The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures. Today, 3D cell cultures are emerging not only as a new tool in early drug discovery, but also as potential therapeutics to treat disease.

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There is no doubt that the interest and hype around blockchain or distributed ledger technology (DLT) builds daily. The explosion of articles and books recently is testament to this. But what is a blockchain and how might DLT impact drug discovery, healthcare, Pharma and R&D?

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Epigenetic factors are rapidly taking the spotlight as major players in the critical pathways that trigger the onset and progression of numerous life-threatening and debilitating genetic diseases. Technologies that harness our growing knowledge of epigenetic mechanisms look set to revolutionise approaches to medicine and healthcare across the globe.

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Nanoparticles, and liposomes in particular, are growing in popularity as drug delivery vehicles for anti-cancer agents and inflammatory disease therapies, as well as forming the basis of a new class of vaccines. In this episode we explore nanomedicines past, present and future and their role in drug discovery and development.

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In this episode, we discuss: Process chemistry/route selection; Drug metabolism: the case of cytochrome; Metalloporphyrins as chemical mimics of cytochrome P-450 systems; Diversified analogues through automated oxidation chemistry; Precision vs Personalised Medicine; Alzheimer’s Disease; Translational chemical and systems biology drug discovery; Translational chemical biology – the gap assessment; before finally concluding.

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In this episode we discuss: current drug approvals; translational chemical biology – the knowledge deficit; reverse pharmacology observational therapeutics; renaissance of plant-based natural products; expanding chemical space; hybrid molecules; flow chemistry and chemoinformatics.

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Cancer is still one of the main causes of death worldwide, yet recent strides towards more effective treatments have been made in the form of new cancer immunotherapies. By weaponising the body’s own immune defences, these drugs have shown great promise in clinical trials and are now experiencing significant commercial success.

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In this episode, 'Pharma Derisking - Approaches to Reduce Liability to Major Metabolically-Driven Causes of Drug Attrition', we explore how intelligent application of early in vitro testing, can help mitigate major drug development risks. We discuss the three main elements central to metabolic derisking as: drug-induced liver injury (DILI), drug-drug interactions (DDI) and metabolites in safety testing (MIST).

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In this episode, we explore different novel business models to solve this problem of developing new drugs, we discuss The Harrington Project, Milner Therapeutics Institute, the Tri-Institutional Therapeutics Discovery Institute, as examples of strategic arrangements, before finally concluding.

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In this episode, we explore how artificial intelligence (AI) can transform the scientific method and, in turn, the pharmaceutical industry. We discuss the barriers to drug development, the role of Artificial Intelligence (AI), and finally how embracing technology can revolutionise the drug discovery process.

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