In this episode of The Cognitive Revolution, Nathan explores the groundbreaking paper on obfuscated activations with 3 members from the research team - Luke Bailey, Eric Jenner, and Scott Emmons. The team discusses how their work challenges latent-based defenses in AI systems, demonstrating methods to bypass safety mechanisms while maintaining harmful behaviors. Join us for an in-depth technical conversation about AI safety, interpretability, and the ongoing challenge of creating robust defense systems.

Do check out the "Obfuscated Activations Bypass LLM Latent-Space Defenses" paper here: https://obfuscated-activations.github.io/

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

SPONSORS:

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers. OCI powers industry leaders like Vodafone and Thomson Reuters with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before March 31, 2024 at https://oracle.com/cognitive

NetSuite: Over 41,000 businesses trust NetSuite by Oracle, the #1 cloud ERP, to future-proof their operations. With a unified platform for accounting, financial management, inventory, and HR, NetSuite provides real-time insights and forecasting to help you make quick, informed decisions. Whether you're earning millions or hundreds of millions, NetSuite empowers you to tackle challenges and seize opportunities. Download the free CFO's guide to AI and machine learning at https://netsuite.com/cognitive

Shopify: Dreaming of starting your own business? Shopify makes it easier than ever. With customizable templates, shoppable social media posts, and their new AI sidekick, Shopify Magic, you can focus on creating great products while delegating the rest. Manage everything from shipping to payments in one place. Start your journey with a $1/month trial at https://shopify.com/cognitive and turn your 2025 dreams into reality.

Vanta: Vanta simplifies security and compliance for businesses of all sizes. Automate compliance across 35+ frameworks like SOC 2 and ISO 27001, streamline security workflows, and complete questionnaires up to 5x faster. Trusted by over 9,000 companies, Vanta helps you manage risk and prove security in real time. Get $1,000 off at https://vanta.com/revolution

RECOMMENDED PODCAST:

Check out Modern Relationships where Erik Torenberg interviews tech power couples and leading thinkers to explore how ambitious people actually make partnerships work. This season's guests include: Delian Asparouhov & Nadia Asparouhova, Kristen Berman & Phil Levin, Rob Henderson, and Liv Boeree & Igor Kurganov.

Apple: https://podcasts.apple.com/us/podcast/id1786227593

Spotify: https://open.spotify.com/show/5hJzs0gDg6lRT6r10mdpVg

YouTube: https://www.youtube.com/@ModernRelationshipsPod

CHAPTERS:

(00:00:00) Teaser

(00:00:46) About the Episode

(00:05:11) Latent Space Defenses

(00:08:41) Sleeper Agents

(00:15:06) Three Case Studies (Part 1)

(00:17:02) Sponsors: Oracle Cloud Infrastructure (OCI) | NetSuite

(00:19:42) Three Case Studies (Part 2)

(00:24:09) SQL Generation

(00:26:17) Understanding Defenses

(00:32:52) Out-of-Distribution Detection (Part 1)

(00:35:37) Sponsors: Shopify | Vanta

(00:38:52) Out-of-Distribution Detection (Part 2)

(00:45:13) Loss Function Weighting

(00:57:49) Who Moves Last?

(01:11:41) High-Level Triggers

(01:25:33) Open Source vs. Access

(01:38:57) Internalizing Reasoning

(01:53:07) Representing Concepts

(02:06:38) Final Thoughts

(02:09:33) Outro

Nathan explores the cutting-edge intersection of AI and rare disease research with Dr. Catherine Brownstein of Boston Children's Hospital and Harvard Medical School. In this episode of The Cognitive Revolution, we dive into how frontier AI models are revolutionizing the diagnosis of rare diseases. Join us for an insightful conversation with a ChatGPT Pro grant winner who's pioneering the use of AI to help patients find answers faster.

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

Check out Modern Relationships, where Erik Torenberg interviews tech power couples and leading thinkers to explore how ambitious people actually make partnerships work. This season's guests include: Delian Asparouhov & Nadia Asparouhova, Kristen Berman & Phil Levin, Rob Henderson, and Liv Boeree & Igor Kurganov.

Apple: https://podcasts.apple.com/us/podcast/id1786227593

Spotify: https://open.spotify.com/show/5hJzs0gDg6lRT6r10mdpVg

YouTube: https://www.youtube.com/@ModernRelationshipsPod

SPONSORS:

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers. OCI powers industry leaders like Vodafone and Thomson Reuters with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before March 31, 2024 at https://oracle.com/cognitive

NetSuite: Over 41,000 businesses trust NetSuite by Oracle, the #1 cloud ERP, to future-proof their operations. With a unified platform for accounting, financial management, inventory, and HR, NetSuite provides real-time insights and forecasting to help you make quick, informed decisions. Whether you're earning millions or hundreds of millions, NetSuite empowers you to tackle challenges and seize opportunities. Download the free CFO's guide to AI and machine learning at https://netsuite.com/cognitive

Shopify: Dreaming of starting your own business? Shopify makes it easier than ever. With customizable templates, shoppable social media posts, and their new AI sidekick, Shopify Magic, you can focus on creating great products while delegating the rest. Manage everything from shipping to payments in one place. Start your journey with a $1/month trial at https://shopify.com/cognitive and turn your 2025 dreams into reality.

Vanta: Vanta simplifies security and compliance for businesses of all sizes. Automate compliance across 35+ frameworks like SOC 2 and ISO 27001, streamline security workflows, and complete questionnaires up to 5x faster. Trusted by over 9,000 companies, Vanta helps you manage risk and prove security in real time. Get $1,000 off at https://vanta.com/revolution

CHAPTERS:

(00:00:00) Teaser

(00:00:56) About the Episode

(00:04:45) Rare Diseases Common

(00:06:48) Patient Journey

(00:12:57) Genome Sequencing

(00:19:39) Sponsors: Oracle Cloud Infrastructure (OCI) | NetSuite

(00:22:19) Diagnosis Process

(00:30:50) Data Pipelines

(00:35:51) Sponsors: Shopify | Vanta

(00:39:07) Interaction Graphs

(00:42:18) Data Accessibility

(00:43:42) AI in Pipelines

(00:45:40) LLM Impact

(00:48:40) Anomaly Detection

(00:52:07) Data Sharing

(00:58:49) Data Reform

(01:02:41) AI's Potential

(01:04:30) AI Applications

(01:06:57) Prompt Engineering

(01:14:51) Model Comparison

(01:19:16) Prompting Insights

(01:22:14) Move 37 Analogy

(01:24:34) Future Potential

(01:29:27) Future Experience

(01:32:39) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431

Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

In this second part of the special AMA episode, Nathan explores profound questions about AI's future and its impact on society. From painting a picture of AI utopia to discussing the challenges of consciousness and potential doom scenarios, Nathan shares insights on how we might adapt and thrive in an AI-transformed world. Join us for a thought-provoking conversation that delves into the practical strategies for engaging with AI, the role of safety measures, and the importance of maintaining ethical considerations as we navigate this technological revolution.

Check out http://aipodcast.ing for AI-powered podcast production services or reach out to Adithyan for more information.

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

SPONSORS:

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers. OCI powers industry leaders like Vodafone and Thomson Reuters with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before March 31, 2024 at https://oracle.com/cognitive

80,000 Hours: 80,000 Hours is dedicated to helping you find a fulfilling career that makes a difference. With nearly a decade of research, they offer in-depth material on AI risks, AI policy, and AI safety research. Explore their articles, career reviews, and a podcast featuring experts like Anthropic CEO Dario Amodei. Everything is free, including their Career Guide. Visit https://80000hours.org/cognitiverevolution to start making a meaningful impact today.

NetSuite: Over 41,000 businesses trust NetSuite by Oracle, the #1 cloud ERP, to future-proof their operations. With a unified platform for accounting, financial management, inventory, and HR, NetSuite provides real-time insights and forecasting to help you make quick, informed decisions. Whether you're earning millions or hundreds of millions, NetSuite empowers you to tackle challenges and seize opportunities. Download the free CFO's guide to AI and machine learning at https://netsuite.com/cognitive.

