This short story is about addiction. And Muppets.

Host Meg Wolitzer presents three pieces about losing things: objects, opportunities, a primary sense, a new friendship. In “Any Other” by Jac Jemc, performed by Helen Hong, a woman rejects an offer without knowing the consequences. Namwali Serpell’s “Noseless” is about a loss many experienced during the pandemic; it’s performed by Kyrstina Alabado, Deborah S. Craig, Zach Grenier, and Calvin Leon Smith. And Lauren Groff’s “Such Small Islands” charts the perilous course of a childhood infatuation and betrayal that ends with figurative loss and a literal disappearance. It’s performed by Crystal Dickinson. In a special bonus: multi-instrumentalist Laura Gibson performs a song inspired by Groff’s story.

Host Meg Wolitzer presents three stories about characters who try to prepare for trouble, sometimes doing more harm than good. In Joe Meno’s “Animal Hospital” a well-meaning father is surprised by his kids’ response to a game of doctor. The reader is Becky Anne Baker. An interview with Meno is featured in the show. In “The Silk Handkerchief,” by Sait Faik Abasiyanik, a thief and a night watchman have a moment of rapport. It’s read by Amir Arison. And Margaret Atwood’s recurring couple Nell and Tig try to stave off the inevitable by taking a “First Aid” class. The reader is Maggie Siff. Margaret Atwood introduces the story from the stage.

Guest host David Sedaris presents stories that reimagine holiday rituals. In Tobias Wolff’s “Powder,” a pre-Christmas snowstorm provides an adventure for a father and son. SELECTED SHORTS’ late host and founder Isaiah Sheffer is the reader. A long-established couple turn out to be able to surprise one another in Allegra Goodman’s gentle borrowing from an O. Henry classic. Dana Ivey and Michael Cerveris read her “Gifts of the Jewish Magi.” And David Sedaris says English writer Jeanette Winterson captures the city to a “T” in “Christmas in New York,” a modern fairy tale with just a hint of magic, performed by Richard Masur.

Host Meg Wolitzer presents four stories about journeys, performed by actors including Stephen Colbert and John Turturro. Strangers size one another up on a busy city bus in Kurt Vonnegut’s “City,” performed by Bhavesh Patel and Sarah Steele. An excerpt from James Baldwin’s Another Country takes us on a frantic subway ride toward an ultimate moment. It is performed by Nathan Hinton. Hopeful immigrants try to reach America in a dubious boat in “The Long Voyage” by Leonardo Sciascia, performed by John Turturro. And a man in transit takes the opportunity to try to recover a bit of his past, in F. Scott Fitzgerald’s “Three Hours Between Planes,” performed by Stephen Colbert.

Host Meg Wolitzer helps a great documentarian celebrate a great American author. Cather, author of novels like My Antonia and O Pioneers! just had her sesquicentennial—her 150th birthday. And Burns hosted a live evening of her shorter works. On this program, we feature “The Way of the World,” in which an imaginary town’s young “citizens” are rife with romance and rivalry. The reader is Sonia Manzano. And a weary farmer’s wife recaptures her long-dormant passion for music at “A Wagner Matinee,” read by David Strathairn.

Host Meg Wolitzer presents three stories that ask the big, basic questions: Who? What? Where? The characters resonate, the situations are intriguing, and each offers a fully realized world. In “What Animal Are You?,” by Etgar Keret, performed by Willem Dafoe, a celebrity writer and his son play themselves for the media. In Rumaan Alam’s “Nothing Can Come Between Us,” performed by Nathan Hinton, a man goes into sensory overdrive. And a fierce and traditional grandmother tries to find her place in a new world and a new family in Gish Jen’s “Who’s Irish?” performed by Frieda Foh Shen.

Host Meg Wolitzer presents three stories about finding solutions to complex problems, and to simple ones. T. C. Boyle tackles evolution and government intervention in “Top of the Food Chain,” read by Zach Grenier. In Matthew Ryan Frankel’s “Carapace,” a young boy struggles with feelings at a family funeral—with the help of some crabs. The reader is Philip Estrera. And a young woman traveling between two worlds and two families has to deal with what to put in “The Suitcase” by Meron Hadero. The reader is Renée Elise Goldsberry. The show also includes an interview with Hadero.

Host Meg Wolitzer presents two stories about indomitable women. A mother grieves a loss fiercely in Carribean Fragoza’s “Lumberjack Mom,” performed by Roberta Colindrez. And Richard Yates’ classic “Fun with a Stranger” offers a portrait of an unforgettable teacher. It’s performed by Marian Seldes.

Host Meg Wolitzer presents three works about women who defy the status quo and might therefore be perceived as “dangerous” in this encore presentation. In Margaret Atwood’s “Unpopular Gals,” fairy-tale archetypes reclaim their power. The reader is Ann Harada. A boisterous and brilliant student threatens to upend the order of her high school in Shanteka Sigers’ “A Way with Bea,” performed by Pascale Armand. And a Victorian-era wife fights for her sanity in Charlotte Perkins Gilman’s classic “The Yellow Wallpaper,” performed by Carrie Coon. The show also includes commentary by journalist and activist Mona Eltahawy.