63. Why a Museum Dose Might Be Your Ideal First Trip

Curious about how to dose your magic mushrooms without overdoing it? This episode of The High Guide explores the increasingly popular “museum dose”—a sweet spot between microdosing and macrodosing. Host April Pride returns to a listener favorite: episode 43 on how to find your ideal psilocybin strain and dose. In this latest drop, she digs into why certain potent shroom strains, like Albino Penis Envy and Blue Meanies, are ideal for creative, lightly altered experiences that won’t get you booted from a gallery (well, probably). You’ll also hear trip tips, a strain review, and a surprising insight from new research on body weight and dosage.

🔵 Key Takeaways

-A museum dose typically ranges from 100–500mg and is ideal for socializing, nature walks, or light introspection.

-Potent strains like Albino Penis Envy and Blue Meanies deliver more with less, making them museum dose favorites.

-You don’t need to adjust mushroom dosage based on body weight—fixed doses are just as effective.

-Blue Meanies exist in two species: Psilocybe Cubensis and Panaeolus cyanescens—know which one you're taking.

-Tolerance is real: microdosers may benefit from rotating strains or increasing potency over time.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/what-is-a-museum-dose-psilocybin

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

62. Cannabis Social Equity, Psilocybin Reform & the Drug War’s Legacy

In this sweeping episode of The High Guide, April Pride draws a potent line from past to present—tracing how U.S. drug policy has historically harmed communities of color and how cannabis and psychedelics are reshaping that narrative. With guests like Raeven Duckett and Lee Maddox, April dives into the origins and impact of cannabis social equity programs, the racial disparities in drug enforcement, and why the psychedelic renaissance must not replicate cannabis' blind spots. The episode also offers a deep-dive review of Liberty Cap mushrooms and practical trip tips for anyone on a healing journey.

🔵 Key Takeaways

-Oakland pioneered cannabis equity licenses to support communities harmed by the war on drugs.

-Despite legalization, Black and Latino people still face disproportionate cannabis arrests.

-Meth’s evolution into P2P form explains today’s mental health crisis on city streets.

-Psilocybin is gaining traction as a trauma treatment, especially for veterans and first responders.

-Liberty Caps are potent psilocybin mushrooms—great for experienced users, not beginners.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/cannabis-equity-psychedelic-reform-today

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

61. Albino Penis Envy Mushroom: Trip Tips, Potency & Safety for Women

What happens when you take one of the most potent mushroom strains known to modern psychonauts? In this episode of The High Guide, April Pride dives into albino penis envy mushroom—the legendary “APE”—offering firsthand insights and community wisdom on how to approach this strain safely and meaningfully. She unpacks what happened at her live Q&A event in Seattle on psilocybin trip safety and shares practical trip tips for women, especially those microdosing or navigating midlife. You'll hear why alcohol and mushrooms don’t mix, how ovulation timing can deepen your journey, and why set and setting matter even more when the mushrooms are this strong.

🔵 Key Takeaways

-Albino penis envy is 3–4x more potent than golden teacher mushrooms and is not recommended for beginners.

-Set, setting, and music are crucial—especially when the emotional intensity of the trip is high.

-Women may benefit from syncing psilocybin use with their ovulatory phase for a more grounded and energetic experience.

-Museum doses (250–500mg) are a safer entry point for exploring this strain solo.

-Alcohol and psychedelics don’t mix—especially with potent mushrooms like APE.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/albino-penis-envy-mushroom

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

60. Ecuador Psilocybin Strain: A Mother's Day Mushroom Guide

In this solo episode of The High Guide, host April Pride records on-the-go and off-the-cuff, sharing an intimate and insightful dive into the Ecuador psilocybin strain. Tied to her own healing journey and Mother's Day reflections, this episode explores what makes this particular mushroom stand out—especially for women seeking gentle transformation. You’ll get a crash course in fruiting bodies, preparation tips like psilocybin tea, and what it means to feel “lifted” versus “tripping.” Plus, April shares her experience leading Q&A events in Seattle that help demystify psilocybin for moms. It’s not polished, but it’s potent—just like the strain itself.

