In this episode of SurgOnc Today, the SSO HPB disease site working group reviews strategies for implementation of histothripsy ablation in the management of liver primary and secondary malignancies, including a discussion of the evidence supporting it and support from the IDEAL framework for the adoption of surgical innovations into clinical practice. To do so, Drs. Miral Sadaria Grandhi and Zhi Ven Fong, members of the HPB disease site working group, are joined by Drs. Hop Tran Cao, Brock Hewitt, and Jeffrey Barkun.