The College of Glycation with Dr. Paul Reynolds

In this thought-provoking episode of the College of Glycation podcast, Dr. Paul Reynolds unpacks the powerful and overlooked connection between glycation and mental health. He explores how sugar-driven molecular damage—through advanced glycation end products (AGEs)—can inflame the brain, disrupt neurotransmitters like serotonin and dopamine, and worsen conditions such as depression, anxiety, and cognitive decline. By activating the RAGE pathway and impairing insulin signaling, glycation may serve as a biochemical bridge between metabolic dysfunction and psychiatric illness.

Dr. Reynolds also highlights how diet, gut health, and lifestyle choices shape this relationship, offering practical ways to reduce glycation and protect brain function. Drawing on cutting-edge research in metabolic psychiatry, he reveals how improving insulin sensitivity, supporting gut integrity, and lowering AGE burden may hold the key to restoring emotional resilience and mental clarity.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this insightful episode of The College of Glycation, Dr. Paul Reynolds unpacks how sugar-driven molecular reactions silently erode your strength from the inside out. Glycation—the formation of advanced glycation end products (AGEs)—crosslinks muscle proteins, stiffens connective tissue, and disrupts insulin signaling, accelerating the loss of muscle mass and power known as sarcopenia.

Drawing from current metabolic and clinical research, Dr. Reynolds explains how AGEs impair muscle regeneration, blunt key growth pathways like Akt/mTOR, and fuel inflammation that blocks repair. But it’s not all decline—he outlines practical, science-based strategies to restore resilience through resistance training, nutrient timing, and antioxidant support. Whether you’re aging, active, or simply determined to stay strong, this episode reveals how managing glycation can help preserve your mobility, vitality, and metabolic health for life.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds uncovers how glycation—the sugar-driven process behind advanced glycation end products (AGEs)—silently damages the lungs. From stiffened collagen and reduced elasticity to chronic inflammation fueled by RAGE signaling, glycation plays a hidden but powerful role in conditions like COPD, asthma, pulmonary fibrosis, and even lingering post-COVID complications.

Blending research insights with practical strategies, Dr. Reynolds explores how both internal AGEs from high blood sugar and external ones from cigarette smoke or pollution converge to undermine respiratory health. Listeners will learn how diet, antioxidants, exercise, stress management, and breathing therapies can help preserve lung function, restore resilience, and slow glycation-related decline.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals how sugar’s toxic fingerprints reshape the liver and fuel a silent epidemic: non-alcoholic fatty liver disease (NAFLD) and its aggressive cousin, NASH. Glycation and its byproducts, known as AGEs, act like molecular graffiti—damaging proteins, inflaming tissues, and driving fibrosis that can progress to cirrhosis and liver failure.

Drawing on decades of research, Dr. Reynolds unpacks the biochemical chain reaction behind liver disease, from insulin resistance and de novo lipogenesis to RAGE signaling and stellate cell activation. Most importantly, he highlights evidence-based strategies—low-carb diets, intermittent fasting, exercise, and stress reduction—that can halt or even reverse early damage. Whether you’re concerned about metabolic health or simply want to protect your liver, this lecture offers practical tools and empowering science to take control.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals the overlooked but critical connection between glycation and sleep. Far from being a passive state, sleep is when the brain and body perform vital repair work, yet advanced glycation end products (AGEs) can sabotage this process. From disrupting melatonin production and circadian rhythms to worsening conditions like sleep apnea, insomnia, and restless leg syndrome, glycation quietly undermines our most restorative rhythms.

Drawing on cutting-edge research, Dr. Reynolds explains how poor sleep, insulin resistance, and glycation form a destructive cycle—and, most importantly, how diet, exercise, stress management, and sleep hygiene can help break it. If you’ve ever struggled with sleep quality or want to protect long-term health, this episode offers both the science and the practical steps you need.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals how glycation, the sugar-driven process that creates AGEs (advanced glycation end products), undermines human fertility. From sperm DNA damage and declining egg quality to impaired endometrial receptivity and placental dysfunction, glycation silently sabotages reproduction in both men and women. Linked to PCOS, endometriosis, male infertility, and gestational diabetes, this biochemical “rust” is emerging as a hidden driver of today’s fertility crisis.

Drawing on peer-reviewed studies and clinical insights, Dr. Reynolds explains how AGEs alter reproductive biology—and, most importantly, what can be done about it. Listeners will learn actionable strategies to reduce AGE burden through diet, lifestyle, and promising new therapies. Whether you’re navigating fertility challenges, pregnancy complications, or simply seeking to better understand reproductive health, this episode offers a clear, science-backed roadmap for protecting the next generation.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds explores how sugar-driven damage in the form of advanced glycation end products (AGEs) accelerates brain aging and contributes to Alzheimer’s, Parkinson’s, depression, and other mental health challenges. He breaks down the science of glycation and insulin resistance, showing how they disrupt brain function, fuel inflammation, and create what many researchers call “Type 3 Diabetes.”

Drawing from cutting-edge research and clinical insights, Dr. Reynolds highlights why standard treatments often fall short and how nutrition—particularly ketogenic therapies and low-AGE diets—can protect and even restore brain health. Packed with practical strategies and science-backed guidance, this conversation equips listeners with the tools to reduce glycation, support cognitive performance, and take control of long-term brain health.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the surprising biochemical connection between glycation and Polymyalgia Rheumatica (PMR), a painful inflammatory disorder that limits movement and quality of life. He explains how advanced glycation end-products (AGEs) can stiffen collagen, alter fascia, and transform the interstitial fluid that should keep muscles and joints moving freely—creating the perfect environment for pain and rigidity.

Drawing on recent studies, Dr. Reynolds reveals how diet, inflammation, and oxidative stress intertwine in PMR, and why reducing sugar intake may help break the cycle. He also discusses ketogenic and low-carb eating as potential tools to lower AGE burden and ease stiffness, offering practical steps for protecting connective tissue health at any age.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this eye-opening episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—unpacks the hidden connection between glycation, mitochondrial damage, and declining cellular energy. He explains how sugar-driven advanced glycation end products (AGEs) sabotage the mitochondria—the body’s energy factories—by damaging key proteins, increasing oxidative stress, and choking off ATP production. The result? Fatigue, brain fog, metabolic inflexibility, and accelerated aging.

Blending cutting-edge research with practical strategies, Dr. Reynolds reveals how to protect and restore your mitochondria through blood sugar control, targeted nutrition, and exercise that sparks mitochondrial renewal. Whether you’re aiming for sharper thinking, higher energy, or healthier aging, this episode offers the science and solutions to keep your cellular engines running strong.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation podcast, Dr. Paul Reynolds—Professor of Cell Biology and Biomedical Scientist—uncovers how a single biochemical process, glycation, can set off a chain reaction leading to metabolic syndrome. From stiffened arteries and distorted cholesterol to insulin resistance and mitochondrial damage, advanced glycation end-products (AGEs) quietly but powerfully drive the cluster of conditions that raise the risk of heart disease, stroke, and type 2 diabetes.

Drawing on decades of research, Dr. Reynolds explains how AGEs form both inside the body and on our plates, thanks to high-heat cooking, processed foods, and sugar-heavy diets. You’ll learn how these “molecular wrecking balls” fuel inflammation, oxidative stress, and hormonal imbalance—and more importantly, how to interrupt the cycle. Packed with practical tips, this episode empowers you to make small, science-backed changes in your diet, lifestyle, and cooking habits to protect your metabolic health and longevity.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)