Timestamps

0:00 – Introduction

4:12 – Humans adapt, and that changes the rules

9:58 – Diet diversity, sensitivities, and n of 1

16:51 – Assess first: biomarkers that predict disease risk

18:27 – Fixing sleep, movement, diet, environment

22:47 – Caution on rapamycin, metformin, methylene blue

25:54 – FOXO3 stem-cell study and what it means

37:15 – Mindset and willpower as real enhancers

41:44 – TMG, astaxanthin, melatonin, creatine

47:09 – VO2 max priorities and performance trade-offs

48:51 – Balancing fitness with joy and purpose

53:18 – Biomarkers mediate risk more than labels

1:01:00 – 2030–2040: what is realistic

1:04:02 – Immortality probabilities and living well now

Julian Issa video podcast: https://youtu.be/vV8yMVGLG6Y?si=XiLxOx0bSSM-xT-v

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Timestamps:

00:00 Does exercise increase inflammation

03:03 Melatonin megadosing research

04:23 NOVOS vs Blueprint VS DoNotAge

07:44 Hidden things that contribute to my health

12:14 Bon Charge sponsorship

13:05 How to improve night shift work

15:40 Supplements to take before the sauna

17:15 Does caffeine age the brain

19:34 Can you make up for lost sleep

20:40 Thoughts on Urolithin A

23:14 Doing too much for longevity

27:59 How to stop waking up at 3AM

30:57 How much sodium do I consume

33:20 Do sleep supplements blunt natural sleep

37:07 Inflammation in longevity

41:23 Importance of good relationship with food

Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025

Timestamps:00:00 Intro00:14 Taurine01:19 Apigenin01:55 Resveratrol03:20 Rapamycin04:55 Metformin06:11 Calcium AKG07:30 Melatonin08:16 SIRT609:05 NAC09:43 NMN, NR, Niacinamide11:10 Niacin13:58 Glycine15:16 Spermidine16:44 Omega-3s17:40 Creatine18:48 Pterostilbene19:19 Magnesium20:16 Vitamin K220:45 Sulforaphane21:34 Curcumin22:08 Methylated B vitamins22:33 Glutathione24:08 Lithium24:55 Lutein & Zeaxanthin25:30 Vitamin C26:29 Ergothioneine27:23 Methylene blue28:46 Multivitamin29:37 Aged garlic extract30:22 Astaxanthin31:06 TMG31:50 Ginger32:15 CoQ1032:53 PQQ33:24 Chondroitin33:45 MSM32:25 Glucosamine34:54 Conclusion

100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

Chris Dancy is called 'the most connected man on Earth' because of his pioneering use of technology in everyday life and health optimization.

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Timestamps:00:00 Intro00:23 Why Chris is the most connected man on earth03:38 How Chris used technology to lose weight and get healthy08:43 How technology changes the human experience in the future10:43 Best tools 16:28 The technology Renaissance period20:43 Bon Charge sponsorship21:38 Implants24:18 Hacking time33:28 Meditation and mindfulness36:48 Does time go by faster if you’re stuck in daily routines47:38 How Chris’ perception of time has changed as he got older52:43 Will virtual reality extend perception of lifespan59:03 How to make technology better for your health

Chris Dancy website: https://www.chrisdancy.com/

Josh Witteldorf is a PhD in physics who pivoted to researching aging and investigated the evolutionary reasons for aging and human lifespan. He's written the book Cracking the Aging Code.

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Timestamps:00:00 Intro00:30 How Josh, as a physicist, got into aging research04:35 Why aging is an evolutionary program13:50 Why humans die and age20:45 Bon Charge sponsorship21:35 Why did aging evolve as an adaptation24:40 Species that are biologically immortal30:25 Shocking way group selection selects for aging and death33:55 How predator-prey relations select for aging43:15 Can humans control our own evolution48:15 A long-term human calorie restriction experiment in Biosphere 252:50 Insulin’s effects on aging 55:20 mTOR and aging57:15 Can you deprogram aging and extend lifespan01:10:00 Gene editing01:15:15 Josh’s predictions for the future

Josh Mitteldorf blog: https://scienceblog.com/joshmitteldorf/

Josh's book Cracking the Aging Code: https://amzn.to/4mFmC6m

Start rewinding your biological clock: https://www.siimland.co/course

Get my free bloodwork cheat sheet: https://www.siimland.co/bloodwork-cheat-sheet

Timestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion

100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who researches sleep, circadian rhythms, and time-restricted eating

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Timestamps:00:00 Intro01:05 Circadian clock dysfunction and hallmarks of aging10:35 How the circadian clocks affect aging and lifespan17:00 Bon Charge sponsorship17:55 Why clock dysfunction contributes to aging24:50 What causes circadian clock dysfunction30:00 NAD metabolism and clock function31:30 Calorie restriction and meal timing36:00 Night owls vs morning larks39:35 Shift work42:18 Melatonin supplementation46:00 Clock enhancing nutraceuticals49:10 Should you supplement melatonin at old age59:45 Morning cortisol circadian rhythm01:04:50 Sunlight and UV & infrared light exposure01:09:05 How to keep your circadian clock system working well during aging

Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd

Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/

Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUU

Longevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ

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Timestamps:

00:00 Intro00:22 Dr Robbins background in longevity research01:57 What is cell senescence07:52 Benefits of senescent cells early in life09:07 Does eliminating senescent cells increase lifespan14:50 How to eliminate senescent cells17:35 Most researched senolytics22:15 Can you reverse the age of senescent cells24:00 Immune system and aging26:20 Rapamycin29:20 Practical tips to reduce your senescent cell burden33:50 Are GLP-1 receptor agonists anti-aging drugs36:55 Should people take senolytics41:05 Gene therapies for senescent cells50:45 What things need to be focused on for breakthroughs in longevity research

Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Masonic Institute on the Biology of Aging and Metabolism (MIBAM) and the Medical Discovery Team on the Biology of Aging at the University of Minnesota. Paul Robbins Research lab: https://robbins.umn.edu/

Full routine to go from average to top 1% health: https://youtu.be/dHfhTQSBAfg

➡ Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Start rewinding your biological clock: https://www.siimland.co/course

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Timestamps:00:00 Intro00:20 Greg and Siim's background06:35 Our opinion on what’s the best diet12:50 What is most important: how much you eat, what you eat, when you eat18:15 Bon Charge sponsorship19:05 How important is the timing of when you eat42:30 Best diet for top 1% longevity, top 1% athletics and general wellbeing53:00 How to structure your calories, protein, carbs and fats01:07:15 Better and worse forms of protein, carbs and fats01:30:20 Low protein vs high protein for longevity02:09:25 Low carb vs plant-based diet02:10:00 Diet tribalism on social media02:33:00 Final words

Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUU

Longevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ

Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd

Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/

Physionic Instagram: https://www.instagram.com/physionic_phd/

Physionic YouTube channel: https://www.youtube.com/@PhysionicStart rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

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Timestamps:00:00 Intro01:10 Summary of our biomarker differences02:30 Fitness markers09:45 Body composition markers14:45 Inflammation and immune markers19:30 Metabolic health markers24:15 Cardiovascular markers36:30 Kidney markers43:45 Liver markers47:00 Hormone markers53:20 Experimental longevity tests56:45 PhenoAge biological age test01:01:40 RecapMy Evidence-Based Longevity Routine: https://youtu.be/4xkRcfeGDooStart rewinding your biological clock: https://www.siimland.co/course