Two studies shed light on cell cycle-dependent protein phosphorylation during mitosis in yeast.

Structural analysis reveals how increasing concentrations of monomeric actin prevent a transcriptional coactivator from promoting expression of target genes.

Recent research reveals details about the regulation and activity of the Hippo signaling mediator Yap.

Two related ligands that activate the same receptor have different effects on immune system stimulation and inflammation.

A growth factor that antagonizes signaling by tumor necrosis factor α relieves symptoms of inflammatory arthritis.

The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors.

Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl.

A protein required for light sensation also plays a role in thermosensing in the fruit fly.

Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells.

A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli.