SHR # 2275 :: Is Adrenal Fatigue Real? :: Ari Whitten - Adrenal fatigue is cited by many "gurus" for chronic fatigue. They blame low cortisol levels, even though an unignorable body of science shows that total daily cortisol production is NOT lower in those suffering from chronic fatigue than their healthy counterparts. Many who would have you believe that cortisol is the sole reason for chronic fatigue obviously have no idea what roles cortisol plays in the human body. Here's what you need to know about cortisol's relationship to chronic fatigue and adrenal fatigue. ::