Alejandro Sánchez Alvarado, Ph.D., argues that real progress in understanding regeneration comes from studying whole organisms rather than cells grown under artificial conditions. Sánchez Alvarado shows how observations from intact animals reveal organizing rules that narrow laboratory systems can miss. He presents evidence that stem cells in a studied animal lack detectable junctions with neighboring cells and instead respond to signals that travel across tissues. Sánchez Alvarado links this communication to extracellular vesicles that carry RNA and to metabolic support involving creatine, highlighting how distant tissues influence repair. Using imaging and molecular analyses, he tracks how signals move through the body and how specific cell populations change state during recovery. Sánchez Alvarado concludes that broad, comparative research is essential for uncovering general principles that govern how adult tissues restore form and function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40454]

An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer’s disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]

Clinical trials turn scientific discoveries into real options for patients and volunteers, advancing care while safeguarding participants. Sheldon Morris, M.D., M.P.H., explains how independent oversight, core ethical principles, and stepwise phases evaluate safety and benefit, and clarifies participants’ rights and responsibilities. Sandip Patel, M.D., F.A.S.C.O., highlights how carefully designed studies open access to promising cell and gene-based approaches while balancing risks and benefits. Robert A.J. Signer, Ph.D., underscores why participation—including consenting to share samples and data—helps researchers understand disease and accelerate better treatments. Morris, Patel, and Signer point audiences to practical ways to locate studies through registries and national databases, discuss what costs are typically covered, and advise asking questions about study design and safety. They also caution against unproven “stem cell tourism” and emphasize informed decisions. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40438]

Marisa Korody, Ph.D., leads groundbreaking work at the San Diego Zoo Wildlife Alliance’s Beckman Center for Conservation Research, where scientists use advanced genetic and stem cell technologies to protect endangered species. Korody highlights efforts to save the critically endangered northern white rhino by developing induced pluripotent stem cells that can be transformed into egg and sperm precursors, offering a potential path to revive the species. This research is part of a broader conservation mission that includes global projects in genetics, reintroduction, and community engagement. By combining cutting-edge science with wildlife management, the San Diego Zoo Wildlife Alliance works to preserve biodiversity and ensure the survival of species threatened by habitat loss, poaching, and climate change, demonstrating the critical role of innovation in conservation. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40451]

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Scott A. Armstrong, M.D., Ph.D., of the Dana-Farber Cancer Institute, studies how certain aggressive forms of acute myeloid leukemia (AML) develop and survive. His work centers on a protein called menin, which helps leukemia cells keep cancer-promoting genes switched on. Armstrong’s team has found that blocking menin with specially designed drugs can shut down these gene programs, push leukemia cells to mature, and slow or stop the disease in lab models and patients. While some leukemias adapt by developing mutations in menin or finding other ways to survive, his research is revealing why certain genes are especially dependent on menin and how to target them more effectively. These discoveries are now shaping new treatments, drug combinations, and potential strategies for other cancers that rely on similar mechanisms. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40875]

Sean Morrison, Ph.D., from the Children’s Medical Center Research Institute at UT Southwestern, investigates how stem cells function, regenerate, and interact with their surrounding environment in the bone marrow. His research reveals how leptin receptor-positive cells—key components of the bone marrow niche—regulate hematopoietic stem cell maintenance and regeneration, influence platelet production, and respond to physiological stress like pregnancy. Morrison uncovers a reciprocal relationship between these niche cells and peripheral nerves, showing that disrupting nerve signals impairs bone marrow recovery after chemotherapy or radiation. His work also links retrotransposon activation during pregnancy to increased red blood cell production, with implications for maternal health and transplant medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40449]

Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body’s ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]