CHAPTERS:

(00:00:00) Teaser

(00:00:56) AI Utopia

(00:05:48) Adapting to AI

(00:08:01) Probability of Utopia

(00:10:51) Challenging Worldviews (Part 1)

(00:11:02) Sponsors: Oracle Cloud Infrastructure (OCI) | 80,000 Hours

(00:13:42) Challenging Worldviews (Part 2)

(00:23:50) Audience Questions (Part 1)

(00:24:07) Sponsors: NetSuite

(00:25:39) Audience Questions (Part 2)

(00:30:15) AI in Various Fields

(00:33:16) AI in Psychiatry

(00:36:16) Superintelligence

(00:40:50) Societal Shift with ASI

(00:49:27) Doom Discourse

(00:57:05) Existential Risk

(01:05:53) AI Takeover

(01:14:30) AI Safety Efforts

(01:18:36) Model Release Secrecy

(01:27:20) AI Consciousness

(01:37:51) Practical AI Strategies

(01:50:34) Book Recommendation

(01:59:34) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.appl...

In this special AMA episode, Nathan answers questions posed by The Cognitive Revolution podcast listeners. He discusses AI developments in 2024, including OpenAI's o3 announcement, deliberative alignment, and the future of AI technology. It is an insightful discussion about AI's impact on education, coding careers, and business sustainability in an AI-driven world.

Check out http://aipodcast.ing for AI-powered podcast production services or reach out to Adithyan for more information.

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

SPONSORS:

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers. OCI powers industry leaders like Vodafone and Thomson Reuters with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before March 31, 2024 at https://oracle.com/cognitive

80,000 Hours: 80,000 Hours is dedicated to helping you find a fulfilling career that makes a difference. With nearly a decade of research, they offer in-depth material on AI risks, AI policy, and AI safety research. Explore their articles, career reviews, and a podcast featuring experts like Anthropic CEO Dario Amodei. Everything is free, including their Career Guide. Visit https://80000hours.org/cognitiverevolution to start making a meaningful impact today.

NetSuite: Over 41,000 businesses trust NetSuite by Oracle, the #1 cloud ERP, to future-proof their operations. With a unified platform for accounting, financial management, inventory, and HR, NetSuite provides real-time insights and forecasting to help you make quick, informed decisions. Whether you're earning millions or hundreds of millions, NetSuite empowers you to tackle challenges and seize opportunities. Download the free CFO's guide to AI and machine learning at https://netsuite.com/cognitive.

CHAPTERS:

(00:00:00) Teaser

(00:01:00) AI Podcasting

(00:03:19) o3 vs. Other Models

(00:10:25) o3 Breaks Benchmarks (Part 1)

(00:14:19) Sponsors: Oracle Cloud Infrastructure (OCI) | 80,000 Hours

(00:16:59) o3 Breaks Benchmarks (Part 2)

(00:27:51) OpenAI's Safety Plan (Part 1)

(00:28:45) Sponsors: NetSuite

(00:30:18) OpenAI's Safety Plan (Part 2)

(00:39:08) Safety & Governance

(00:50:48) Tail of the Tape

(00:59:38) Underutilized Potential

(01:05:07) RAG & State Space

(01:18:14) Agentic Frameworks

(01:29:55) AI & Education

(01:35:59) Learn to Code?

(01:43:00) Defensible Moats?

(01:53:53) UBI & Wealth

(01:59:08) Contributing to AI Safety

(02:04:25) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431

Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

In this episode of The Cognitive Revolution, Nathan hosts Will Hardman, founder of AI advisory firm Veritai, for a comprehensive technical survey of vision language models (VLMs). We explore the evolution of VLMs from early vision transformers to state-of-the-art architectures like InternVL and Llama3V, examining key innovations and architectural decisions. Join us for an in-depth discussion covering multimodality in AI systems, evaluation frameworks, and practical applications with one of the field's leading experts.

Here's to the link to one of the most comprehensive reference documents for VLMs prepared by Will Hardman: https://dust-mailbox-c73.notion.site/Vision-Language-Models-11b675d75dd480af994cc474a754bb26

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

SPONSORS:

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers. OCI powers industry leaders like Vodafone and Thomson Reuters with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before March 31, 2024 at https://oracle.com/cognitive

80,000 Hours: 80,000 Hours is dedicated to helping you find a fulfilling career that makes a difference. With nearly a decade of research, they offer in-depth material on AI risks, AI policy, and AI safety research. Explore their articles, career reviews, and a podcast featuring experts like Anthropic CEO Dario Amodei. Everything is free, including their Career Guide. Visit https://80000hours.org/cognitiverevolution to start making a meaningful impact today.

