Today's episode explores the role of inhibitory neurons & the Sonic Hedgehog (SHH) gene in shaping the Autistic phenotype, focusing on the excitation-inhibition imbalance that drives sensory hypersensitivity and cognitive challenges. Through a neuroscience lens, the episode connects these mechanisms to heightened gamma activity.

Ben Ari Episode https://youtu.be/jo-ffwF9u0Y

Parvalbumin Interneurons episode https://youtu.be/PBHVssvoQkM?si=t8WYGlcHcv7WiE-T

Visual Thinking Part 1 https://youtu.be/XqQ8jCvWzYc?si=lffUEjGHjWj4mGOM

Neurulation Part 1 https://youtu.be/gZdg9bX3Nuw?si=xvwtlz-p1hPHI8FA

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00:00 - Autistic phenotype, excitation-inhibition imbalance, sensory hypersensitivity, cognitive deficits

03:40 - Inhibitory neurons, GABA receptors, GABA-A, GABA-B, GABA-C, tonic inhibition

07:24 - Tonic firing, burst firing, phasic firing, neural oscillations, sensory processing

08:31 - Sonic Hedgehog gene, neural development, GABAergic identity, thalamic reticular nucleus (TRN)

14:48 - Parvalbumin interneurons, fast-spiking, gamma oscillations, sensory gating, dorsolateral prefrontal cortex

18:22 - Parvalbumin dysfunction, sensory hypersensitivity, visual cortex (V1), EI imbalance, brain-derived neurotrophic factor (BDNF)

22:02 - Somatostatin interneurons, feedback inhibition, dendritic modulation, sensory adaptation, hippocampus

25:43 - Vasoactive intestinal peptide (VIP) interneurons, disinhibition, pyramidal activity, attention, social processing

29:30 - Calbindin interneurons, calretinin interneurons, dendritic inhibition, sensory processing, anterior insula

33:15 - Purkinje cells, cerebellum, motor control, cognitive timing, cell loss in autism

36:00 - Evolutionary perspective, parvalbium density, neural circuit stabilization, sensory-cognitive processing

39:25 - Gamma activity, visual processing, retina, lateral geniculate nucleus, attention to detail, autistic self

39:52 Daylight Computer Company, use "autism" for $50 discount

42:13 Chroma Light Devices, use "autism" for 10% discount

45:17 Reviews & Contact Info

X: https://x.com/rps47586

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]