A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila.

Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling.

By working together, cells can overcome the loss of information as it flows through a signaling network.

Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells.

Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade.

Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation.

β2 subunit-containing nicotinic acetylcholine receptors in the prefrontal cortex are sufficient for acetylcholine-mediated enhancement of attentional focus.

Opioid receptors stimulated with morphine signal less efficiently than those stimulated with an endogenous opioid peptide.

A cell-based, high-throughput screen identifies activators and inhibitors of invadopodia formation.

The anti-inflammatory effects of chloroquine are mediated by inhibition of the lysosome, which enhances glucocorticoid signaling.