The College of Glycation with Dr. Paul Reynolds

In this episode of the College of Glycation, Dr. Paul Reynolds, Professor of Cell Biology and Physiology, dives into the powerful yet underrecognized link between glycation and immune dysfunction. Learn how advanced glycation end products (AGEs) sabotage immune defenses by impairing macrophages, weakening antibodies, and triggering chronic inflammation through the AGE-RAGE pathway. Dr. Reynolds unpacks how these sugar-related changes contribute to aging, insulin resistance, and increased risk of infection, autoimmunity, and chronic disease.

Backed by cutting-edge research, this lecture also offers practical strategies to protect and restore immune health—through smart dietary choices, physical activity, and antioxidant support. Whether you're a clinician, researcher, or health-conscious listener, this episode arms you with the knowledge to fight back against glycation and strengthen your body’s first line of defense.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds uncovers how sugar chemistry may be quietly compromising your vision. From cataracts and macular degeneration to diabetic retinopathy and glaucoma, glycation and its toxic byproducts—advanced glycation end products (AGEs)—wreak havoc on the delicate structures of the eye. With clarity and depth, Dr. Reynolds explains how long-lived eye proteins, oxidative stress, and insulin resistance create a perfect storm for vision loss.

Drawing on recent research and clinical insights, he outlines practical strategies to slow glycation, improve metabolic health, and protect your sight through diet, antioxidants, and lifestyle change. Whether you're managing blood sugar, concerned about aging eyes, or simply want to stay ahead of chronic disease, this episode offers science-backed tools to keep your vision clear and strong.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds explores a surprising connection between sugar chemistry and your allergies. Building on previous discussions about glycation’s role in chronic disease, he dives into how advanced glycation end products (AGEs) can damage epithelial barriers, activate inflammatory pathways, and turbocharge allergic responses—from seasonal sneezing to asthma flare-ups.

Dr. Reynolds also connects the dots between insulin resistance, processed foods, and immune overactivation, revealing how metabolic dysfunction may be silently amplifying your symptoms. Backed by peer-reviewed science and practical strategies, this episode offers a fresh perspective on why your allergies may be worse than they should be—and what you can do about it.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds explores the hidden impact of glycation on bone health—revealing how sugar-driven molecular damage weakens the very foundation of our bodies. Building on previous episodes, Dr. Reynolds explains how advanced glycation end products (AGEs) stiffen collagen, disrupt bone remodeling, and accelerate the progression of osteoporosis and osteoarthritis. Aging and insulin resistance further amplify this damage, making bones more fragile and susceptible to fractures—even when density appears normal.

Drawing from cutting-edge research and real clinical insight, Dr. Reynolds breaks down the science behind progressive matrix loss, bone cell dysfunction, and the metabolic factors that erode skeletal strength over time. This episode isn’t just informative—it’s empowering. You’ll come away with practical, evidence-based strategies to lower AGE formation, improve insulin sensitivity, and preserve bone integrity for the long haul.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

Could sugar damage be silently fueling cancer? In this powerful episode of The College of Glycation, Dr. Paul Reynolds unpacks how a little-known process called glycation might be creating the perfect storm for tumors to grow and spread.

You’ll learn how high blood sugar and insulin resistance do more than affect diabetes—they can generate toxic molecules called AGEs (advanced glycation end products) that inflame tissues, damage DNA, and create a cancer-friendly environment. Dr. Reynolds breaks down the science in clear, relatable terms and offers practical tips to protect yourself through diet, lifestyle, and smarter blood sugar control.

If you're interested in preventing cancer, aging well, or just understanding what’s really happening in your body, this episode is a must-listen.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds dives into the often-overlooked link between sugar damage and gut health. Glycation—through its toxic byproducts known as AGEs—doesn’t just age your arteries or brain; it also wreaks havoc on your digestive system. Dr. Reynolds unpacks how AGEs contribute to leaky gut, microbiome imbalance, and inflammatory bowel conditions like IBD, while also fueling insulin resistance and systemic inflammation.

Backed by cutting-edge research and clear clinical insights, this episode breaks down the molecular mayhem AGEs cause in the gut and offers practical, science-backed solutions—from dietary changes and prebiotics to blood sugar control and antioxidant support. Whether you're navigating digestive issues or simply want to protect your long-term metabolic health, this episode is a must-listen.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this powerful episode of the College of Glycation podcast, Dr. Paul Reynolds takes listeners deep into the hidden world of glycation and its devastating impact on kidney health. Building on previous episodes, Dr. Reynolds explains how advanced glycation end products (AGEs) silently damage the kidneys—compromising filtration, triggering chronic inflammation, and accelerating the march toward chronic kidney disease and dialysis. With clarity and urgency, he exposes how insulin resistance and elevated blood sugar fuel this process, creating a vicious metabolic cycle that threatens millions worldwide.

Grounded in peer-reviewed science and rich historical context, this episode also explores emerging diagnostic tools like skin autofluorescence and highlights practical strategies to reduce AGE burden through diet, cooking methods, and lifestyle changes. Whether you're navigating diabetes or simply aiming to protect your long-term kidney function, this episode is a must-listen for anyone seeking to understand and interrupt the silent sabotage of glycation.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores how your everyday food choices contribute to the formation of harmful molecules called advanced glycation end products (AGEs). From grilling and frying to processed snacks and sugary drinks, modern diets are fueling inflammation, oxidative stress, and chronic disease through both endogenous and exogenous glycation pathways.

Dr. Reynolds breaks down the science behind dietary glycation in clear terms and offers practical, evidence-based strategies to reduce your AGE exposure. Whether you're aiming to slow aging, manage blood sugar, or improve overall wellness, this episode gives you the tools to make smarter choices in the kitchen and protect your long-term health.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds turns the spotlight on the destructive interplay between glycation and diabetes, revealing how advanced glycation end products (AGEs) accelerate complications like neuropathy, retinopathy, and nephropathy. He explains how elevated blood sugar levels fuel AGE formation, setting off a chain reaction of tissue damage, inflammation, and oxidative stress—especially when insulin resistance is already in play. Backed by clinical studies and decades of metabolic research, Dr. Reynolds unpacks the biochemical feedback loop that makes glycation both a cause and consequence of worsening diabetes.

Listeners will come away with a powerful understanding of why glycation is more than a side effect—it's a core driver of diabetic complications. From the AGE-RAGE signaling pathway to tools like skin autofluorescence and strategies to lower dietary AGE intake, this episode equips you with practical science to fight back. Whether you're navigating type 1 or type 2 diabetes, or seeking to prevent long-term damage, Dr. Reynolds delivers compelling, evidence-based insights to help break the cycle of sugar-driven disease.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this eye-opening episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—takes a deep dive into how advanced glycation end products (AGEs) silently sabotage your skin and connective tissues as you age. Building on the fundamentals of glycation, Dr. Reynolds explains how sugar molecules bind to collagen and elastin, locking them into stiff, unrepairable structures that lead to wrinkles, sagging, and visible signs of aging. But the damage doesn’t stop there—AGEs trigger inflammation, oxidative stress, and impair cellular repair mechanisms, making skin not only look older but function poorly, too.

Dr. Reynolds goes beyond the surface to explore how glycation reflects a deeper metabolic crisis fueled by insulin resistance. Using compelling research and clinical insights, he connects aging skin to systemic issues in blood vessels, nerves, and organs—reminding us that our skin is a mirror of internal health. From the historical roots of glycation science to modern-day tools like skin autofluorescence, this episode is packed with actionable strategies to reduce AGE burden, improve skin health, and slow the biochemical processes of aging.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)