CHAPTERS:

(00:00:00) Teaser

(00:00:55) About the Episode

(00:05:45) Introduction

(00:09:16) VLM Use Cases

(00:13:47) Vision Transformers (Part 1)

(00:17:48) Sponsors: Oracle Cloud Infrastructure (OCI)

(00:19:00) Vision Transformers (Part 2)

(00:24:58) OpenAI's CLIP Model

(00:33:44) DeepMind's Flamingo (Part 1)

(00:33:44) Sponsors: 80,000 Hours

(00:35:17) DeepMind's Flamingo (Part 2)

(00:48:29) Instruction Tuning with LAVA

(01:09:25) MMMU Benchmark

(01:14:42) Pre-training with QNVL

(01:32:13) InternVL Model Series

(01:52:33) Cross-Attention vs. Self-Attention

(02:14:33) Hybrid Architectures

(02:31:08) Early vs. Late Fusion

(02:34:50) VQA and DocVQA Benchmarks

(02:40:08) The Blink Benchmark

(03:05:37) Generative Pre-training

(03:15:26) Multimodal Generation

(03:37:00) Frontier Labs & Benchmarks

(03:47:45) Conclusion

(03:53:28) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431

Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

In this episode of The Cognitive Revolution, Nathan shares a fascinating cross-post from Doom Debates featuring a conversation between Liron Shapira and roon, an influential Twitter Anon from OpenAI's technical staff. They explore crucial insights into how OpenAI's team views AI's future, including discussions on AGI development, alignment challenges, and extinction risks. Join us for this thought-provoking analysis of AI safety and the mindset of those building transformative AI systems.

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

SPONSORS:

GiveWell: GiveWell has spent over 17 years researching global health and philanthropy to identify the highest-impact giving opportunities. Over 125,000 donors have contributed more than $2 billion, saving over 200,000 lives through evidence-backed recommendations. First-time donors can have their contributions matched up to $100 before year-end. Visit https://GiveWell.org, select podcast, and enter Cognitive Revolution at checkout to make a difference today.

SelectQuote: Finding the right life insurance shouldn't be another task you put off. SelectQuote compares top-rated policies to get you the best coverage at the right price. Even in our AI-driven world, protecting your family's future remains essential. Get your personalized quote at https://selectquote.com/cognitive

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers13. OCI powers industry leaders with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before December 31, 2024 at https://oracle.com/cognitive

Weights & Biases RAG++: Advanced training for building production-ready RAG applications. Learn from experts to overcome LLM challenges, evaluate systematically, and integrate advanced features. Includes free Cohere credits. Visit https://wandb.me/cr to start the RAG++ course today.

CHAPTERS:

CHAPTERS:

(00:00:00) About the Episode

(00:07:18) Introducing roon

(00:09:13) roon's Background

(00:16:40) roon the Person (Part 1)

(00:21:56) Sponsors: GiveWell | SelectQuote

(00:24:45) roon the Person (Part 2)

(00:26:43) Excitement in AI

(00:31:59) Creativity in AI

(00:40:18) Sponsors: Oracle Cloud Infrastructure (OCI) | Weights & Biases RAG++

(00:42:36) roon's P(Doom)

(00:52:25) AI Risk & Regulation

(00:53:51) AI Timelines

(01:01:20) Aligned by Default?

(01:09:16) Training vs Production

(01:14:30) Open Source AI Risk

(01:26:25) Goal-Oriented AI

(01:34:29) Pause AI?

(01:39:46) Dogecoin & Wrap Up

(01:41:06) Outro & Call to Action

(01:56:38) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.apple.com/de/podcast...

In this episode of The Cognitive Revolution, Nathan interviews Emad Mostaque, former Founder and CEO of Stability AI and Founder of The Intelligent Internet. We explore humanity's future with AI, from the stark 50-50 survival odds to Emad's optimistic vision for universal basic intelligence. Join us for a fascinating discussion about open-source AI infrastructure, the three-tier system of the Intelligent Internet, and how blockchain technology might help fund global public goods in AI development.

Check out Emad's publications on:

Emad's Twitter: https://x.com/emostaque

Emad's Blog: https://emad.posthaven.com/

Intelligent Internet Substack: https://intelligentinternet.substack.com/p/ii-intelligent-internet-primer?r=47215t&utm_campaign=post&utm_medium=web&triedRedirect=true

The Cognitive Revolution Ask Me Anything and Listener Survey: https://docs.google.com/forms/d/1aYv2XLID7RqGxj2_Y4_6x9mo_aqXcGCeLw1EQhy4IpY/edit

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

SPONSORS:

GiveWell: GiveWell has spent over 17 years researching global health and philanthropy to identify the highest-impact giving opportunities. Over 125,000 donors have contributed more than $2 billion, saving over 200,000 lives through evidence-backed recommendations. First-time donors can have their contributions matched up to $100 before year-end. Visit https://GiveWell.org, select podcast, and enter Cognitive Revolution at checkout to make a difference today.

