Therapeutic antibodies are the fastest growing class of drugs, with continuous increases in the number of innovator and biosimilar drugs in development.

We discuss the rise of therapeutic antibodies in drug discovery in favour of traditional small molecules and issues around the development of these biologics, including their tracking with antiidiotypic antibodies.

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Heterocycles are key structural components of many of the anti-cancer drugs available on the market. In this episode, we look at some of the most important heterocyclic compounds currently implicated in cancer therapy, both on the market and in development, discuss the properties that make them valuable as anti-cancer drugs, and consider the benefits of including heterocycles within high-throughput screening libraries.

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Given their ability to promote long-term survival in a percentage of cancer patients, PD-1/PD-L1 checkpoint inhibitors have fast become foundational cancer therapies. But knowing which patients may respond to these drugs is challenging, in large part because good predictive biomarkers have yet to be identified and validated.

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This episode discusses how RNA interference and CRISPR/Cas9 technologies are helping to build better mouse models and push drug discovery into a new era.

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Phenotypic screening is transforming drug discovery as advances are made in development of human-based physiologically-relevant in vitro systems.

Integration of phenotypic drug discovery approaches with target-based screening can improve success rates as assays can be leveraged for the discovery of novel mechanisms and for building knowledge of disease biology.

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Already well-established in other industries, such as retail and finance, UX (User Experience) design, holds great unlocked potential for scientific software design. Because it offers a clear path to differentiating a business and reaping benefits for the discovery pipeline, the authors suggest ways to incorporate it seamlessly into life science R&D

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There are many advantages associated with culturing cells in three-dimensional (3D) versus conventional two-dimensional (2D) tissue culture.

Scaffold-free 3D culture systems that generate spheroids (and other similar multicellular aggregations) have proved useful as they offer an easy route to access 3D culture and transition into plate-based higher throughput.

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Future medicines discovery begins and ends with patients. Its scope will no longer be limited by the walls of the lab and the moats of major pharma. It will be disease-led, highly collaborative and fast. What is needed is not just new assays, technology and ideas. It is new organisations, influencers and shared working. A generation Y approach for generation Y times.

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Increasingly, oncology agents are being used in combination. However, with complications such as drug resistance and unfavourable side-effect profiles, researchers have been looking for new ways to enhance treatment effect and tolerability. New fusion technology molecules appear to offer a beneficial synergy, but will this withstand clinical investigation and what is its future potential?

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The recent approval of the first liquid biopsy test for the diagnosis of non-small cell lung cancer (NSCLC) demonstrates how biomarker-based detection tools are becoming important components of precision medicine-based drug treatment regimes.

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