🔵 Key Takeaways

-The Ecuador psilocybin strain is known for potent, serene effects—ideal for emotional release or everyday wonder.

-Whole fruit bodies may offer fuller benefits than extracts; learn how to prep and dose safely.

-April’s psilocybin tea ritual offers a clear, embodied alternative to higher-dose journeys.

-Q&A events in Seattle give women a safe space to explore psilocybin for motherhood and mental health.

-Microdosing with this strain supports mindfulness, movement, and lighter emotional loads.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/ecuador-psilocybin-strain-moms

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

59. Golden Teacher Mushroom: Your First Psychedelic Trip Starts Here

Thinking about trying psychedelics for the first time? Golden Teacher Mushrooms—affectionately known as GT—might be your best first step. In this episode of SetSet, host April Pride takes us deep into the golden glow of this beginner-friendly strain. With insights from psychedelic guide Natasha Lannerd, April shares what makes Golden Teacher the “Fisher Price” of psilocybin mushrooms: not too strong, not too long, but just right. Expect grounded wisdom on safe dosing, spiritual intention-setting, and how Seattle’s shifting psychedelic policy is creating space for a more open, informed, and inclusive community. Whether you're microdosing for emotional clarity or planning your first full trip, this episode offers practical tips and soulful reflection for midlife women navigating new frontiers in mental health.

🔵 Key Takeaways

-Golden Teacher is the most beginner-friendly strain due to its moderate potency, gentle effects, and manageable trip length.

-A typical beginner dose is 1–2 grams; trips often last 2–4 hours and include visuals, emotional clarity, and spiritual insight.

-GT can support microdosing goals like grounding, reflection, and emotional release—aka “happy cries.”

-Seattle’s decriminalization policy allows April to legally share her own psilocybin brand, Rae Rae, at community events.

-Set and setting are crucial: make sure your mindset is stable and your environment is safe before consuming.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/golden-teacher-mushroom-first-time-psychonauts

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

58. Psilocybin Mushroom Strains: What Women Need to Know About Varieties, Effects, and Origins

What’s in a strain? More than you might think. In this foundational episode of The High Guide, April Pride unpacks the fuzzy—and fascinating—world of psilocybin mushroom strains. From the origin of the word “strain” to the real differences between varieties like Golden Teacher and Ecuador, this conversation sets the stage for the rest of the season. You’ll learn how mushroom genetics compare to cannabis and wine, what to look for on a dispensary menu, and why the term “strain” isn’t always the most accurate—but still sticks. Perfect for beginners and returning psychonauts alike, this episode empowers curious women with the language and lens to guide their next high.

🔵 Key Takeaways

-Strain = Subtype: In both microbiology and cannabis, a “strain” refers to a genetically distinct version of a species—and psilocybin mushrooms follow suit.

-Landrace = Ancestral: Most modern mushroom and cannabis strains descend from landrace genetics originating in places like Africa, Mexico, and Central America.

-Variety vs. Strain: While “strain” is common in therapeutic and recreational use, “variety” is often used in scientific mycology. Both refer to differences in appearance, potency, and effect.

-Know Your Intentions: Some mushroom varieties are better suited for introspection, while others may support creativity or emotional release.

-Coming Soon: Each episode this season will spotlight one specific strain—its origin, use case, effects, and trip tips.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/psilocybin-mushroom-strains-explained

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

Integration work such as journaling, breathwork, meditation, and time in nature help reinforce the neuroplasticity created by ketamine. Wondermed Lead Clinician Lauren Swanson and Field Trip Health’s Seattle ketamine clinic director Dr. Bridget Carnahan both argue that integration begins the real work of psychedelic-assisted therapy and share post-treatment integration best practices.

