Dr. Drew Pinsky (Chief Patient Officer, The Wellness Company, and Podcast Host, "Ask Dr. Drew") joins Chris Cuomo for a wide-ranging conversation about what went wrong during the pandemic and how science was hijacked by politics. Drew explains why mandates lacked bioethical standing, why “irrational certitude” is so dangerous, and why “rational uncertainty” must be at the heart of science.

They also discuss long Covid and vaccine injuries, the collapse of trust in institutions, and how arrogance replaced humility in public health. Dr. Drew warns about the dangers of narcissism, scapegoating, and mob thinking, and shares why the pessimism of young people scares him the most. At the same time, he talks about what gives him hope — resilience, families, and the possibility of finding meaning in difficult times.

NOTE: This conversation was recorded before the killing of Charlie Kirk.

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On August 22, 23-year-old Iryna Zarutska, a Ukrainian refugee, was fatally stabbed on a train in Charlotte, North Carolina. The suspect, DeCarlos Brown Jr., had a long history of arrests and court appearances, repeatedly entering and exiting the justice system before this attack.

Chris Cuomo looks at what went wrong, from failures in mental health support to the pressures on judges and law enforcement. He explores how crime is covered, the systemic issues behind tragedies like this, and why understanding the full context matters more than partisan spin.

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Charlie Kirk, the 31-year-old conservative activist and founder of Turning Point USA, was murdered on a Utah college campus on September 10, 2025. Chris Cuomo reflects on the shock of this killing, its timing just one day before September 11, and the deeply divided reaction across the country. Some Americans grieve, others cheer, and still more look for revenge — a sign, Chris argues, of how far we’ve drifted from shared values.
In this episode, Chris examines what Charlie’s death reveals about our culture, the destructive power of social media, and why division and hate now dominate our political discourse. He urges viewers to confront the toxic systems fueling violence and rage, and challenges everyone to decide what they’ll do with this moment — before it escalates further.

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Max from UNFTR (publisher, UNFTR Media, and host, Unf*cking the Republic podcast and YouTube channel) joins Chris Cuomo to explain what he calls the greatest financial heist in modern history. Donald Trump and his family are quietly building a “shadow central bank” through a new stablecoin — a specialized type of cryptocurrency backed by U.S. Treasury assets. If two key bills moving through Congress become law, Trump’s company could take over powers traditionally held by the Federal Reserve, giving him the ability to profit when the economy falters.

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"President Donald Trump has sparked a political firestorm with a new Truth Social post demanding that Big Pharma release data on the COVID-19 vaccines developed under Operation Warp Speed, his signature pandemic initiative. Trump says he has seen “extraordinary” information about the vaccines and wants it made public — a move that could validate his program while putting him at odds with much of his own base, which has spent years pushing anti-vaccine narratives that fueled the MAGA misinformation machine. This surprise turn creates a rare opportunity for Democrats to challenge those narratives and highlight the truth about what the vaccines did and didn’t do, even if it indirectly boosts Trump’s legacy.

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America isn’t a direct democracy — and Chris Cuomo wants to explain why that distinction matters. In this episode, he breaks down the difference between a constitutional republic and majority rule, showing how the structure of the Senate and Electoral College give disproportionate power to smaller states. He highlights how one-third of the U.S. population controls half the Senate and explores how this imbalance shapes our politics.

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Chris Cuomo responds to a new round of listener calls and viewer comments, including allegations of Donald Trump’s ties to Jeffrey Epstein, questions about sanctions on Russia, and concerns from veterans about the state of the VA. He also addresses faith-driven messages, criticism over an AOC deepfake post, and comments on his interviews with Tucker Carlson, Benny Johnson, and Matt Taibbi. Cuomo reflects on charges of bias, the misuse of the word “woke,” and why civil dialogue matters in today’s politics. He also revisits his longstanding interest in UFO transparency, weighing in on government secrecy and the push for accountability.

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Chris Cuomo takes on Trump’s move to declare an emergency in Washington, D.C., arguing that Democrats risk losing ground when they appear to dismiss real problems like crime, affordability, and immigration simply because they oppose Trump’s solutions. Cuomo stresses that ignoring grievances only alienates the majority of voters.

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Donald Trump has declared a crime emergency in Washington, D.C., invoking federal power to take temporary control of the city’s police force. Chris Cuomo breaks down what this move really means — why it may resonate with voters who like a show of force, and why Democrats risk losing the argument if they frame it the wrong way.

Chris explores whether deploying the National Guard and military-style policing actually reduces crime, the deeper social conditions fueling violence, and how the politics of “law and order” shape public perception. Is this about safety — or strategy?

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Benny Johnson (political commentator and host, “The Benny Show”) joins Chris Cuomo for a raw and often combative conversation about politics, media, and the future of the country. From pandemic hindsight to Trump’s political legacy, Cuomo and Johnson clash over freedom, responsibility, and how America should remember its leaders.

The discussion also dives into divisiveness in politics, conspiracy theories surrounding Jeffrey Epstein, the role of the media, and whether algorithms and online platforms should enforce ethical standards. Cuomo and Johnson push back against each other, but also find moments of agreement on the need for decency, accountability, and better solutions for families and communities.

Follow and subscribe to The Chris Cuomo Project on Apple Podcasts, Spotify, and YouTube for new episodes every Tuesday and Thursday: https://linktr.ee/cuomoproject

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