Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons.

Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling.

Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast.

Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins.

Targeting interactions between HLA-I and the integrin beta4 subunit is a potential strategy for preventing transplant rejection.

A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease.

Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy.

Inhibition of Apolipoprotein-E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke.

A phosphoprotemic approach identifies potential targets for developing combination therapies to treat cancer.

A virally-encoded G protein-coupled receptor promotes cellular proliferation and vascularization.