Kinases are one of the most widely-studied drug target classes, with over 20 years in the spotlight for drug discovery research. Selecting optimized assays for screening, hit validation, selectivity profiling, and lead optimization, represents key steps towards identifying candidate compounds for preclinical and clinical development.

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The current environment for early-stage drug discovery and development is fluid and the probability of success continues to be challenging.

Advancing an idea from an academic or basic research setting into a therapeutic product that benefits patients is time- and capital-intensive, sometimes inefficient and – frustratingly often – unsuccessful.

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Identifying functional molecules with the potential to be developed into new therapeutics is often the sole aim of phenotypic drug discovery. However, the approach also provides valuable opportunities to uncover previously unknown, disease-specific drug receptors that can then be exploited through target driven means.

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With the rapid generation of biological screening data and the potential for innovative selection of compounds for screening, the importance of multivendor collaborations together with improvements in automation has never been greater in terms of helping the drug discovery community as a whole.

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The hepatitis B crisis is a worldwide unmet medical need. Hepatitis B (HBV) is the cause of a silent epidemic that has resulted in a worldwide healthcare crisis. Despite the significant burden it places on communities across the globe, hepatitis had been mainly ignored as a health and clinical development priority until recently.

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In this episode we look at the history and the challenges that exist in the biology field and examine how the cloud, ‘appification’, SaaS, micro services, web tools and other new IT architectures and endeavours are helping to change informatics support.

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Inbred mice are critical tools in biomedical research and one particular strain, known as C57BL/6 (Black 6 or B6, for short), is rapidly becoming the standard model for many applications and revolutionising modern research.

Understanding the B6 mouse, its origins, characteristics and potential is required to make full and appropriate use of this model in research and drug discovery.

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Drug discovery is undergoing a transformation powered by advances that magnitude more molecules and enable smarter selection of compounds. We are on the cusp of having previously unimaginable amounts of information about each target and many more targets to prosecute.

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There is continued pressure to fill the drug pipeline and, at the same time, globalisation of personalised medicines is complex, expensive and requires a significant time commitment.

Risk, perception and regulation have limited the adoption of biologics, biosimilars and biobetters, as small molecules and synthetic drugs have been the traditional therapeutic standard. Fortunately, innovative biological therapeutic tools and technologies are now proven to be viable, highly effective, low risk and safe.

Recent advances in robot technology are going to change the breadth of applications suitable for robots and alter how we think about robotic integration.

For researchers in the drug discovery and development space, these advancements will open up many new possible ways of thinking through automation, delivering high productivity gains and ultimately reducing drug discovery costs.

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