After listening to this episode, you will have a better understanding of: 

• Ways to encourage & what impedes neuroplasticity. 
• The importance of consistency in your integration practice 
• What to expect while integrating 
• Integration brings intentionality to a psychedelic experience  

Resources

• KetaMD [LINK]
• Field Trip Health [LINK]
• The Mental Health Benefits of Spending Time wth Friends and Family [LINK] 
• 20 Simple Ways to Spend More Time with Your Dog [LINK]

WEB getsetset.com

IG @getsetset

YOUTUBE @getsetset

EMAIL [email protected]

Created & Hosted by April Pride 

Hosted on Acast. See acast.com/privacy for more information.

With a better understanding of treatable conditions and how it affects brain function, choosing between different types of ketamine-assisted therapy hinges on potency, price, and integration protocols. 

After listening to this episode, you will have a better understanding of: 

• Different types of ketamine administrations and formulations
• How modality (IV, IM. sublingual) impacts onset, potency, and overall experience
• More about ketamine nasal therapy clinics including insurance options
• Ketamine nasal spray cost as compared to other forms of administration

WEB getsetset.com

IG @getsetset

YOUTUBE @getsetset

EMAIL [email protected]

Created & Hosted by April Pride 

Hosted on Acast. See acast.com/privacy for more information.

55. How Ketamine-Assisted Therapy Rewires the Brain

What does it mean to “reset” the brain—and how long does it last? In this episode of The High Guide, host April Pride is joined by Dr. Bridget Carnahan, Kaia Roman, and Lauren Swanson to unpack the neurochemical science of ketamine-assisted therapy (KAT). You’ll learn why ketamine's fast-acting effects matter, how it interacts with neurotransmitters like glutamate and norepinephrine, and what makes the post-session “window of freedom” so potent for rewiring your mind. From its antidepressant effects to promising new insights around ADHD, KAT offers a compelling alternative to pharmaceutical routes. As always, integration is key—because those baby dendrites need direction.

🔵 Key Takeaways

-Ketamine-assisted therapy increases neuroplasticity by modulating NMDA and AMPA receptor pathways via glutamate.

-KAT interrupts cycles of anxiety and depression, offering a 3–5 day reset to rebuild healthier neural pathways.

-Many report improved focus and reduced reliance on ADHD meds post-treatment—an emerging area of research.

-Women's hormonal cycles may affect ketamine sensitivity, pointing to the need for personalized protocols.

-KAT also shows promise for chronic pain and trauma recovery, especially when paired with integrative healing practices.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/ketamine-therapy-brain-effects-explained

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset

54. Ketamine-Assisted Therapy for Depression: Real Relief or Risk?

In this episode of The High Guide, host April Pride sits down with Kaia Roman—author, podcaster, and neuroscience researcher—to explore the real-world applications of ketamine-assisted therapy for depression, anxiety, and trauma. From Kaia’s psychedelic awakening with ayahuasca to navigating divorce during lockdown, we hear how ketamine offered not just relief, but transformation. April shares her own experience with high-functioning depression and cannabis dependency—and how ketamine helped her break that loop. You’ll also hear from Wondermed clinician Lauren Swanson on what dissociation really feels like, and how trauma survivors can approach ketamine with intention and safety. This conversation is packed with science, lived experience, and straight talk about a therapy that's controversial—but promising—for women in midlife seeking deeper healing.

🔵 Key Takeaways

-Ketamine-assisted therapy offers rapid relief for depression and anxiety, even after a single session—often within hours, not weeks.

-Dissociation, often misunderstood, can provide therapeutic distance from emotional pain and open the door to neuroplasticity.

-Kaia Roman’s story reveals how ketamine helped her through divorce and suicidal ideation, acting as a mental reset during a personal crisis.

-Ketamine’s effects differ depending on trauma history—for sexual trauma survivors, therapeutic support during integration is essential.

-Clinical research shows ketamine may also support conditions like OCD and substance use disorder, though these are still off-label uses.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/ketamine-therapy-for-depression

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow on IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠youtube.com/@getsetset⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@getsetset