The College of Glycation with Dr. Paul Reynolds

In this episode of The College of Glycation, Dr. Paul Reynolds explores the damaging impact of glycation and advanced glycation end products (AGEs) on cardiovascular health. He explains how these sugar-derived molecules stiffen arteries, trigger inflammation, and contribute to conditions like hypertension, atherosclerosis, stroke, and heart failure. Backed by decades of peer-reviewed research, Dr. Reynolds walks listeners through how AGEs disrupt vascular function and why insulin resistance acts as a critical accelerator of this molecular damage.

Listeners will gain a clear understanding of how glycation contributes to heart disease—even in those without diabetes—and discover practical strategies to reduce AGE burden through diet and lifestyle. Whether you're looking to protect your heart, manage blood sugar, or understand the deeper links between metabolism and chronic illness, this episode delivers evidence-based insights with clarity and urgency.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

What if the foods we eat are quietly sabotaging our brain health? In this episode of The College of Glycation, Professor Paul Reynolds takes us deep into the science of glycation and its overlooked role in cognitive decline. From Alzheimer’s and Parkinson’s to anxiety and depression, we explore how sugar-damaged proteins—known as AGEs—wreak havoc on the brain’s delicate chemistry.

You’ll hear the latest research on how high-AGE diets, insulin resistance, and inflammation converge to accelerate aging in the brain, and why conventional medications may not be enough. But it’s not all bad news—there’s promising evidence that dietary changes, including ketogenic approaches, may offer a way forward.

If you’re curious about the hidden links between metabolism and mental health, this episode connects the dots with clarity and depth—no hype, just real science and actionable insights.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds introduces listeners to the foundational science behind oxidative stress—a hidden but powerful force behind aging and chronic disease. He breaks down how reactive oxygen species (ROS), the byproducts of energy metabolism, can damage cells when left unchecked, leading to a cascade of health issues including cardiovascular disease, diabetes, Alzheimer’s, and cancer. With clarity and depth, Dr. Reynolds traces the history of oxidative stress research, explains how modern lifestyles amplify it, and outlines how glycation and high-carb diets throw fuel on the fire.

Backed by decades of human and lab-based studies, this episode also offers science-backed strategies to reduce oxidative stress—from embracing ketogenic and Mediterranean-style diets to exercising regularly, managing stress, and getting quality sleep. Whether you're new to the concept or looking to deepen your understanding of redox biology, this episode delivers essential knowledge to help you reclaim metabolic balance and protect long-term health.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

Inflammation: it’s the reason your ankle swells after a sprain and a hidden engine behind heart disease, diabetes, and Alzheimer’s. In this foundational episode of The College of Glycation, Professor Paul Reynolds walks us through the science of inflammation—what it is, how it works, and why it’s both essential and potentially destructive.

You’ll learn the difference between acute and chronic inflammation, the signaling molecules driving these responses, and how modern lifestyles—from sugar-loaded diets to constant stress—are fanning the flames. Drawing from historical insights and cutting-edge research, this episode unpacks how inflammation connects to the biggest health challenges of our time—and more importantly, what we can do about it.

Whether you’re trying to make sense of a blood test or just want to understand your body’s internal alarm system, this is your crash course in the biology of burning out—and how to cool the fire down.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of College of Glycation, Professor Paul Reynolds dives into the science of glycation—a surprisingly important process where sugar molecules bind to proteins and fats in the body, creating compounds called AGEs that can accelerate aging and disease. Starting with the basics, Reynolds unpacks how glycation happens, why it matters for your cells, and what role sugar and processed foods play in fueling the problem.

You’ll hear how a kitchen chemistry reaction from 1912 turned into a major biomedical insight, what decades of research reveal about AGEs and chronic illness, and how diet—especially carbs and fructose—can turn up the heat. From blood vessels to brain tissue, the effects of glycation are far-reaching. Whether you're curious about nutrition, health science, or just want to understand what’s going on behind the scenes when you eat that donut, this episode brings clarity to a sticky topic.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this premiere episode, Dr. Paul Reynolds introduces The College of Glycation—a podcast dedicated to exploring how sugar and glycation impact aging, health, and chronic disease. You'll learn what glycation is, why it matters, and how this overlooked biological process connects the dots between metabolism, inflammation, and long-term wellness. Whether you're a health professional or just glycation-curious, this episode sets the stage for a science-forward journey into the sticky world of sugar and the body.

Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  

Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  

Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb 

Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  

Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)