Grant Cohn and Ryan G. Hensley discuss whether Kyle Shanahan is losing the San Francisco 49ers locker room.

Grant Cohn and Ryan G. Hensley discuss what the loss to the Arizona Cardinals means for the San Francisco 49ers.

Grant Cohn and Ryan G. Hensley discuss what has happened to San Francisco 49ers wide receiver Brandon Aiyuk. Grant and Ryan also talk about why Deebo Samuel won't answer Grant's questions.

2:45 Why Deebo Samuel won't answer Grant's questions.

10:15 Why Brandon Aiyuk's production is down.

19:00 How important is the upcoming game against the Cardinals?

23:35 The 49ers' biggest concern.

29:50 Where in the world is Leonard Floyd?

32:55 The rookie who needs to play more.

Grant Cohn and Ryan G. Hensley discuss what they learned about San Francisco 49ers quarterback Brock Purdy when he was mic'd up against the New England Patriots. Grant and Ryan also break down how the 49ers match up with the Arizona Cardinals.

4:30 Injury updates.

6:50 Is Ricky Pearsall nearing a return?

10:55 How the 49ers match up with the Cardinals.

26:30 Are the 49ers good enough to win a Super Bowl this season?

34:10 What we learned about Brock Purdy when he was mic'd up.

37:50 Grant's advice for Brock Purdy.

Grant Cohn and Ryan G. Hensley discuss whether the San Francisco 49ers will trade for Las Vegas Raiders wide receiver Davante Adams. Grant and Ryan also take a close look at Brock Purdy's statistics and performance.

2:30 Can the 49ers pull off a trade for Davante Adams?

6:30 Ranking the three big contracts the 49ers gave out this offseason.

16:10 Brock Purdy's rankings.

24:10 The 49ers offensive line rankings.

31:05 Rookie UDFA DT Evan Anderson -- a pleasant surprise.

32:40 Will Ricky Pearsall return this week?

35:25 Grant's advice for Kyle Shanahan.

Grant Cohn and Ryan G. Hensley discuss what the San Francisco 49ers are saying about Christian McCaffrey's bilateral Achilles tendonitis and what life after McCaffrey could look like for the 49ers.

Grant Cohn and Ryan G. Hensley discuss whether the 30-13 win over the New England Patriots proves the San Francisco 49ers are back. Grant and Ryan also assess Brock Purdy's performance and give advice to embattled wide receiver Brandon Aiyuk.

1:15 Honest assessment of Brock Purdy.

10:45 Honest assessment of the defense.

17:50 Are the 49ers back?

25:00 Advice for Brandon Aiyuk.

Grant Cohn asks Tom Walsh what's wrong with the San Francisco 49ers, plus much more.

Grant Cohn holds an emergency San Francisco 49ers quality control meeting to help the team avoid losing its third game in a row.

Grant Cohn and Jessie Naylor discuss whether San Francisco 49ers wide receiver Brandon Aiyuk is taking too much heat, plus much more.