreactive T cells to promote tolerance in the periphery.

Modification of a bound lipid modulates the activity of a nuclear receptor.

Regulated nuclear translocation of a transcription factor maintains lysosomal homeostasis.

Interferon-β therapy is only effective in treating a mouse model of multiple sclerosis when the disease is dependent upon the NLRP3 inflammasome.

Maximal blood vessel dilation can be induced by calcium influx through a just few channel molecules in vascular endothelial cells.

Receptor tyrosine kinases existed in the unicellular ancestors of multicellular animals and underwent diversification in the metazoan lineage.

New findings elucidate mechanisms by which astrocytes can modulate neuronal activity.

Rapamycin’s effects on longevity and insulin sensitivity are mediated by different molecular targets.