This week, Jonathan is joined by Marc Hoffman, Associate Professor in Hematologic Malignancies and Cellular Therapeutics at the University of Kansas Medical Center, to discuss novel therapies for B-cell malignancies and current challenges in hemato-oncology.  

Timestamps:    

(00:00)-Introduction 

(03:24)-What is molecular biophysics? 

(07:01)-Marc’s journey into hemato-oncology 

(09:36)-Advice to young doctors 

(13:08)-Treatment advances in diffuse large B-cell lymphoma  

(19:11)-BRUIN study: pirtobrutinib for B-cell malignancies  

(26:15)-Challenges in CAR-T therapy implementation 

(31:31)-A pharmaceutical perspective  

(38:10)-Regulatory insights into clinical trials 

(40:58)-New horizons in hemato-oncology 

(44:26)-Marc’s three wishes for healthcare 

• the emerging role of the skin microbiome in acne development and the potential of prebiotics and probiotics to restore balance and health;
• the vital importance of accurate, accessible information for young patients navigating online acne advice; and
• the urgent need for patient-centred care, better communication, and increased funding to improve acne management.

In this episode, Jonathan Sackier is joined by Eric Secemsky, a world-renowned interventional cardiologist whose innovative research and clinical expertise are redefining cardiovascular care. From pioneering advancements in pulmonary embolism interventions to leading breakthrough trials on device safety and effectiveness, Secemsky shares how cutting-edge technology and collaborative research are reshaping patient care and advancing cardiovascular treatments. 

Timestamps:     

(00:00)-Introduction   

(02:13)-Working with athletes 

(05:16)-Designing clinical trials 

(10:55)-Device challenges 

(15:31)-Resistant hypertension 

(17:03)-Renal denervation 

(23:49)-The parachute trial 

(26:54)-Inaccurate autopsies 

(29:49)-Limb ischaemia 

(33:00)-Three wishes for healthcare 

In this episode of Onc Now, Jonathan welcomes Ahmad Awada, Head of the Oncology Department at Chirec Cancer Institute in Brussels and Editor in Chief of EMJ Oncology. Together they discuss groundbreaking developments in cancer care, the promise of targeted therapies, and the importance of global collaboration in oncology. 

Timestamps:     

(00:00)-Introduction 

(01:20)-Reflecting on ESMO 2024 

(07:37)-Looking ahead to ESMO 2025 

(10:04)-Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates 

(13:24)-New cytotoxics and molecular targeted therapies for solid tumours  

(16:30)-Surgery of primary tumour in de novo metastatic breast cancer 

(19:29)-Improving survival in cancer patients 

(22:47)-Managing the risk of thromboembolism  

(24:43)-Exciting advancements on the horizon  

(29:38)-Wishes for oncology  

This week, Jonathan is joined by Dr Shahram Kordasti, Associate Professor in Applied Cancer Immunopathology at King’s College London, UK. In this episode, Dr Kordasti discusses the immunobiology of Myelodysplastic syndrome and Aplastic anaemia, the role of CD4+ T cells in myeloid malignancies, and how cutting-edge computational tools are enhancing treatment strategies.  

Timestamps: 

(00:00)-Introduction 

(01:23)-Hodgkin’s lymphoma origin  

(04:21)- Immunobiology of diseases 

(08:55)-Plasticity of T cells  

(13:42)-Computational biology and multiomics for patient stratification 

(21:00)-Standardising immune monitoring 

(25:41)- Pretreatment with systemic agents 

(27:55)- Myeloproliferative neoplasms 

(31:48)-Synthetic data generation  

(36:22)-Exciting developments on the horizon  

(39:16)-Three wishes for healthcare  

In this episode, Jonathan Sackier sits down with Tom Bradshaw to explore the rapidly evolving landscape of digital health. They discuss Bradshaw’s expertise in the clinical application of AI and digital technologies, his work with the NHS and private sector firms, and the challenges of ensuring patient safety in an increasingly digital world.  

Timestamps:     

(00:00)-Introduction  

(03:33)-Journey into digital health 

(08:52)-AI in primary care 

(12:25)-Regulating AI 

(20:24)-AI guardrails 

(26:31)-Human-in-the-Loop 

(28:19)-AI in the NHS 

(33:43)-EU regulatory standards 

(37:55)-Three wishes for healthcare   

As 2024 comes to a close, join EMJ Editor, Evgenia Koutsouki as she counts down the standout moments from the past year in the final instalment of our Highlights series. This special episode revisits the top six podcasts from 2024, showcasing the groundbreaking ideas, innovations, and expert insights that shaped the healthcare landscape. From exploring the genetic mysteries of parasitic infections to pioneering biosensors for gut health, this festive wrap-up celebrates a year of exceptional conversations and transformative research.  

Timestamps:    

(00:00)-Introduction  

(00:56)-Intersection between parasitology and genetics  

(05:55)-Learning from individuals with low cholesterol  

(09:56)-Continuous glucose monitoring and insulin pumps  

(13:43)-Brain-gut behavioural therapy  

(18:47)-Biosensors to treat gut inflammatory disorders  

(21:59)-Microbiome monitoring 

(25:50)-Wrap up 

Featured Episodes: 

1. The Fate of the Cell 

1. Innovations in Vascular Medicine: From Bench to Bedside 

1. A Personalised Approach to Diabetes 

1. Gut Instincts: Bridging Psychology and Gastroenterology 

1. Agar Art and Biosensor Breakthroughs 

1. Microbe Monitoring: New Frontiers in Pathogen Surveillance 

Evgenia Koutsouki, EMJ Editor, reflects on the most memorable moments from the EMJ Podcast over the past year in this festive highlight's episode. Throughout 2024, our podcast has featured an impressive lineup of guests discussing groundbreaking topics, including advancements in breast cancer care, the evolving landscape of heart failure treatment, revolutionary approaches to prostate disease management, and much more. Join us this holiday season as we celebrate the best conversations and insights from an incredible year in healthcare! 

Timestamps: 

(00:00)-Introduction  

(01:00)-Advancing breast cancer care  

(05:52)-The hidden drivers of hunger and weight  

(12:12)-The evolving landscape of heart failure treatment  

(16:24)-Revolutionising prostate disease management  

(21:18)-Sepsis – the silent killer  

(26:46)-Individualised prostate cancer care  

(31:22)-Wrap up  

Featured Episodes: 

Advancing Breast Cancer Science and Patient Care  

Endocrinology: The Hidden Drivers of Hunger and Weight 

Heartbeats and High Achievements 

Revolutionising Radiology: Innovations and Advances in the Field 

The Silent Killer: Spotlight on Sepsis 

Breaking Barriers in Urologic Oncology 

Moderated by Sue Saville. With speakers: Susan Davis, James Simon, Tommaso Simoncini, Jean-Yves Reginster, Angelica Hirschberg. These podcasts were sponsored by Besins Healthcare.

Moderated by Sue Saville. With speakers: Susan Davis, James Simon, Tommaso Simoncini, Jean-Yves Reginster, Angelica Hirschberg. These podcasts were sponsored by Besins Healthcare.