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The Deep Six
The Deep Six episodes
- Ask Me Anything: Immune Stress, Viruses, and Aging Well | The Deep Six | Episode 41
This week on The Deep Six Podcast, Dr. James Lewerenz answers some of the most common and misunderstood health questions in this Ask Me Anything episode. He breaks down why recurrent herpes outbreaks signal immune stress, how sleep, training load, diet, and arginine balance influence viral flares, and what long-term inflammation may mean for brain health. Dr. Lewerenz also addresses cytomegalovirus and its link to accelerated aging through telomere damage.
The episode explores trending topics like methylene blue, outlining potential benefits, real limitations, and why caution is warranted without strong human data. Dr. Lewerenz closes with a clear warning on heavy metals, explaining their role in cardiovascular disease, cognitive decline, and cancer risk. The takeaway is consistent and clear: test, do not guess, and focus on fundamentals that support long-term resilience and longevity.Timestamps00:00 Welcome & AMA Introduction02:02 Understanding Herpes and Immune Health08:17 Cytomegalovirus and Accelerated Aging10:39 Methylene Blue: Benefits & Cautions16:47 Heavy Metal Toxicity and HealthAbout:Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/23 min - Gut Health Starts in the Kitchen: Practical Nutrition That Works | The Deep Six | Episode 40
This week on The Deep Six, Dr. James Lewerenz sits down with Chef Nishan Andonian of Entice Catering LLC to explore the powerful connection between food, flavor, and long-term health. Chef Nishan shares how scratch cooking, fresh herbs, and thoughtful techniques can transform clean eating into something sustainable and deeply satisfying. Together, they discuss gut health, gluten sensitivity, protein intake, and why flavorful meals help prevent overeating and support metabolic health.
The conversation also tackles popular weight loss injections, with Dr. Lewerenz explaining when GLP-1 therapies can be helpful and why improper use risks muscle loss and long-term decline. From bone broth and gluten-free alternatives to simple first steps in the kitchen, this episode reinforces a core principle: real health is built through intentional nourishment, not shortcuts.Timestamps
00:00 Welcome to the Deep Six Podcast02:27 Scratch Cooking05:50 Culinary Creations and Services08:40 Personal Health Goals and Cooking12:17 Gluten-Free Cooking Techniques18:10 Herbs, Spices, and Protein Sources22:09 Staying Full and Favorite Meals26:13 Chef’s Advice for Home Cooks31:10 GLP-1 Injections and Muscle LossGuest Links:Entice Catering Website: https://entice-family-meals.square.siteAbout:Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/40 min - The Rhythm of Recovery and Performance | The Deep Six | Episode 39
On this episode of The Deep Six, Dr. James Lewerenz sits down with Nik Hughes, drummer for the rock band Bush, to explore the physical, mental, and emotional demands of life on tour. Nik shares how drumming at a high level requires intentional training, long warmups, hydration, and recovery, especially as he ages and manages past injuries. The conversation connects performance with longevity, highlighting how fitness, nutrition, sleep, and mindset support both musicians and everyday professionals. Nik also opens up about balancing touring with family life and caring for a child with type 1 diabetes. This episode reinforces how sustainable health habits, consistency, and purpose allow people to perform at their best while protecting long-term well-being.
Chapters
00:00 Introduction to Nik Hughes, Drummer for Bush05:15 Drumming Inspirations and Influences07:30 Rock Doc to Rocker: Health on Tour11:04 Balancing Family and a Musician’s Life16:19 Travel Experiences and Cultural Connections21:00 Fitness Routine and Injury Recovery29:34 Dietary Habits and On-Tour Nutrition34:08 Evolution of Musician Lifestyles39:04 Bush’s Future and Band Culture42:44 Future of Type 1 Diabetes TreatmentGuest Links:Personal Website: https://www.nikhughesdrum.com/Band Website: https://www.bushofficial.com/About:
Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/51 min - Inside the Six-Point Model: An AMA on Prevention and Longevity | The Deep Six | Episode 38
In this AMA episode of The Deep Six Podcast, Dr. James Lewerenz answers listener questions that span daily habits, emerging diagnostics, and long-term brain and heart health. He walks through his personal non-negotiables, including gratitude, movement, heat and cold exposure, and intentional community, explaining how small daily practices shape physiology over time.
