CRISPR-Cas9 has rapidly transformed our ability to perform targeted gene editing. While the technique has received much interest for its potential in the field of gene therapy, advances in its high-throughput use mean it can now open up a wealth of opportunities in drug discovery too.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

In this episode, we consider the symptoms and consequences of a silo culture in drug development, and look at how interdisciplinary integration should be at the heart of every pharma business model.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

The first results for the Reproducibility Project: Cancer Biology offer insights into the time and cost of conducting replication studies in preclinical cancer biology.

With this first estimate of the resources required, the Reproducibility Project: Cancer Biology lays the foundation for developing a research funding structure that may provide appropriate incentives for completing replication studies.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

Optimizing the receptor binding kinetics of new drugs can have significant benefits, ranging from improved duration of action to enhanced efficacy through the insurmountable antagonism of dynamic physiological systems. Despite this, the kinetics of new receptor ligands are rarely measured early in the drug discovery process, largely because current assays are technically difficult and relatively low-throughput.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

The human kinome comprises 518 known protein kinases and more than 20 lipid kinases. Nearly all aspects of control within a cell are modulated by reversible phosphorylation of proteins, mediated by protein kinases.

Abnormal phosphorylation is a cause or effect of many diseases including cancer and inflammatory diseases & many pharma and biotech companies continue to undertake R&D in this area believing it to be of clinical importance.

For more information on DDW, head to:

https://www.ddw-online.com

Smac mimetics are a new class of targeted drugs being developed for the treatment of solid tumours and hematologic cancers. Smac mimetics specifically induce apoptotic cancer cell death and block pro-survival signalling in cancer cells.

This episode provides an overview of the biology of Smac, an endogenous pro-apoptotic molecule, and the development of Smac mimetics as a novel therapeutic approach to treat cancer.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

This episode summarises some of the technical and regulatory challenges posed by next-generation sequencing technologies and the efforts being made to address them.

Next-Generation Sequencing is moving quickly from early research into the regulated domains of drug development, diagnostic development, and clinical decision-making.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

This episode discusses issues around artificial intelligence & Biopharma R&D IT, and outlines how AI can be a potentially transformative technology for the biopharmaceutical and healthcare industries.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

Flow cytometry is a powerful tool for cell quantitation and analysis across a wide range of clinical and research applications. Most commonly used in the fields of immunology and haematology, recent improvements in instrument automation and throughput mean that the technique is now emerging as an increasingly attractive high-throughput screening (HTS) platform in drug discovery too.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com

This episode focuses on increasing clinical success by implementing improved methodologies in early phase drug discovery. Using primary cells and 3D culture models to enhance cancer drug discovery.

For more information on Drug Discovery World, head to:

https://www.ddw-online.com