This episode is a total revamp of the previous episode on sepsis. A lot has changed with sepsis management since I published the sepsis episode in February 2012 so it was time for a complete overhaul. The new sepsis guidelines have been out for about a year and I finally got around to updating the episode. This episode will discuss the recognition of sepsis, how to do a good physical exam and ask the right history questions, order the right tests, and aggressively resuscitate these very sick patients. There is a separate episode that discusses the old sepsis definitions and how you can use that framework to recognize sepsis.