January 14, 2022

Stoke Therapeutics & Acadia Pharmaceuticals are working on SYNGAP1 #S10e43

14 minutes

Stoke Therapeutics & Acadia Pharmaceuticals are working on SYNGAP1

BIG NEWS! https://www.businesswire.com/news/home/20220110005334/en/

FIVE KEY LINKS

- Dr. Kaye’s presentation - Listen to it again and again https://investor.stoketherapeutics.com/events/event-details/40th-annual-jp-morgan-healthcare-conference

- AES 2018 Poster https://www.stoketherapeutics.com/wp-content/uploads/Stoke-Poster-Dec-1.pdf

- STOKE Patent https://patents.google.com/patent/WO2017106377A1/en

- #OneYearSooner - How we can make clinical trials happen faster https://www.syngapresearchfund.org/post/oneyearsooner

- Sign up for Ciitizen - www.Ciitizen.com/SYNGAP1

SPREAD THE WORD

Twitter.com/cureSYNGAP1/status/1480546972645793794?s=20

Linkedin.com/feed/update/urn:li:activity:6886314132866506753

Facebook.com/cureSYNGAP1/posts/946801809535615

WHO IS WHO AT STOKE

https://www.cshl.edu/research/faculty-staff/adrian-r-krainer/ PhD Harvard 1986

https://www.linkedin.com/in/huwnash/ PhD Harvard 1997, EIR ATP since 2014

https://www.oligotherapeutics.org/officers/isabel-aznarez-ph-d/ PhD Toronto 2006

https://www.linkedin.com/in/barryticho/ MD PhD Chicago

https://www.linkedin.com/in/edward-kaye-0a46a710/ MD Loyola Chicago

COMPANIES

Stoke https://www.stoketherapeutics.com/ $ACAD

Acadia https://www.acadia-pharm.com/ $STOK

OTHER GREAT LINKS

DSF on the Monarch https://www.dravetfoundation.org/wp-content/uploads/2020/04/Stoke-Community-FAQ-April-2020.pdf

It starts with Spinraza https://www.ninds.nih.gov/About-NINDS/Impact/NINDS-Contributions-Approved-Therapies/Nusinersen-Spinraza%C2%AE-%E2%80%93-Spinal-Muscular aka https://en.wikipedia.org/wiki/Nusinersen

Grant made in 2003, Phase 1 in 2011 (dec) FDA approval in 2016 (Dec) https://www.curesma.org/fda-approves-spinraza-for-sma/

From: https://www.bizjournals.com/boston/news/2018/01/04/ex-sarepta-ceo-takes-helm-of-genetic-disease.html

Kaye said he was recruited by Stoke co-founder Adrian Krainer, with whom he previously worked at Genzyme before joining Sarepta in 2010. Krainer is perhaps best known for being an inventor of another “antisense” drug targeting a genetic disease, Biogen’s spinal muscular atrophy treatment Spinraza.

“He was one of the real originators of RNA therapy,” Kaye said. “I thought (Stoke) was at a point where it needed to be shepherded from preclinical development into the clinic. It was a really exciting opportunity.”

Stoke Origins: https://endpts.com/gene-therapy-startup-stoke-therapeutics-secures-another-90m-in-series-b-funding/ $40M from ATP in 2018. https://www.appletreepartners.com/portfolio#stoke-therapeutics

IPO June 2019 $163M/ https://www.spglobal.com/marketintelligence/en/news-insights/trending/OTV6RnpzTCGYyRs_gx1m7A2

REMEMBER

Raise funds at https://syngap.fund/give

Sign up for this 10 minute #podcast #SYNGAP10 here https://syngap.fund/10 if you want a direct link for Apple: https://syngap.fund/10a

Episode 43 of #Syngap10 - January 14, 2022

#StokedAboutStoke #ASO #SYNGAP1 #AcadiaPharma #StokeTx

#F78A1 #Syngap #epilepsy #autism #intellectualdisability #id #raredisease #epilepsyawareness #autismawareness #rarediseaseresearch #SynGAPResearchFund #CareAboutRare #PatientAdvocacy #GCchat #Neurology #Genetics

...more

View all episodes

By Syngap Research Fund, 501(c)(3)

8383 ratings