Will Mizzou be able to handle the step-up in competition when they face Kansas this Saturday? Bill Connelly of ESPN joined the Big Show on Wednesday to talk about what both teams have shown so far, and his reactions to the marquee games from Week 1 of college football.

Andy and Brenden give their most surprising takeaways from Week 1 of the college football season. Plus, more takes on the upcoming Mizzou/Kansas matchup, and bold NFL predictions for the 2025 season.

Can Mizzou withstand long-term injuries to Sam Horn and Blake Craig? Andy and Brenden discuss Drinkwitz's comments on the injuries and the rivalry game against Kansas. The Injury Expert Will Carroll joins to talk Cardinals and Royals injuries. Plus, Under The Bus to the Oregon Duck mishap that The Big Show might have predicted!

Will Nolan Arenado get back on the field before the Cardinals' season ends? The Injury Expert Will Carroll joined the Big Show to discuss both the Cardinals and Royals managing several injuries down the stretch of the season. Plus, Will's thoughts on Sam Horn's leg injury for Mizzou football.

Andy and Brenden debate if they saw what they needed to be convinced by this year's Tiger football squad. Plus, the guys and producers give their Picks of the Week.

Andy and Brenden discuss the Tiger's win in the season opener and the injuries some of the Tiger's sustained during the game. Plus, Rob Veno joins the show, while Jerry Jones goes Under The Bus.

Where are the best bets in week one of the college football season? Rob Veno of WagerTalk.com joined the Big Show on Friday to talk about the major matchups in non-conference play this weekend, and the shocking trade involving Micah Parsons from Thursday.

Beau Pribula's big night, two unfortunate injuries, and a dominant defensive performance... Check out Andy Humphrey's Knee-Jerk Reactions from Mizzou's first game of the 2025 season!

Andy and Brenden debate over-unders they have for both individual players and the team in the Missouri Tiger's season opener. Plus, the guys give their bold predictions for the Tigers.

Andy and Brenden discuss the Rahsee Rice suspension and what that could mean on the Chiefs' playoff hopes. Plus, Calum McAndrew from the Columbia Tribune joins the show to give his thoughts about the upcoming Tiger football season.