As medications for tuberculosis became available, the need for the sanatorium waned. While the transition to nursing home care began in the 1950s, by 1971 it officially became a St. Louis County nursing home, known as Nopeming Nursing Home.

By 2002, the county made the decision to close the facility, ending another chapter of Nopeming's history.

Just a few years later, a new chapter began when the building was purchased by Frank Vennes Jr., a Twin Cities businessman now serving prison time for his involvement in Tom Petter's Ponzi scheme.