SelectQuote: Finding the right life insurance shouldn't be another task you put off. SelectQuote compares top-rated policies to get you the best coverage at the right price. Even in our AI-driven world, protecting your family's future remains essential. Get your personalized quote at https://selectquote.com/cognitive

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers13. OCI powers industry leaders with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before December 31, 2024 at https://oracle.com/cognitive

80,000 Hours: 80,000 Hours is dedicated to helping you find a fulfilling career that makes a difference. With nearly a decade of research, they offer in-depth material on AI risks, AI policy, and AI safety research. Explore their articles, career reviews, and a podcast featuring experts like Anthropic CEO Dario Amodei. Everything is free, including their Career Guide. Visit https://80000hours.org/cognitiverevolution to start making a meaningful impact today.

CHAPTERS:

(00:00:00) Teaser

(00:00:36) About the Episode

(00:04:33) Intro

(00:09:15) AI Risk

(00:16:58) Sponsors: GiveWell | SelectQuote

(00:19:48) AI Goals

(00:23:52) AI Divergence

(00:27:50) AI & Agency

(00:32:18) Sponsors: Oracle Cloud Infrastructure (OCI) | 80,000 Hours

(00:34:57) Kids & AI

(00:39:50) Intelligent Internet

(00:48:37) Open vs. Closed AI

(00:53:30) AI Runaway

(01:01:46) Building the Future

(01:05:43) Energy & AI

(01:15:19) Hypernodes

(01:27:36) Proof of Beneficial Compute

(01:38:28) Distributed Compute

(01:45:10) Intelligent Internet Company

(01:48:37) Finding Talent

(01:55:33) Pause Letter

(01:59:50) Regulation

(02:04:04) Speed Limits

(02:06:42) Data Filtering

(02:10:54) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431

Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

In this episode of The Cognitive Revolution, Nathan explores METR's groundbreaking REBench evaluation framework with Neev Parikh. We dive deep into how this new benchmark assesses AI systems' ability to perform real machine learning research tasks, from optimizing GPU kernels to fine-tuning language models. Join us for a fascinating discussion about the current capabilities of AI models like Claude 3.5 and GPT-4, and what their performance tells us about the trajectory of artificial intelligence development.

Check out METR's work:

blog post: https://metr.org/blog/2024-11-22-evaluating-r-d-capabilities-of-llms/

paper: https://metr.org/AI_R_D_Evaluation_Report.pdf

jobs: https://hiring.metr.org/

The Cognitive Revolution Ask Me Anything and Listener Survey: https://docs.google.com/forms/d/1aYv2XLID7RqGxj2_Y4_6x9mo_aqXcGCeLw1EQhy4IpY/edit

Help shape our show by taking our quick listener survey at https://bit.ly/TurpentinePulse

SPONSORS:

GiveWell: GiveWell has spent over 17 years researching global health and philanthropy to identify the highest-impact giving opportunities. Over 125,000 donors have contributed more than $2 billion, saving over 200,000 lives through evidence-backed recommendations. First-time donors can have their contributions matched up to $100 before year-end. Visit https://GiveWell.org, select podcast, and enter Cognitive Revolution at checkout to make a difference today.

SelectQuote: Finding the right life insurance shouldn't be another task you put off. SelectQuote compares top-rated policies to get you the best coverage at the right price. Even in our AI-driven world, protecting your family's future remains essential. Get your personalized quote at https://selectquote.com/cognitive

Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers13. OCI powers industry leaders with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before December 31, 2024 at https://oracle.com/cognitive

Weights & Biases RAG++: Advanced training for building production-ready RAG applications. Learn from experts to overcome LLM challenges, evaluate systematically, and integrate advanced features. Includes free Cohere credits. Visit https://wandb.me/cr to start the RAG++ course today.