Dr. Lewerenz also highlights newer biomarkers for cognitive decline, advances in genetic cancer screening, and why cardiac imaging plays a growing role in proactive care. Throughout the conversation, he reinforces the importance of viewing health through the Six Point Model and thinking beyond short-term goals. This episode emphasizes prevention, clarity, and playing the long game so listeners can protect their brains, hearts, and overall vitality for decades to come.Chapters
00:00 Introduction to the Deep Six02:56 Daily Routine and Non-Negotiables06:50 New Biomarkers and Genetic Screening12:12 Deeper Dive into Heart Health14:47 Toxins and Cognitive Decline19:27 Long Game for Lifelong HealthAbout:Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/22 min - East Meets West: Where Chinese Medicine and Modern Longevity Align | The Deep Six | Episode 37
On this episode of The Deep Six Podcast, Dr. James Lewerenz sits down with Dr. Samantha Buchanan, DACM, owner of Pointe Acupuncture & Integrative Medicine, to explore how Chinese medicine and Western functional medicine can work together in modern longevity care. Dr. Buchanan shares how a serious running injury led her from a pre-med path into acupuncture, herbs, and integrative practice, along with what comprehensive intake and pattern-based assessment look like in real life. They break down how acupuncture may support the autonomic nervous system and vagus nerve, helping with stress, sleep, chronic pain, and recovery, and why practitioner training and licensure matter when symptoms could signal something more serious. The conversation also touches on fertility and IVF support, plus the “five pillars” fundamentals, including the often-overlooked impact of social connection on long-term health.
Chapters
00:00 Introduction to Dr. Sam’s Practice04:07 Journey to Chinese Medicine08:39 Acupuncture Experience and Diagnosis14:24 Acupuncture Approaches and Specialties19:16 The Importance of Licensed Practitioners23:56 Acupuncture for Stress and Infertility33:49 Social Life and Generational Wisdom43:20 Acupuncture for Pets and Powerful ResultsGuest Links:
Point Acupuncture: https://www.pointeacupuncture.com/About:
Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/48 min - How Nitric Oxide Supports Vascular Health and Healthy Aging | The Deep Six | Episode 36
On this episode of The Deep Six, Dr. James Lewerenz sits down with Cathy Eason, MS, BCHN, FNTP, Chief Science Officer at Berkeley Life, to unpack why nitric oxide is so central to vascular health, aging, and daily performance. Cathy explains how nitric oxide works in the body, why levels decline with age, and why endothelial health must be a lifelong priority, not just a concern after symptoms show up.
They explore the difference between amino acid-based approaches like arginine and clinically studied dietary nitrates, the role of the oral microbiome and saliva in nitric oxide production, and how support can impact blood pressure, energy, recovery, cognition, sexual wellness, and more. Cathy also previews upcoming research in peri- and post-menopausal women and shares practical reasons nitric oxide support belongs in every long-term prevention strategy.Timestamps
00:00 Welcome & Guest Introduction02:16 Cathy’s Background & Nitric Oxide Importance05:41 Gratitude and Personal Insights07:04 What is Nitric Oxide?12:26 N.O. Supplementation & Benefits17:44 Arginine vs. Nitrate Pathways & Oral Health23:12 The Entero-Salivary Pathway27:34 Top Benefits of Nitric Oxide33:03 Future Research & Menopause Focus38:43 Conclusion & Call to ActionGuest Links: https://berkeleylife.com/
About:
Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/42 min - Trust, Time, and Triage: What Really Happens in the ER | The Deep Six | Episode 35
On this episode of The Deep Six Podcast, Dr. James Lewerenz welcomes emergency medicine physician Dr. Roya Caloia for a powerful conversation about the realities of life in the ER. Dr. Caloia shares how her journey shifted from public health and OB-GYN aspirations to discovering her passion for emergency medicine, where every day offers an opportunity to impact lives during their most critical moments. She explains the challenges of modern healthcare, including the decline of long-term patient–doctor relationships, increased ER demand, and the troubling rise of anxiety, depression, and other mental health issues.
Dr. Caloia also offers practical advice for patients, including the importance of bringing medication lists, being patient with wait times, and trusting the ER team’s priorities. This episode highlights both the intensity and honor of emergency medicine, blending honesty with hope.Timestamps
00:00 Welcome & ER Doctor’s Journey04:15 The ER as a ‘Dumping Ground’11:13 Healthcare System Challenges19:20 ER Stories and Realities27:06 DO Training and Philosophy32:25 Dr. Caloia’s Leadership Role34:51 Navigating the ER: A Patient’s Guide39:39 Essential ER Preparedness Tips43:06 Don’t Fear the ER46:02 Rising Mental Health Crisis50:08 Gratitude and Life’s Simple PleasuresAbout:Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/58 min - Ask Me Anything: Building Strength, Restoring Sleep, and Boosting Energy | The Deep Six | Episode 34
Dr. Lewerenz is back with his second AMA, answering listener questions that speak to common challenges many of us face. He explains why aging and autoimmunity can lead to frequent falls and fractures and offers ways to build stronger bones, protect balance, and stay active at any age.
