The most common heart disease in cats, feline hypertrophic cardiomyopathy (HCM) often progresses silently until it causes serious complications such as congestive heart failure or sudden death. While current treatments manage symptoms, new therapies targeting the underlying disease process offer promise for preclinical feline patients. In this CE episode of our VetFolio Voice podcast, we delve into feline HCM, including a review of patient characteristics, diagnosis and treatment as well as explore new, breakthrough therapies for preclinical HCM that show promise for managing this challenging disease.