CHAPTERS:

(00:00:00) Teaser

(00:01:04) About the Episode

(00:05:14) Introducing METR

(00:07:36) Specialization of AI Risk

(00:09:52) AI R&D vs. Autonomy

(00:12:41) Benchmark Design Choices

(00:16:04) Benchmark Design Principles (Part 1)

(00:18:54) Sponsors: GiveWell | SelectQuote

(00:21:44) Benchmark Design Principles (Part 2)

(00:22:35) AI vs. Human Evaluation

(00:26:55) Optimizing Runtimes

(00:36:02) Sponsors: Oracle Cloud Infrastructure (OCI) | Weights & Biases RAG++

(00:38:20) AI Myopia

(00:43:37) Optimizing Loss

(00:47:59) Optimizing Win Rate

(00:50:24) Best of K Analysis

(01:02:26) Best of K Limitations

(01:09:04) Agent Interaction Modalities

(01:12:34) Analyzing Benchmark Results

(01:17:16) Model Performance Differences

(01:22:49) Elicitation and Scaffolding

(01:27:08) Context Window & Best of K

(01:35:17) Reward Hacking & Bad Behavior

(01:43:47) Future Directions & Hiring

(01:46:20) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Nathan discusses groundbreaking AI and biology research with Stanford Professor James Zou from the Chan Zuckerberg Initiative. In this episode of The Cognitive Revolution, we explore two remarkable papers: the virtual lab framework that created novel COVID treatments with minimal human oversight, and InterPLM's discovery of new protein motifs through mechanistic interpretability. Join us for an fascinating discussion about how AI is revolutionizing biological research and drug discovery.

Got questions about AI? Submit them for our upcoming AMA episode + take our quick listener survey to help us serve you better - https://docs.google.com/forms/d/e/1FAIpQLSefHvs1-1g5xeqM7wSirQkzTtK-1fgW_OjyHPH9DvmbVAjEzA/viewform

SPONSORS:

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CHAPTERS:

CHAPTERS:

(00:00:00) Teaser

(00:00:35) About the Episode

(00:04:30) Virtual Lab

(00:08:09) AI Designs Nanobodies

(00:14:43) Novel AI Pipeline

(00:20:31) Human-AI Interaction (Part 1)

(00:20:33) Sponsors: SelectQuote | Oracle Cloud Infrastructure (OCI)

(00:23:22) Human-AI Interaction (Part 2)

(00:32:31) Sponsors: 80,000 Hours | GiveWell

(00:35:10) Project Cost & Time

(00:41:04) Future of AI in Bio

(00:45:46) InterPLM: Intro

(00:50:30) AI Found New Concepts

(00:55:02) Discovering New Motifs

(00:57:14) Limitations & Future

(01:01:32) Outro

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Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

Nathan welcomes back computational biochemist Amelie Schreiber for a fascinating update on AI's revolutionary impact in biology. In this episode of The Cognitive Revolution, we explore recent breakthroughs including AlphaFold3, ESM3, and new diffusion models transforming protein engineering and drug discovery. Join us for an insightful discussion about how AI is reshaping our understanding of molecular biology and making complex protein engineering tasks more accessible than ever before.

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Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers13. OCI powers industry leaders with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before December 31, 2024 at https://oracle.com/cognitive

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CHAPTERS:

(00:00:00) Teaser

(00:00:46) About the Episode

(00:04:30) AI for Biology

(00:07:14) David Baker's Impact

(00:11:49) AlphaFold 3 & ESM3

(00:16:40) Protein Interaction Prediction (Part 1)

(00:16:44) Sponsors: Shopify | SelectQuote

(00:19:18) Protein Interaction Prediction (Part 2)

(00:31:12) MSAs & Embeddings (Part 1)

(00:32:32) Sponsors: Oracle Cloud Infrastructure (OCI) | Weights & Biases RAG++

(00:34:49) MSAs & Embeddings (Part 2)

(00:35:57) Beyond Structure Prediction

(00:51:13) Dynamics vs. Statics

(00:57:24) In-Painting & Use Cases

(00:59:48) Workflow & Platforms

(01:06:45) Design Process & Success Rates

(01:13:23) Ambition & Task Definition

(01:19:25) New Models: PepFlow & GeoAB

(01:28:23) Flow Matching vs. Diffusion

(01:30:42) ESM3 & Multimodality

(01:37:10) Summary & Future Directions

(01:45:34) Outro

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://www.linkedin.com/in/nathanlabenz/

Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

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