Pleasure is not a luxury. It is a necessity for a well functioning brain. In the very first episode of The Hole Shebang Podcast, Kristen Parise sits down with Dr. Nan Wise, a cognitive neuroscientist, certified sex therapist and author of Why Good Sex Matters, to talk about what the brain actually does during sex, why pleasure matters for our overall health and what happens when we lose the ability to feel it.
Dr. Wise explains the seven core emotional circuits wired into every mammalian brain (seeking, care, play, lust, fear, rage and panic/grief) and how they shape our sexual experiences. She shares her groundbreaking fMRI research on orgasm, including the first study to map projections of the clitoris, vagina, cervix and nipple onto the brain's somatosensory cortex. One finding that will stop you: just imagining penetration lit up the brain almost identically to orgasm itself. The most important sex organ is the brain.
The conversation covers why so many people (especially women) struggle to feel safe and comfortable in their bodies, how the current generation's phone based childhood is flattening the play system and degrading the social brain, why comprehensive sex education matters and why parents play a critical role as their children's first sex educators. Dr. Wise also gets practical, walking through breathwork techniques that activate the vagal brake and shift the nervous system out of fight or flight, the concept of erotic fingerprints (recognizing that everyone has a different sexual style, from the explorer to the soulful lover to the rough and tumble lover), and why masturbation is both a pleasure practice and an essential communication tool for partnered sex.
What You'll Learn
- How the brain's seven core emotional circuits directly shape your sexual experiences and overall wellbeing
- What fMRI studies on orgasm reveal about the brain, including why imagination alone can activate the same regions as physical stimulation
- Why body based tools like breathwork are more effective than talk therapy alone for anxiety and sexual dysfunction
- The concept of erotic fingerprints and why understanding your unique sexual style changes everything in long term relationships
- Why active sexual desire naturally waxes and wanes (especially postpartum) and why responsive desire is completely valid
Episode Chapters
00:00 Introduction and How Dr. Nan Became a Sex Neuroscientist 05:33 The Seven Core Emotional Circuits and How They Shape Sex 09:39 Pleasure as a Necessity and the Rise of Anhedonia 13:48 Active vs Responsive Desire and Why Losing Libido Is Normal 16:16 Postpartum Desire and Getting Turned On by Life 22:18 Sex Education, Parenting and Talking to Kids About Bodies 27:11 The fMRI Orgasm Studies and What They Revealed 34:45 Masturbation as Self Knowledge and the Orgasm Gap 39:44 Breathwork, the Vagal Brake and Calming Your Nervous System 48:00 Erotic Fingerprints and Sexual Styles in Relationships 56:15 The Pleasure Keyboard and Exploring Beyond Penetration 58:47 Theme Song and What The Hole Shebang Means to Dr. Nan
About Dr. Nan Wise, PhD
Dr. Nan Wise is a licensed psychotherapist, cognitive neuroscientist, certified sex therapist, board certified clinical hypnotherapist and certified relationship specialist with over 30 years of clinical experience. She earned her PhD in cognitive neuroscience at Rutgers Newark, where her dissertation research on genital stimulation, imagery and orgasm in women using fMRI has garnered international attention. Her book Why Good Sex Matters: Understanding the Neuroscience of Pleasure for a Smarter, Happier, and More Purpose Filled Life explores why our culture is experiencing more anhedonia (the inability to feel pleasure) than ever and what we can do about it.
Theme Song: "Sexual Healing" by Marvin Gaye
Connect with Dr. Nan Wise
Website: askdoctornan.com Instagram: @askdoctornan Book: Why Good Sex Matters
Connect with The Hole Shebang
Website: blueberrytherapy.ca Podcast: Listen and Subscribe Instagram: @blueberrytherapypelvichealth Upcoming Event: The Pleasure Principle Conference May 30, 2025
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