Stem Cell Channel (Audio)

April Pyle, Department of Microbiology, Immunology and Molecular Genetics at UCLA, uses multi-disciplinary approaches to study human pluripotent stem cell biology and differentiation of these cells for use in regenerative medicine. She studies both basic aspects of stem cell biology as well as more translational aspects of human pluripotent stem cell differentiation towards skeletal muscle for use in therapeutic approaches for patients with muscular dystrophy.

Series: "Women in Science" [Health and Medicine] [Science] [Education] [Professional Medical Education] [Show ID: 34442]

Since stem cells were first cultured from human embryos in 1998, the ethical considerations surrounding this technology have been widely debated, leading to establishment of limits on how this research is conducted and funded. Learn more about these scientific advances, the implications of these discoveries for human health, and consider how ethical norms can best be integrated into research and practice. Series: "Exploring Ethics" [Humanities] [Show ID: 33712]

Laurie A. Boyer, PhD, Associate Professor of Biology and Biological Engineering at MIT, discusses her work studying cell fate and cardiac regeneration. She shares how her lab is dissecting the gene regulatory mechanisms that control lineage commitment during heart development and congenital heart defects and applying this knowledge toward engineering cardiac tissues. Series: "Women in Science" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 33775]

TBR1 and AUTS2, the development of the cerebral cortex, and developmental transcription factors. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Education] [Professional Medical Education] [Show ID: 33773]

Alysson Muotri of UC San Diego's Stem Cell Program discusses his work creating cortical organoids from modern humans as well as organoids with genetic characteristics similar to Neanderthal to compare differences in neural development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 33815]

Steven A. Goldman, MD, PhD discusses cell genesis and neural regeneration in the adult brain, with a focus on the use of neural stem and progenitor cells in treating demyelinating and neurodegenerative diseases. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Education] [Professional Medical Education] [Show ID: 33428]

Exploring the use of primate stem cell systems to understand the cellular and molecular mechanisms underlying species differences in cerebral cortex development. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32970]

Just ten years ago, questions about editing genomes of the next human generation were largely hypothetical. The prospect of erasing fatal or debilitating diseases was seen as a goal worth pursuing, even as some worried about the slippery slope of using this technology to create “designer babies.” Since then, the science has progressed rapidly. We now have a variety of tools that move these possibilities from theoretical to plausible. Based on his own research, as well as knowledge of the findings of others conducting stem cell research, Evan Y. Snyder, MD, PhD, FAAP will describe some of these tools and lead a discussion addressing key questions such as: Do we want to do this at all? If we are editing human genomes, then should this be done in vitro, in utero, or after birth? Are there some things we should not do? Who decides? Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Science] [Show ID: 32989]

The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]

Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms.

By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation.

Series: "UCTV Prime" [Health and Medicine] [Show ID: 32743]