He also shares practical strategies for better sleep, including magnesium, melatonin, grounding sheets, peptides, and the importance of consistent sleep routines. You’ll hear what’s new in the peptide world, the growing shift to oral GLP-1 medications, and why B12 injections remain a powerful tool for energy, mood, and nerve health.With real-life stories, science-based advice, and decades of experience, this AMA gives listeners clear steps to support their health and thrive, not just survive.Chapters
00:00 Welcome & Deep Six Model Overview02:29 Falls, Fractures & Autoimmunity08:10 Decades of Sleep Troubles16:30 New in the Peptide World18:39 The Importance of B12About:
Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/24 min - Structural Health Matters: How Your Spine Shapes Your Life | The Deep Six | Episode 33
On this episode of The Deep Six Podcast, Dr. James Lewerenz welcomes world-renowned neurosurgeon Dr. Daniel Fahim for an in-depth discussion on spine health, chronic pain, and the latest surgical advances. Dr. Fahim, recognized among the nation’s top neurosurgeons, shares his journey from early fascination with the brain to performing over 700 surgeries a year. He explains how minimally invasive spine techniques and disc replacements are transforming patient recovery, reducing pain, and preserving mobility compared to traditional fusions.
The conversation also highlights warning signs of spinal cord injury, the importance of timely care to prevent chronic pain, and why patient expectations play a critical role in recovery. Dr. Fahim emphasizes fitness, motion preservation, and trust between doctor and patient as keys to lasting outcomes. This episode offers both education and reassurance for anyone facing structural challenges that impact quality of life.Chapters
00:00 Introduction to Dr. Daniel Fahim
02:47 Dr. Fahim’s Background and Reputation05:38 Passion for Neurosurgery and Spine Health08:40 Transformative Cancer Cases11:24 Advances in Spine Surgery: Fusion vs. Replacement15:50 Choosing a Spine Surgeon & First Surgery19:27 International Missionary Work & Post-Surgery Recovery22:12 Warning Signs of Spinal Cord Injury27:08 Surgeon’s Fitness and Patient Expectations30:08 Personal Spine Journey and MRI Review37:53 Minimally Invasive Spine Surgery Benefits40:23 Patient Empowerment and Trust43:00 Conclusion and Contact InformationGuest Links:
Website: drdanielfahim.comAbout:
Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/47 min - Ask Me Anything: Real Answers for Building Wellness | The Deep Six | Episode 32
Dr. James Lewerenz hosts his first Q&A, tackling listener questions with clear, science-based answers. From probiotics and hormone balance to EMF safety, immune support, and emerging therapies, he explains how targeted actions can create lasting health improvements. He highlights the foundational role of gut health, why probiotics belong in most supplement plans, and how daily habits influence long-term vitality.
The conversation also addresses health myths, environmental toxins, GLP-1 medications, and strategies for lowering inflammation, boosting immunity, and protecting against chronic disease. Every answer reinforces the goal of living with quality, purpose, and strength, using personalized approaches that help people thrive at every stage of life.Chapters
00:01 – Welcome and Introduction to the First AMA03:06 – Should Everyone Take a Probiotic?09:40 – What Is the Most Important Point of the Six-Point Model?12:32 – What Are Your Thoughts on AirPods and the Brain?18:03 – What Are the Most Common Health Myths and Misconceptions?23:14 – What Common Toxins Are We Exposed to Daily Without Realizing?26:33 – Aside from Exercise, What Is One Non-Negotiable You Do Daily for Your Health?30:21 – If You Could Tell Your Younger Self One Health Tip, What Would It Be?33:13 – How Do Estrogen Levels, Detox Pathways, and Inflammation Relate to Cancer Prevention?39:26 – What Are the Best Strategies to Boost Immunity Before a Cold or Flu?44:44 – What Is the Best Approach Once Through Perimenopause? (And Andropause for Men)52:20 – Between Exercise, Diet, and Genetics, Where’s the Most Bang for the Buck?54:14 – Besides Phlebotomies, How Can You Reduce Ferritin Without Dropping Hemoglobin Too Low?57:37 – What Is the Most Effective Treatment for Exercise-Related Hip and Back Pain?1:02:15 – What Are the Pros, Cons, and Side Effects of GLP-1 Medications and How Do You Prevent Them?About:
Dr. James Lewerenz takes a multifaceted approach to impact the lives of his patients. Using functional medicine, he looks at every patient on an individual, case-by-case basis, asks lots of questions, and works diligently to find the root cause of the individual's chronic pain or illness. Dr. Lewerenz is passionate and dedicated to bringing his personal experience, knowledge, and training to enhance one’s quality of life, at any age. Be well!Longevity Health Institute
633 E South Blvd. Ste 2200Rochester Hills, MI 48307(248) 289-6643https://www.longevityhealthinstituteinc.com/1 hr 13 min
About The Deep Six
From the publisher's feed
The Deep Six Podcast is a series of discussions about health, wellness, functional medicine and the journey we all take through life. How his six point model impacts everyone at any age . Each…
episode, Dr. James Lewerenz invites doctors, scientists, therapists, free thinkers, musicians, entertainers and anyone else to have a chat about living a purposeful, impactful healthy life. Thriving not just surviving!